Preparation of films based on reticulated fish gelatin containing garlic essential oil.

Agro-industrial co-products, such as fish gelatin, stand out for their capacity in forming biopolymeric films, being biocompatible and non-toxic; however, its hydrophilicity poses a challenge. Essential oils, rich in bioactives, attract research interest aiming to enhance the protective barrier of films and enable their application in packaging. This study produced films based on cross-linked Nile tilapia skin gelatin, incorporating garlic essential oil. Gelatin obtained through partial collagen hydrolysis from the fish skin and cross-linked with gallic acid had hydroxyproline content of 10.02 g 100 g-1 and gel strength of 287 g, which were consistent with other studies. Oil extraction used supercritical CO2 as a solvent and ethanol as a cosolvent, following a factorial experimental design, evaluating the extraction temperature (40 °C and 70 °C) and cosolvent ratio (1:1 and 1:3), with three central points. Extraction was successful, with higher yields on a dry basis at 70 °C (88.35 %), using a 1:1 cosolvent ratio. Films incorporated with oil exhibited lower water vapor permeability (WVP) than those with only cross-linked gelatin (1.59 (g m-1 s-1 Pa-1) 1011). The film with the most suitable tensile strength (19.07 MPa), elongation (120.91 %), and WVP (1.09 (g m-1 s-1 Pa-1) 1011) properties contained garlic oil extracted at the central point (55 °C and 1:2). Thermal analysis indicated increased melting temperatures in films with added oil, suggesting low thermal degradation. These results suggest that garlic oil addition can improve the properties of fish gelatin-based films, making them promising for biodegradable packaging.

Rising Prices and Lower Medicare Reimbursement Rates Create Outrage Among Clinicians.

In a recent Hot Topics article, reimbursement rates for Medicare physicians are discussed, and how it will impact their practice.

Rising Prices and Lower Medicare Reimbursement Rates Create Outrage Among Clinicians.

In a recent Hot Topics article, reimbursement rates for Medicare physicians are discussed, and how it will impact their practice.

HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization.

HJURP is overexpressed in several cancer types and strongly correlates with patient survival. However, the mechanistic basis underlying the association of HJURP with cancer aggressiveness is not well understood. HJURP promotes the loading of the histone H3 variant, CENP-A, at the centromeric chromatin, epigenetically defining the centromeres and supporting proper chromosome segregation. In addition, HJURP is associated with DNA repair but its function in this process is still scarcely explored. Here, we demonstrate that HJURP is recruited to DSBs through a mechanism requiring chromatin PARylation and promotes epigenetic alterations that favor the execution of DNA repair. Incorporation of HJURP at DSBs promotes turnover of H3K9me3 and HP1, facilitating DNA damage signaling and DSB repair. Moreover, HJURP overexpression in glioma cell lines also affected global structure of heterochromatin independently of DNA damage induction, promoting genome-wide reorganization and assisting DNA damage response. HJURP overexpression therefore extensively alters DNA damage signaling and DSB repair, and also increases radioresistance of glioma cells. Importantly, HJURP expression levels in tumors are also associated with poor response of patients to radiation. Thus, our results enlarge the understanding of HJURP involvement in DNA repair and highlight it as a promising target for the development of adjuvant therapies that sensitize tumor cells to irradiation.

Condições de trabalho e saúde mental de agentes comunitários de saúde na pandemia de COVID-19 / Working conditions and mental health of community health workers in the COVID-19 pandemic

Resumo O objetivo deste estudo foi analisar a prevalência de ansiedade e depressão associada às condições de trabalho dos agentes comunitários de saúde (ACS) no contexto da pandemia de COVID-19. Estudo transversal, realizado no norte de Minas Gerais. Foi aplicado um questionário que abordava condições sociodemográficas, domínio de tecnologias e condições de trabalho durante a pandemia, além do Inventário de Ansiedade Traço-Estado e do Patient Health Questionnare-9 (PHQ-9). Foram realizadas análises descritivas e de regressão múltipla de Poisson com variância robusta, considerando um nível de significância de 5% (p < 0,05) para o modelo final. Participaram do estudo 1.220 ACS de 36 municípios. A prevalência foi de 41,8% e 31,6% para ansiedade e depressão, respectivamente, e 22,5% para ambas as condições. O sexo feminino, idade até 40 anos, ter mais de 500 usuários cadastrados para acompanhamento e oferta inadequada de equipamentos de proteção individual estiveram associados à ansiedade e à depressão. Registrouse uma elevada prevalência de ansiedade e depressão entre ACS no período da pandemia, com destaque para as condições de trabalho entre os fatores associados.

Abstract This study examined the prevalence of anxiety and depression associated with Community Health Workers' (CHWs') working conditions in the context of the COVID-19 pandemic. This cross-sectional study was carried out in the north of Minas Gerais, Brazil by applying a questionnaire addressing sociodemographic conditions, command of technologies and working conditions during the pandemic, as well as the State-Trait Anxiety Inventory and the Patient Health Questionnare-9 (PHQ-9). Descriptive and multiple Poisson regression analyses were performed with robust variance, to a 5% level of significance (p < 0.05) for the final model. A total of 1,220 CHWs from 36 municipalities participated in the study. Prevalences were 41.8% and 31.6% for anxiety and depression, respectively, while 22.5% of the group displayed symptoms of both conditions. Being female, up to 40 years old, having more than 500 users registered for monitoring, and inadequate supply of personal protective equipment were associated with anxiety and depression among the CHWs. Prevalence of anxiety and depression was high among CHWs during the pandemic and working conditions figured prominently among the associated factors.

External control arms: COVID-19 reveals the merits of using real world evidence in real-time for clinical and public health investigations.

Randomized controlled trials are considered the 'gold standard' to reduce bias by randomizing patients to an experimental intervention, versus placebo or standard of care cohort. There are inherent challenges to enrolling a standard of care or cohorts: costs, site engagement logistics, socioeconomic variability, patient willingness, ethics of placebo interventions, cannibalizing the treatment arm population, and extending study duration. The COVID-19 pandemic has magnified aspects of constraints in trial recruitment and logistics, spurring innovative approaches to reducing trial sizes, accelerating trial accrual while preserving statistical rigor. Using data from medical records and databases allows for construction of external control arms that reduce the costs of an external control arm (ECA) randomized to standard of care. Simultaneously examining covariates of the clinical outcomes in ECAs that are being measured in the interventional arm can be particularly useful in phase 2 trials to better understand social and genetic determinants of clinical outcomes that might inform pivotal trial design. The FDA and EMA have promulgated a number of publicly available guidance documents and qualification reports that inform the use of this regulatory science tool to streamline clinical development, of phase 4 surveillance, and policy aspects of clinical outcomes research. Availability and quality of real-world data (RWD) are a prevalent impediment to the use of ECAs given such data is not collected with the rigor and deliberateness that characterizes prospective interventional control arm data. Conversely, in the case of contemporary control arms, a clinical trial outcome can be compared to a contemporary standard of care in cases where the standard of care is evolving at a fast pace, such as the use of checkpoint inhibitors in cancer care. Innovative statistical methods are an essential aspect of an ECA strategy and regulatory paths for these innovative approaches have been navigated, qualified, and in some cases published.

Application of data mining to extract knowledge about the occurrence of fistulas after palatoplasty / Aplicação de mineração de dados para extração de conhecimento sobre ocorrência de fístulas após palatoplastia

Introduction: Data mining techniques expand access to important information for the decision-making process during health care. The objective the study proposes using data mining techniques to identify variables (surgical treatment protocols, patient characteristics, post-surgical complications) associated with fistulas after primary palatoplasty in patients with unilateral transforamen incisor cleft (UTIC). Method: A data set of 222 patients with UTIC without syndromes, operated by four surgeons with Furlow's or von Langenbeck's primary palatoplasty techniques, was analyzed for this study. Two models for detecting the outcome of surgery were induced using data mining techniques (Decision Tree and Apriori). Results: Five rules were selected from a decision tree pointing to some variables as predictors of fistulas associated with primary palatoplasty: infection, cough, hypernasality, and surgeon. Analysis of the model indicates that it correctly classifies 95.9% of occurrences between the absence and presence of fistulas. The second model indicates that the absence of post-surgical complications (infection and fever) and normal speech results (absent hypernasality, without suggestive of velopharyngeal dysfunction) are related to the absence of fistulas. Regarding surgical procedures, the Furlow technique and the Vomer flap were more frequent in patients with fistulas. Conclusion: Data mining techniques, as applied in the present study, pointed to infection and cough, hypernasality, and surgeon and surgical techniques as predictors of fistulas related to primary palatoplasty.

Introdução: As técnicas de mineração de dados ampliam o acesso a informações importantes para o processo de tomada de decisão durante os cuidados com a saúde. O objetivo do estudo propõe a utilização de técnicas de mineração de dados para identificar variáveis (protocolos de tratamento cirúrgico, características do paciente, intercorrências pós-cirúrgicas) associadas à ocorrência de fístulas após palatoplastia primária em pacientes com fissura transforame incisivo unilateral (FTIU). Método: Um conjunto de dados de 222 pacientes com FTIU sem síndromes, operados por quatro cirurgiões com as técnicas de palatoplastia primária de Furlow ou von Langenbeck, foi analisado para este estudo. Dois modelos para detecção do resultado da cirurgia foram induzidos usando técnicas de mineração de dados (Árvore de Decisão e Apriori). Resultados: Cinco regras foram selecionadas de uma árvore de decisão apontando para algumas variáveis como preditivas de fístulas associadas à palatoplastia primária: infecção, tosse, hipernasalidade, cirurgião. A análise do modelo indica que ele classifica corretamente 95,9% das ocorrências entre ausência e presença de fístulas. O segundo modelo indica que a ausência de intercorrências pós-cirúrgicas (infecção e febre) e resultado de fala normal (hipernasalidade ausente, sem sugestivo de disfunção velofaríngea) estão relacionados à ausência de fístulas. Em relação aos procedimentos cirúrgicos, o uso da técnica de Furlow e retalho de Vomer foram mais frequentes nos pacientes com fístulas. Conclusão: Técnicas de mineração de dados, conforme aplicadas no presente estudo, apontaram para infecção e tosse, presença de hipernasalidade, cirurgião e técnica cirúrgica como preditores de fístulas relacionadas à palatoplastia primária.

Functional crosstalk between the TIM22 complex and YME1 machinery maintains mitochondrial proteostasis and integrity.

TIM22 pathway cargos are essential for sustaining mitochondrial homeostasis as an excess of these proteins leads to proteostatic stress and cell death. Yme1 is an inner membrane metalloprotease that regulates protein quality control with chaperone-like and proteolytic activities. Although the mitochondrial translocase and protease machinery are critical for organelle health, their functional association remains unexplored. The present study unravels a novel genetic connection between the TIM22 complex and YME1 machinery in Saccharomyces cerevisiae that is required for maintaining mitochondrial health. Our genetic analyses indicate that impairment in the TIM22 complex rescues the respiratory growth defects of cells without Yme1. Furthermore, Yme1 is essential for the stability of the TIM22 complex and regulates the proteostasis of TIM22 pathway substrates. Moreover, impairment in the TIM22 complex suppressed the mitochondrial structural and functional defects of Yme1-devoid cells. In summary, excessive levels of TIM22 pathway substrates could be one of the reasons for respiratory growth defects of cells lacking Yme1, and compromising the TIM22 complex can compensate for the imbalance in mitochondrial proteostasis caused by the loss of Yme1.

Chitosan-based nanocapsules by emulsification containing PUFA concentrates from tuna oil.

Chitosan nanocapsules containing polyunsaturated fatty acid (PUFA) concentrates from tuna oil, with EPA + DHA contents around 57% (w w-1), were developed by emulsification process, using different chitosan concentration (1.0%, 1.5%, 2.0%, w v-1) and stirring speed (10,000, 15,000, 20,000 rpm). The effects of these parameters on particle size and zeta potential were evaluated. The physical and oxidative stabilities were used to measure the product quality during storage. Chitosan concentration, stirring speed and its interaction significantly affected (p < 0.05) the particle size. In addition, chitosan concentration significantly affected (p < 0.05) the zeta potential of nanocapsules emulsion. Based on the results of physical and oxidative stabilities, the nanocapsules were stable for 30 days under refrigeration temperature (7 °C), and with 1.5-2% chitosan resulted in improved protection against oil oxidation. The nanocapsules produced with 2% chitosan and 10,000 rpm showed the lowest variations of polydispersity index and nanocapsules size after 30 days of storage (221.8 ± 3.0 nm). These conditions can be considered the most suitable to produce nanocapsules of PUFA concentrates from tuna oil using chitosan as wall material. These nanocapsules showed physical characteristics and oxidative stability, which could enable their application in the food industry, representing an important source of EPA and DHA fatty acids.

The frequency of non-motor symptoms in SCA3 and their association with disease severity and lifestyle factors.

BACKGROUND: Non-motor symptoms (NMS) are a substantial burden for patients with SCA3. There are limited data on their frequency, and their relation with disease severity and activities of daily living is not clear. In addition, lifestyle may either influence or be affected by the occurrence of NMS. OBJECTIVE: To characterize NMS in SCA3 and investigate possible associations with disease severity and lifestyle factors. METHODS: In a prospective cohort study, we performed a cross-sectional analysis of NMS in 227 SCA3 patients, 42 pre-ataxic mutation carriers, and 112 controls and tested for associations with SARA score, activities of daily living, and the lifestyle factors alcohol consumption, smoking and physical activity. RESULTS: Sleep disturbance, restless legs syndrome, mild cognitive impairment, depression, bladder dysfunction and pallhypesthesia were frequent among SCA3 patients, while mainly absent in pre-ataxic mutation carriers. Except for restless legs syndrome, NMS correlated significantly with disease severity and activities of daily living. Alcohol abstinence was associated with bladder dysfunction. Patients with higher physical activity showed less cognitive impairment and fewer depressive symptoms, but these differences were not significant. CONCLUSION: This study revealed a clear association between disease severity and NMS, likely driven by the progression of the widespread neurodegenerative process. Associations between lifestyle and NMS can probably be attributed to the influence of NMS on lifestyle.

Perfil mercadológico digital de empreendimentos de profissionais de enfermagem divulgados via Instagram / Digital marketing profile of nursing professional ventures published via Instagram / Perfil de marketing digital de emprendimientos de profesionales de enfermería divulgados a través de Instagram

Objetivo: identificar o perfil mercadológico digital de empreendimentos de profissionais de enfermagem divulgados via Instagram. Método: estudo netnográfico, realizado no Instagram, sendo esta uma rede social de acesso público. A amostra foi composta por 15 perfis de empreendedores digitais, sendo estes profissionais de enfermagem. A coleta de dados foi realizada entre os meses de março e maio de 2022 por meio de hashtags como estratégia de busca. Resultados: houve prevalência de livros digitais (30,0%), seguido de cursos online (26,6%). As áreas empreendidas e os conteúdos produzidos foram sobre cicatrização de feridas e curativos; capacitações gerais do campo da enfermagem; direito na enfermagem; empreendedorismo para enfermeiros; furo de orelha; atendimento obstétrico; atendimentos gerais de enfermagem; e preparatório para concurso. Conclusão: houve um aumento considerável de produtos divulgados via Instagram por profissionais da enfermagem repercutindo em uma maior visibilidade, autonomia e independência da categoria profissional

Objectives: to identify the digital marketing profile of nursing professionals' ventures disclosed via Instagram. Method: netnographic study, conducted on Instagram, which is a social network of public access. The sample was composed of 15 profiles of digital entrepreneurs, which were nursing professionals. Data collection was performed between March and May 2022 using hashtags as a search strategy. Results: there was a prevalence of digital books (30,0%), followed by online courses (26,6%). The areas undertaken and the content produced were about wound healing and dressings; general training in the nursing field; law in nursing; entrepreneurship for nurses; ear piercing; obstetric care; general nursing care; and exam preparation. Conclusion: there was a considerable increase in products disseminated via Instagram by nursing professionals, resulting in greater visibility, autonomy, and independence of the professional category

Objetivos: identificar el perfil mercadológico digital de los negocios de profesionales de enfermería divulgados a través de Instagram. Método: estudio netnográfico, realizado en el instagram, siendo esta una red social pública. Muestra compuesta por 15 perfiles de empresarios digitales, siendo estos profesionales de enfermería. La recopilación de datos se realizó entre marzo y mayo de 2022 por medio de hashtags. Resultados: predominan los libros digitales (30,0%), seguidos de los cursos en línea (26,6%). Las áreas emprendidas y los contenidos elaborados fueron sobre curación de heridas y vendajes; formación general en el ámbito de la enfermería; derecho en la enfermería; espíritu empresarial para enfermeras; perforación de orejas; cuidados obstétricos; cuidados generales de enfermería; y preparación de exámenes. Conclusión: se ha producido un aumento considerable de los productos difundidos a través de Instagram por profesionales de enfermería, lo que se traduce en una mayor visibilidad, autonomía e independencia de la categoría profesional

Incidence trend of five main causes of cancer, in greater Cuiabá, Mato Grosso, Brazil, 2000 to 2016.

OBJECTIVE: To analyze the incidence trend of the five main causes of cancer, according to sex and age, in Greater Cuiabá, in the state of Mato Grosso, from 2000 to 2016. METHODS: Incidence information was obtained from the Population-Based Cancer Registry, referring to the municipalities Cuiabá and Várzea Grande (RCBP - Cuiabá). Crude incidence rates were calculated and the five main types of cancer were selected: for males, prostate (C61), lung (C33-34), colorectal (C18-21), stomach (C16) and oral cavity cancer (C00-10); and for females, breast (C50), cervix (C53), colorectal (C18-21), lung (C33-34) and thyroid gland cancer (C73). Age-adjusted rates were calculated by the direct method, using the world population as reference. Trends were estimated using the Joinpoint method and evaluated by Annual Percent Change (APC) and Average Annual Percent Change (AAPC). The Joinpoint Regression Program software, version 8.3.6.1, was used. RESULTS: During the period, there was a decreasing trend of lung (AAPC=-2.2; 95%CI -4.0--0.3) and stomach cancer (AAPC=-5.2; 95%CI -7.7--2.6) in men, and of cervix cancer (AAPC=-7.2; 95%CI -9.0--5.3) in women, and increasing for breast (AAPC=2.8; 95%CI 0.2-5.5) and thyroid cancer (AAPC=8.3; 95%CI 4.6-12.2). CONCLUSION: In Greater Cuiabá, we found a downward incidence trend among elderly men for prostate, lung and stomach cancer. Women are affected at younger age groups, with an upward trend for breast cancer and downward trend for cervix cancer.

Stomach cancer incidence and mortality in Greater Cuiabá, Mato Grosso, Brazil, 2000-2016.

OBJECTIVE: To analyze the incidence and mortality trend of stomach cancer in the Greater Cuiabá, in the state of Mato Grosso, Brazil, from 2000 to 2016. METHODS: The incidence information was obtained from the Population-Based Cancer Registry, and the mortality information from the Mortality Information System. Crude and standardized rates were calculated using the direct method, with the world population as reference. The trends were estimated using the Joinpoint regression method, according to sex and age group, and evaluated through the Annual Percent Change (APC) and the Average Annual Percent Change (AAPC). The Joinpoint Regression Program software, version 4.9.0.0, was used. RESULTS: There was a decreasing incidence trend of stomach cancer in males (AAPC=-5.2; 95% confidence interval - 95%CI -7.7--2.6), in men aged 60 to 69 years (AAPC=-3.7; 95%CI -5.6--1.8) and in 70-79 years (AAPC=-3.7; 95%CI -5.6--1.8), as well as in women aged 50 to 59 years (AAPC=-5.2; 95%CI -7.8--2.6) and 80 years or older (AAPC=-5.2; 95%IC -7.8--2.6). The mortality initially increased in women aged 60-69 years (AAPC=28.4; 95%CI 9.7-50.4), decreased for 80 years or older (AAPC=-26.4; 95%CI -38.0--12.6) and stable for the other age groups and males. CONCLUSION: A decreasing incidence trend of stomach cancer was found among men and, when analyzed by age, among elderly males and adults and elderly females, as well as a stability in the mortality, with an initial variation in elderly women. The production of regional information supports the planning of local policies aimed at reducing the burden of disease and deaths, considering unequal risk conditions and access to health services.

An Idealized Clinicogenomic Registry to Engage Underrepresented Populations Using Innovative Technology.

Current best practices in tumor registries provide a glimpse into a limited time frame over the natural history of disease, usually a narrow window around diagnosis and biopsy. This creates challenges meeting public health and healthcare reimbursement policies that increasingly require robust documentation of long-term clinical trajectories, quality of life, and health economics outcomes. These challenges are amplified for underrepresented minority (URM) and other disadvantaged populations, who tend to view the institution of clinical research with skepticism. Participation gaps leave such populations underrepresented in clinical research and, importantly, in policy decisions about treatment choices and reimbursement, thus further augmenting health, social, and economic disparities. Cloud computing, mobile computing, digital ledgers, tokenization, and artificial intelligence technologies are powerful tools that promise to enhance longitudinal patient engagement across the natural history of disease. These tools also promise to enhance engagement by giving participants agency over their data and addressing a major impediment to research participation. This will only occur if these tools are available for use with all patients. Distributed ledger technologies (specifically blockchain) converge these tools and offer a significant element of trust that can be used to engage URM populations more substantively in clinical research. This is a crucial step toward linking composite cohorts for training and optimization of the artificial intelligence tools for enhancing public health in the future. The parameters of an idealized clinical genomic registry are presented.

Prevalência de pacientes notificados com hanseníase no município de São Luís, Maranhão, durante 2010-2020 / Prevalencia de pacientes notificados con lepra en el municipio de São Luís, Maranhão, durante 2010-2020 / Prevalence of leprosy patients notified in the municipality of São Luís, Maranhão, from 2010 to 2020

Objetivo: identificar a prevalência de pacientes notificados com hanseníase em São Luís, Maranhão, durante 2010-2020. Método: estudo descritivo, exploratório, retrospectivo, transversal, quantitativo, realizado no Banco de Dados público do DATASUS cuja coleta ocorreu em agosto de 2021. A amostra foi composta por 9.387 pacientes notificados com Hanseníase. Resultados: observa-se prevalência amostral em maio de 2012, sexo masculino, faixa etária entre 30-39 anos, Ensino Médio completo, pardos, casos multibacilares, avaliação de incapacidade física e de cura no estágio Grau 0, apresentaram mais que cinco lesões, baciloscopia negativa, episódios sem reação,sendo abordados como casos novos cuja forma prevalente foi a dimorfa, tendo como esquema terapêutico mais prescrito a poliquimioterapia durante 12 meses e prevalência de cura. Conclusão: houve uma prevalência dos casos de hanseníase em homens jovens com bom grau de instrução escolar. Apesar da alta prevalência de casos novos, o tratamento foi efetivo de modo a levá-los à cura.(AU)

Objective: to identify the prevalence of patients notified with leprosy in São Luís, Maranhão, during 2010-2020. Method: descriptive, exploratory, retrospective, cross-sectional, quantitative study, conducted in the public database of the DATASUS whose collection occurred in August 2021. The sample was composed of 9,387 patients notified with Leprosy. Results: sample prevalence was observed in May 2012, male gender, age range 30-39 years, complete High School, brown, multibacillary cases, evaluation of physical disability and cure in Grade 0 stage, presented more than five lesions, negative bacilloscopy, episodes without reaction, being addressed as new cases whose prevalent form was the dimorphic, having as the most prescribed therapeutic scheme the polychemotherapy for 12 months and prevalence of cure. Conclusion: there was a prevalence of leprosy cases in young men with good schooling. Despite the high prevalence of new cases, the treatment was effective in order to lead them to cure(AU)

Objetivo: identificar la prevalencia de pacientes con lepra notificados en São Luís, Maranhão, durante 2010-2020. Método: estudio descriptivo, exploratorio, retrospectivo, transversal, cuantitativo, realizado en la base de datos pública DATASUS, la cual fue recolectada en agosto de 2021. La muestra estuvo conformada por 9.387 pacientes reportados con lepra. Resultados: se tiene una muestra de prevalencia en mayo de 2012, sexo masculino, grupo etario entre 30-39 años, bachillerato completo, pardos, casos multibacilares, valoración de incapacidad física y curación en la etapa Grado 0, presentaba más de cinco lesiones, baciloscopía negativa , episodios sin reacción, siendo abordados como casos nuevos cuya forma prevalente fue borderline, siendo el régimen terapéutico más prescrito la polimedicación durante 12 meses y prevalencia de cura.Conclusión: había una prevalencia de casos de lepra en hombres jóvenes con buena escolaridad. A pesar de la alta prevalencia de casos nuevos, el trataminto fue eficaz de manera que los curará(AU)

Fatores relacionados ao consumo alimentar saudável e não saudável entre adolescentes escolares / Factores relacionados con el consumo de alimentos saludables y no saludables entre los adolescentes escolarizados / Factors related to healthy and unhealthy food consumption among school adolescents

Objetivo: avaliar a prevalência e fatores relacionados ao consumo alimentar saudável e não saudável entre adolescentes escolares. Método: estudo de corte transversal, realizado com 634 escolares de 10 a 16 anos pertencentes a cinco escolas estaduais do município de Montes Claros, Minas Gerais, entre agosto/2016 e julho/2017. Resultados: houve prevalência do sexo feminino (60,1%). Com relação ao consumo de tabaco e álcool, 97,8% dos adolescentes negaram tabagismo e 92,4% negaram etilismo. Um total de 59,5% relatou praticar alguma atividade física e 95,1% dos adolescentes escolares têm uma autopercepção da saúde como sendo "excelente", "ótima" ou "boa". Os padrões de consumo alimentar saudável e não saudável estiveram associados à maior idade e ao consumo de álcool. Conclusão: o presente estudo contribui no sentido de estimar a ocorrência de marcadores de consumo alimentar de interesse para o monitoramento de fatores de risco para as doenças não transmissíveis.(AU)

Objective: to assess the prevalence and factors related to healthy and unhealthy food consumption among schoolchildren. Method: cross-sectional study, conducted with 634 schoolchildren aged 10 to 16 years belonging to five state schools in the municipality of Montes Claros, Minas Gerais, between August/2016 and July/2017. Results: there was a prevalence of female gender (60.1%). Regarding tobacco and alcohol consumption, 97.8% of adolescents denied smoking and 92.4% denied alcoholism. A total of 59.5% reported practicing some physical activity and 95.1% of school adolescents have a selfperception of health as "excellent", "great" or "good". Healthy and unhealthy food consumption patterns were associated with older age and alcohol consumption. Conclusion: the present study contributes towards estimating the occurrence of food consumption markers of interest for monitoring risk factors for non-communicable diseases(AU)

Objetivo: evaluar la prevalencia y los factores relacionados con el consumo de alimentos saludables y no saludables entre los escolares. Método: estudio transversal, realizado con 634 escolares de 10 a 16 años pertenecientes a cinco escuelas estatales del municipio de Montes Claros, Minas Gerais, entre agosto/2016 y julio/2017. Resultados: predominó el sexo femenino (60,1%). En cuanto al consumo de tabaco y alcohol, 97,8% de los adolescentes negó haber fumado y 92,4% negó haber consumido alcohol. Un 59,5% declaró practicar alguna actividad física y 95,1% de los adolescentes escolarizados tiene una autopercepción de la salud como "excelente", "estupenda" o "buena". Los patrones de consumo de alimentos saludables y no saludables se asociaron con la edad avanzada y el consumo de alcohol. Conclusión: el presente estudio contribuye a estimar la aparición de marcadores de consumo de alimentos de interés para el seguimiento de los factores de riesgo de las enfermedades no transmisibles(AU)

Perfil de usuários da atenção primária acerca do serviço de eletrocardiograma com laudo por telecardiologia / Perfil de usuarios de atención primaria sobre el servicio de electrocardiograma con informes de telecardiología / Profile of primary care users about the electrocardiogram service with telecardiology reports

Objetivo: identificar o perfil dos usuários da Atenção Primária acerca do serviço de eletrocardiograma com laudo por telecardiologia. Método: trata-se de um artigo oriundo de um trabalho de conclusão de curso (monografia), estudo descritivo, exploratório, documental, com abordagem quantitativa, realizado com 31 pacientes de um município de Minas Gerais que realizaram eletrocardiograma com laudo por telecardiologia em uma Estratégia de Saúde da Família. A busca dos dados foi realizada durante o 1º semestre de 2018, entre os meses de março e maio. Os dados foram discutidos conforme epidemiologia descritiva simples uni-variada não paramétrica e não probabilística. Resultados: houve prevalência do sexo feminino, idade média de 49,8 anos e sobrepeso. As comorbidades autorreferidas mais prevalentes foram a hipertensão e o histórico familiar. A dor torácica, queimação, pontadas, formigamento e pressão arterial descompensada foram as principais queixas para a realização do ame e o diagnóstico mais prevalente foi a normalidade. Conclusão: apesar da maior parte dos exames não terem evidenciado alterações, as variáveis socioeconômicas, metabólicas e genéticas constituem fator de risco para o desenvolvimento de doenças cardiovasculares.(AU)

Objective: to identify the profile of primary care users about the electrocardiogram service with telecardiology reports. Method: this is an article originated from a course conclusion work (monograph), this is a descriptive, exploratory, documentary study with a quantitative approach, conducted with 31 patients from a city from Minas Gerais who underwent electrocardiogram with telecardiology report in a Family Health Strategy. The data search was conducted during the 1st semester of 2018, between the months of March and May. The data were discussed according to simple descriptive epidemiology univariate non-parametric and non-probabilistic. Results: There was a prevalence of female gender, mean age of 49.8 years and overweight. The most prevalent self-reported comorbidities were hypertension and family history. Chest pain, burning, pricking, tingling and decompensated blood pressure were the main complaints for the exam and the most prevalent diagnosis was normality. Conclusion: despite the fact that most of the exams showed no alterations, socioeconomic, metabolic and genetic variables are risk factors for the development of cardiovascular diseases(AU)

Objetivo: identificar el perfil de usuarios de atención primaria sobre el servicio de electrocardiograma con informe de telecardiología. Método: este es un artículo resultante de un trabajo de finalización de curso (monografía), estudio descriptivo, exploratorio, documental, con enfoque cuantitativo, realizado con 31 pacientes de una ciudad de Minas Gerais a los que se les realizó electrocardiograma con informe de telecardiología en una Estrategia de Salud de la Familia. La búsqueda de datos se realizó durante el 1er semestre de 2018, entre los meses de marzo y mayo. Los datos se analizaron según la epidemiología descriptiva simple uni-variante no paramétrica y no probabilística. Resultados: hubo prevalencia de sexo femenino, edad media de 49,8 años y sobrepeso. Las comorbilidades autorreferidas más prevalentes fueron la hipertensión y la historia familiar. El dolor torácico, ardor, pinchazo, hormigueo y descompensación de la presión arterial fueron las principales quejas para realizar el examen y el diagnóstico más prevalente fue la normalidad. Conclusión: aunque la mayoría de los exámenes no mostraron cambios, las variables socioeconómicas, metabólicas y genéticas constituyen un factor de riesgo para el desarrollo de enfermedades cardiovasculares.(AU)

Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity.

BACKGROUND: Lifestyle could influence the course of hereditary ataxias, but representative data are missing. OBJECTIVE: The objective of this study was to characterize lifestyle in spinocerebellar ataxia type 3 (SCA3) and investigate possible associations with disease parameters. METHODS: In a prospective cohort study, data on smoking, alcohol consumption, physical activity, physiotherapy, and body mass index (BMI) were collected from 243 patients with SCA3 and 119 controls and tested for associations with age of onset, disease severity, and progression. RESULTS: Compared with controls, patients with SCA3 were less active and consumed less alcohol. Less physical activity and alcohol abstinence were associated with more severe disease, but not with progression rates or age of onset. Smoking, BMI, or physiotherapy did not correlate with disease parameters. CONCLUSION: Differences in lifestyle factors of patients with SCA3 and controls as well as associations of lifestyle factors with disease severity are likely driven by the influence of symptoms on behavior. No association between lifestyle and disease progression was detected. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Stomach cancer incidence and mortality in Greater Cuiabá, Mato Grosso, Brazil, 2000-2016 / Incidência e mortalidade por câncer de estômago na Grande Cuiabá, Mato Grosso, 2000-2016

ABSTRACT: Objective: To analyze the incidence and mortality trend of stomach cancer in the Greater Cuiabá, in the state of Mato Grosso, Brazil, from 2000 to 2016. Methods: The incidence information was obtained from the Population-Based Cancer Registry, and the mortality information from the Mortality Information System. Crude and standardized rates were calculated using the direct method, with the world population as reference. The trends were estimated using the Joinpoint regression method, according to sex and age group, and evaluated through the Annual Percent Change (APC) and the Average Annual Percent Change (AAPC). The Joinpoint Regression Program software, version 4.9.0.0, was used. Results: There was a decreasing incidence trend of stomach cancer in males (AAPC=-5.2; 95% confidence interval — 95%CI −7.7--2.6), in men aged 60 to 69 years (AAPC=-3.7; 95%CI −5.6--1.8) and in 70-79 years (AAPC=-3.7; 95%CI −5.6--1.8), as well as in women aged 50 to 59 years (AAPC=-5.2; 95%CI −7.8--2.6) and 80 years or older (AAPC=-5.2; 95%IC −7.8--2.6). The mortality initially increased in women aged 60-69 years (AAPC=28.4; 95%CI 9.7-50.4), decreased for 80 years or older (AAPC=-26.4; 95%CI −38.0--12.6) and stable for the other age groups and males. Conclusion: A decreasing incidence trend of stomach cancer was found among men and, when analyzed by age, among elderly males and adults and elderly females, as well as a stability in the mortality, with an initial variation in elderly women. The production of regional information supports the planning of local policies aimed at reducing the burden of disease and deaths, considering unequal risk conditions and access to health services.

RESUMO: Objetivo: Analisar a tendência da incidência e da mortalidade por câncer de estômago na Grande Cuiabá, Mato Grosso, entre 2000 e 2016. Métodos: Dados de casos novos e óbitos de residentes dos municípios Cuiabá e Várzea Grande foram obtidos no Registro de Câncer de Base Populacional e no Sistema de Informações sobre Mortalidade, respectivamente. Foram calculadas taxas brutas e padronizadas pelo método direto, utilizando-se a população mundial como referência. As tendências foram estimadas pelo método de regressão Joinpoint, segundo sexo e faixa etária, e avaliadas por meio da variação percentual anual (annual percent change — APC) e da variação percentual média anual (average annual percent change — AAPC). Utilizou-se o software Joinpoint Regression Program, versão 4.9.0.0. Resultados: Verificou-se tendência decrescente da incidência do câncer de estômago no sexo masculino (AAPC=-5,2; intervalo de confiança — IC95% −7,7--2,6), em homens com 60-69 anos (AAPC=-3,7; IC95% −5,6--1,8) e 70-79 anos (AAPC=-3,7; IC95% −5,6--1,8), bem como em mulheres com 50-59 anos (AAPC=-5,2; IC95% −7,8--2,6) e 80 anos ou mais (AAPC=-5,2; IC95% −7,8--2,6). A mortalidade apresentou, inicialmente, aumento em mulheres com 60-69 anos (AAPC=28,4; IC95% 9,7-50,4), redução para 80 anos ou mais (AAPC=-26,4; IC95% −38,0--12,6) e estabilidade nas demais faixas etárias e entre homens. Conclusão: Verificou-se redução da incidência de câncer de estômago em homens e, quando analisada por idade, entre homens idosos e mulheres adultas e idosas, bem como estabilidade na mortalidade, com variação inicial em idosas. A produção de informações regionais subsidia o planejamento de políticas locais que visem à redução da carga da doença e de óbitos, considerando condições desiguais de risco e acesso a serviços de saúde.

Incidence trend of five main causes of cancer, in greater Cuiabá, Mato Grosso, Brazil, 2000 to 2016 / Tendência da incidência dos cinco principais tipos de câncer na Grande Cuiabá, 2000 a 2016

ABSTRACT: Objective: To analyze the incidence trend of the five main causes of cancer, according to sex and age, in Greater Cuiabá, in the state of Mato Grosso, from 2000 to 2016. Methods: Incidence information was obtained from the Population-Based Cancer Registry, referring to the municipalities Cuiabá and Várzea Grande (RCBP — Cuiabá). Crude incidence rates were calculated and the five main types of cancer were selected: for males, prostate (C61), lung (C33-34), colorectal (C18-21), stomach (C16) and oral cavity cancer (C00-10); and for females, breast (C50), cervix (C53), colorectal (C18-21), lung (C33-34) and thyroid gland cancer (C73). Age-adjusted rates were calculated by the direct method, using the world population as reference. Trends were estimated using the Joinpoint method and evaluated by Annual Percent Change (APC) and Average Annual Percent Change (AAPC). The Joinpoint Regression Program software, version 8.3.6.1, was used. Results: During the period, there was a decreasing trend of lung (AAPC=-2.2; 95%CI −4.0--0.3) and stomach cancer (AAPC=-5.2; 95%CI −7.7--2.6) in men, and of cervix cancer (AAPC=-7.2; 95%CI −9.0--5.3) in women, and increasing for breast (AAPC=2.8; 95%CI 0.2-5.5) and thyroid cancer (AAPC=8.3; 95%CI 4.6-12.2). Conclusion: In Greater Cuiabá, we found a downward incidence trend among elderly men for prostate, lung and stomach cancer. Women are affected at younger age groups, with an upward trend for breast cancer and downward trend for cervix cancer.

RESUMO: Objetivo: Analisar a tendência da incidência das cinco principais causas de câncer, segundo sexo e faixa etária, na Grande Cuiabá, no estado de Mato Grosso, no período 2000 a 2016. Métodos: As informações da incidência foram obtidas no Registro de Câncer de Base Populacional referente aos municípios Cuiabá e Várzea Grande. Foram calculadas as taxas de incidência brutas e selecionados os cinco principais tipos de câncer: para o sexo masculino foram próstata (C61), pulmão (C33-34), colorretal (C18-21), estômago (C16) e cavidade oral (C00-10) e para o sexo feminino foram mama (C50), colo do útero (C53), colorretal (C18-21), pulmão (C33-34) e glândula tireoide (C73). As taxas foram padronizadas pelo método direto, utilizando-se população mundial como referência. As tendências foram estimadas pelo método de regressão joinpoint, segundo sexo e faixa etária, e avaliadas por meio da variação percentual anual (annual percent change — APC) e da variação percentual média anual (average annual percent change — AAPC). Utilizou-se o software Joinpoint Regression Program, versão 8.3.6.1. Resultados: No período, verificou-se tendência decrescente do câncer de pulmão (AAPC=-2,2; intervalo de confiança 95% [IC95%] −4,0--0,3) e estômago (AAPC=-5,2; IC95% −7,7--2,6), nos homens, e colo do útero (AAPC=-7,2; IC95% −9,0--5,3), nas mulheres, e crescente para mama (AAPC=2,8; IC95% 0,2-5,5) e tireoide (AAPC=8,3; IC95% 4,6-12,2). Conclusão: Na Grande Cuiabá, verificou-se tendência decrescente da incidência entre homens idosos para próstata, pulmão e estômago. Mulheres são acometidas em idades mais jovens, com tendência crescente para mama e decrescente para colo do útero.