Justice involvement prediction as individuals age: An age-graded evaluation of the public safety assessment.

OBJECTIVE: Some scholars have criticized pretrial assessments for perpetuating racial bias in the criminal legal system by offering biased predictions of future legal system outcomes. Although these critiques have some empirical support, the scholarship has yet to examine the predictive validity and differential prediction of pretrial assessments across individuals by their age. Following the guidance of the life-course literature, the present study serves as the first age-graded evaluation of the Public Safety Assessment (PSA) focused on assessing whether the predictive validity and scoring predictions of the tool vary across the lifespan. HYPOTHESES: We expected that the predictive validity of the PSA scores would vary across the lifespan, such that the PSA underpredicts for younger individuals and overpredicts for older individuals. METHOD: The present study relied on pretrial information collected from 31,527 individuals during the Advancing Pretrial Policy and Research project. Logistic regression models were estimated to evaluate the differential prediction of the PSA for individuals ranging from 18 to 68 years of age. The results of bivariate models were used to produce area under the curve estimates at each year of age. RESULTS: The results of the present study provided some evidence that the PSA differentially predicted pretrial outcomes for individuals from 18 to 68 years of age. Specifically, the predictive validity of the New Criminal Arrest and the New Violent Criminal Arrest scales appears to improve as individuals become older, suggesting that these instruments are better able to predict pretrial outcomes for older individuals relative to younger individuals. CONCLUSION: The results suggest that the PSA is a valid predictor of pretrial outcomes and that the predictive validity of some PSA scores is impacted by age. These findings suggest that the age of the defendant should be accounted for when interpreting the new criminal arrest and new violent criminal arrest scores. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Metrenperone enhances collagen turnover and remodeling in the early stages of healing of tendon injury in rabbit.

INTRODUCTION: This study evaluated the effects of metrenperone on healing of unilateral, collagenase-induced lesions in the Superficial Digital Flexor Tendons (SDFT) of rabbits. METHODS: After controlled injury of the left SDFT, nine rabbits received daily treatment with metrenperone for 28 days. Another nine were untreated controls; in both groups the contra-lateral tendons served as uninjured controls. Histological and ultrastructural changes, mechanical properties, dry weight, collagen content, and amount of DNA in healing and control tendons were assessed 28 days after injury. RESULTS: Restoration of structural hierarchy was more organized in treated than in untreated tendons while cellularity was greater in the latter. At the ultrastructural level, collagen in treated lesions was predominantly in the form of small-diameter, new fibrils, with few large, old fibrils; in untreated lesions there was a high proportion of large, old fibrils but relatively few small, new ones. The amount of DNA in untreated injuries was much greater than in normal tendons, while in treated lesions it was not significantly different from that of uninjured controls. There were no significant differences in total collagen, stiffness and ultimate strength of injured, treated, and untreated tendons 28 days after injury. Both were significantly weaker than their corresponding contralaterals. CONCLUSIONS: The findings suggest that metrenperone had positive effects on collagen turnover, remodelling, and organization during acute inflammation and fibroplasia. Provided that the new fibrils subsequently matured in a normal manner, mechanical characteristics of the organized scar should be better than those of an untreated lesion.

Effects of a serotonin S2-receptor blocker on healing of acute and chronic tendon injuries.

The beneficial effects of serotonin S(2)-receptor blockers on healing skin and muscle ulcers and refractory lesions such as leprosy and diabetic and ischemic ulcers have been reported previously, but their mechanisms of actions are not clear. The present study sought to elucidate the action of an S(2)-receptor blocker, metrenperone, on the healing of collagenase-induced injuries in superficial digital flexor tendons of two groups of rabbits. In one group, oral and topical therapy for 28 days with metrenperone, was started within 48 hr of a single acute injury. The animals were then left untreated for another 60 days, when it was found that most of the morphological, biochemical, and biomechanical characteristics of the healed tendons matched those of their normal uninjured controls. Injured, untreated controls showed poor healing. In the second group of animals, tendon injury was induced by four separate injections of collagenase at weekly intervals. The rabbits were left for another 60 days, before being treated with metrenperone for 26 days. This delayed treatment had no apparent effect on the biomechanical, biochemical, or morphological characteristics of the healing tendons. It appeared that metrenperone had a significant effect on collagen turnover and organization of scar tissue, but only while the inflammatory and fibroplastic processes were active in the early stages of healing. S(2)-receptor blockers may, therefore, be of potential value for modulating repair in acutely injured collagenous tissue.

Energy metabolism in mammalian brain during development.

Production of energy for the maintenance of ionic disequilibria necessary for generation and transmission of nerve impulses is one of the primary functions of the brain. This review attempts to link the plethora of information on the maturation of the central nervous system with the ontogeny of ATP metabolism, placing special emphasis on variations that occur during development in different brain regions and across the mammalian species. It correlates morphological events and markers with biochemical changes in activities of enzymes and pathways that participate in the production of ATP. The paper also evaluates alterations in energy levels as a function of age and, based on the tenet that ATP synthesis and utilization cannot be considered in isolation, investigates maturational profiles of the key processes that utilize energy. Finally, an attempt is made to assess the relevance of currently available animal models to improvement of our understanding of the etiopathology of various disease states in the human infant. This is deemed essential for the development and testing of novel strategies for prevention and treatment of several severe neurological deficits.