Probable cutaneous adverse drug reaction due to a cannabidiol-containing hemp oil product in a dog.

BACKGROUND: Cannabidiol (CBD) in hemp oil has become a widely used product in veterinary medicine. To date, there have been no reports of cutaneous adverse events associated with CBD-containing oil in the veterinary literature. CLINICAL SUMMARY: A 4-year-old castrated male Labrador retriever presented with pad sloughing and rapidly progressive cutaneous and mucosal ulceration within five days of administering an oral CBD oil product. Histopathological findings in combination with cutaneous signs were consistent with Stevens-Johnson syndrome. All lesions completely resolved after discontinuation of the hemp oil in addition to a 12 day course of cephalexin and prednisone. Given the lack of alternative causes including other medications, an adverse drug event was deemed probable according to the Naranjo algorithm. CONCLUSIONS AND CLINICAL IMPORTANCE: To the best of the authors' knowledge, this is the first report of suspected cutaneous adverse drug reaction to a CBD-containing hemp oil product.

Systemic hypertension in a dog with a functional thyroid gland adenocarcinoma.

CASE DESCRIPTION: A 12-year-old 21.9-kg (48.48-lb) spayed female Alaskan Malamute with a long-term history of panting, polydypsia and polyuria, weight loss, hind limb weakness, and a decrease in appetite was evaluated for hypertension. CLINICAL FINDINGS: Use of Doppler sphygmomanometry revealed a systolic blood pressure of 250 mm Hg (mean value for 5 consecutive measurements). Palpation of the ventral cervical region revealed a fixed asymmetric mass in the area of the lobes of the thyroid gland. The portion of the mass on the right side was approximately 2 x 2 cm, whereas the portion of the mass on the left side was approximately 1 x 1.5 cm. Hyperthyroidism was diagnosed on the basis of high serum thyroxine concentrations. Thyroidectomy of both lobes of the gland was performed. Histologic examination revealed a bilateral, multilobulated, and encapsulated thyroid gland adenocarcinoma. TREATMENT AND OUTCOME: Thyroidectomy of both lobes of the gland was performed with clinical resolution of hypertension. The dog was treated postoperatively with chemotherapeutics, including doxorubicin and carboplatin, and external beam radiation. Calcium and thyroxine homeostasis fluctuated; however, the dog finally achieved concentrations within the respective reference ranges through the administration of calcitriol, calcium carbonate, and levothyroxine. CLINICAL RELEVANCE: This report describes concurrent hypertension in a dog with a functional thyroid gland adenocarcinoma with subsequent return of blood pressure values to within reference ranges after thyroidectomy.