[Epidemiological and pathological profile of colorectal cancer: about 36 cases]. / Profil épidémiologique et anatomopathologique du cancer colorectal: à propos de 36 caswe.

Colorectal cancer is classified among the most common cancers in the world (after breast cancer and prostate cancer) and it is the second digestive tract cancer in Morocco after stomach cancer. However, its incidence in our country is lower than that of western countries (2.5 to 3.3 / 100 000 ha) but it coincides with that of Maghreb countries where this cancer affects young subjects in 27% of cases. Colorectal cancer (CRC) is one of the best examples of multistep carcinogenesis. Knowing the anatomopathological characteristics of CRC will certainly affect our therapeutic approaches. We conducted a retrospective epidemiological and anatomopathological study in the Department of Visceral Surgery at the Military Hospital Moulay Ismail, Meknes over a period of 5 years from January 2012 to December 2016. The study involved 36 patients: 14 women and 22 men. The aim of this study was to analyze the epidemiological profile and the anatomopathological features of colorectal cancers. The analysis of our results shows a specific epidemiological profile which is characteristic of a type of colorectal cancer affecting younger subjects, mainly male patients. Sporadic carcers are largely predominant, occurring mainly in the rectosigmoid region. A low degree of differentiation of adenocarcinomas with mucinous features is correlated with advanced TNM and Aster Coller staging and with lymph node status with poor prognosis. This multidisciplinary approach will be a novelty at national level, thus making our structure of clinical practice and research one of the centres for multidisciplinary management of colorectal cancer in Morocco.

An unusual presentation of neurosarcoidosis with progressive hearing loss.

Sarcoidosis is a granulomatous disease of unknown etiology that can involve several organ system. Neurological manifestations are not common and mostly include cranial neuropathies. However, auricular disorders are rare and exceptionally inaugural. We describe the case of a 46-year-old lady presented with hearing loss as the initial manifestation of sarcoidosis, and aim to raise awareness of this condition, that is often associated with significant morbidity.

[Granulomatous spondylodiscitis: due mainly to tuberculosis but lymphoma cannot be excluded]. / Spondylodiscite granulomateuse: surtout la tuberculose mais ne pas omettre le lymphome.

Lower back pain is due to multiple etiologies that make diagnosis difficult. Primitive spinal lymphoma is rare and its diagnosis often requires ultrasound-guided biopsy. A 30-year old man hospitalized for inflammatory lumbago evolving within the context of an impaired general condition. Phisical examination revealed pain on palpation of the L2-L3 vertebral apophysis without peripheral tumor syndrome. Laboratory tests showed an inflammatory syndrome. Morphological assessment was in favour of a spondylodiscitis. The first biopsy showed granulomatous osteitis.Clinical and radiological worsening during antibacillary treatment led to reconsider the original diagnosis and a second biopsy confirmed the diagnosis of lymphoma. The diagnosis of skeletal tuberculosis in particular spinal tuberculosis requires bacteriological or histological confirmation in order not to overlook a primitive bone lymphoma.

[An exceptional association between retroperitoneal dedifferentiated liposarcoma and well differentiated pericolonic liposarcoma: about a case]. / Une association exceptionnelle d'un liposarcome dédifférencié retro péritonéal et d'un liposarcome bien différencié péri colique: à propos d'un cas.

Liposarcoma is an extremely rare malignant adipose mesenchymal tumor. World Health Organization classifies liposarcomas into five subtypes: well differentiated, myxoid, pleomorphic, dedifferentiated and mixed. The association between multiple and synchronous location of several subtypes of liposarcomas is exceptional. Only 34 cases have been reported in the literature. We report the case of synchronous association between retroperitoneal dedifferentiated liposarcoma and two small well-differentiated lipoma-like pericolic liposarcomas. Anatomopathological aspects, therapeutic options and prognostic factors of liposarcomas have been reviewed in this study.

Upper urinary tract lipoma: A case report.

Upper urinary tract (UUT) benign tumours are rare. We present a case of UUT lipoma in a 41-year-old man with left flank pain. A computed tomographic urography scan revealed an irregular thickening of the left renal collecting system wall extending from the upper calices to the renal pelvis. The diagnosis of UUT was made and the patient underwent a nephroureterectomy with bladder cuff excision, as standard treatment. However, macroscopic and histological examination revealed a lipomatous tumour with no sign of malignancy. To our knowledge this is the first reported case of its kind of a UUT managed first with a minimally invasive approach.

Diagnosis and management challenge of a granular cell astrocytoma of the pineal region: case report.

Granular cell astrocytoma (GCA) is a rare type of infiltrative brain tumor with most reported cases occurring in the suprasellar region. A pineal localization is extremely rare, with only 4 previously reported cases in the literature. The authors describe the case of a 16-year-old boy who developed signs of increased intracranial pressure and Parinaud syndrome. Cranial CT and MRI revealed a well-demarcated and enhanced mass in the pineal region accompanied by obstructive hydrocephalus. Subtotal resection was performed via a subtemporal approach. A histological diagnosis of GCA was made. Three years after surgery, the patient was alive and well without adjuvant therapy, and serial MRI showed no signs of progression of a small residual tumor. After a thorough review of the different epidemiological, clinical, and imaging features; treatments; and prognoses of GCAs in other intracranial localizations, the authors analyzed features of this tumor in the pineal region.

Adenoid cystic carcinoma of cervix in younger women: report of two new cases.

Adenoid cystic carcinoma is a malignant epithelial neoplasm derived from the salivary glands. Primary adenoid cystic carcinoma of the cervix is extremely rare, accounting for less than 1% of all cervical carcinomas. Its origin is debatable. It generally presents in elderly age group, however only twenty three cases have been reported in women less than age 45 years old. In this paper we report two new cases of primary adenoid cystic carcinoma in younger women and include the cytopathology and histopathology findings. A 36, 41 year-old women were admitted with signs and symptoms suggestive of a cervical cancer. Speculum examination showed a firm mass in the uterine cervix. The diagnosis of adenoid cystic carcinoma was confirmed by the histopathology examination of the biopsy specimen in the two patients, which characteristically revealed the presence of a cribriform pattern and cylindromatous structures of the tumor cells, adhered around hyaline stoma. They were managed successfully by concurrent radiotherapy. Adenoid cystic carcinoma of the cervix is a rare disease. It usually occurs in an elderly age group. We report these two cases because of its rarity in young patients, with description of illustrative pathology and discussion on the histological diagnosis.

Multiple lytic lesions of the spine: a rare diagnosis of eosinophilic granuloma in an adult: a case report.

Eosinophilic granuloma (EG) is a rare benign osteolytic lesion observed rarely in adults, with only some 18 cases of spinal location reported in the literature. We present an unusual variant of EG in a 23-year-old man with radiological features of multiple spinal lytic lesions which was evocated of metastatic processes. A surgically transpedicular biopsy of the thoracic collapsed vertebrae with posterior stabilization was made. Histological examination of the tissue showed features of eosinophilic granuloma. The clinical and radiological findings of EG present dilemmas of both diagnosis and treatment. The etiology is unclear and the therapeutic approach is still controversial.