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1.
Radiol Oncol ; 55(3): 259-267, 2021 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-34051709

RESUMO

BACKGROUND: The aim of the study was to derive and compare metabolic parameters relating to benign and malignant pulmonary nodules using dynamic 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG) PET/CT, and nodule perfusion parameters derived through perfusion computed tomography (CT). PATIENTS AND METHODS: Twenty patients with 21 pulmonary nodules incidentally detected on CT underwent a dynamic 18F-FDG PET/CT and a perfusion CT. The maximum standardized uptake value (SUVmax) was measured on conventional 18F-FDG PET/CT images. The influx constant (Ki ) was calculated from the dynamic 18F-FDG PET/CT data using Patlak model. Arterial flow (AF) using the maximum slope model and blood volume (BV) using the Patlak plot method for each nodule were calculated from the perfusion CT data. All nodules were characterized as malignant or benign based on histopathology or 2 year follow up CT. All parameters were statistically compared between the two groups using the nonparametric Mann-Whitney test. RESULTS: Twelve malignant and 9 benign lung nodules were analysed (median size 20.1 mm, 9-29 mm) in 21 patients (male/female = 11/9; mean age ± SD: 65.3 ± 7.4; age range: 50-76 years). The average SUVmax values ± SD of the benign and malignant nodules were 2.2 ± 1.7 vs. 7.0 ± 4.5, respectively (p = 0.0148). Average Ki values in benign and malignant nodules were 0.0057 ± 0.0071 and 0.0230 ± 0.0155 min-1, respectively (p = 0.0311). Average BV for the benign and malignant nodules were 11.6857 ± 6.7347 and 28.3400 ± 15.9672 ml/100 ml, respectively (p = 0.0250). Average AF for the benign and malignant nodules were 74.4571 ± 89.0321 and 89.200 ± 49.8883 ml/100g/min, respectively (p = 0.1613). CONCLUSIONS: Dynamic 18F-FDG PET/CT and perfusion CT derived blood volume had similar capability to differentiate benign from malignant lung nodules.


Assuntos
Fluordesoxiglucose F18 , Neoplasias Pulmonares/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Compostos Radiofarmacêuticos , Nódulo Pulmonar Solitário/diagnóstico por imagem , Idoso , Volume Sanguíneo , Estudos de Viabilidade , Feminino , Humanos , Achados Incidentais , Iopamidol/administração & dosagem , Iopamidol/análogos & derivados , Neoplasias Pulmonares/irrigação sanguínea , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Estudos Prospectivos , Fluxo Sanguíneo Regional , Nódulo Pulmonar Solitário/irrigação sanguínea , Nódulo Pulmonar Solitário/patologia , Tomografia Computadorizada por Raios X
2.
Chest ; 126(6): 2020-2, 2004 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-15596708

RESUMO

Mediastinal lymph node metastases in patients with non-small cell lung cancer are a critical determinant of operability. Mediastinoscopy is invasive, requires general anesthesia, and carries appreciable morbidity. The development of minimally invasive techniques for the pathologic staging of lung cancer is important. We report a one-stop minimally invasive method for the pathologic diagnosis and staging of the majority of the mediastinum under conscious sedation using a novel prototype endobronchial ultrasound probe with a real-time fine-needle aspiration (FNA) facility in combination with conventional endoscopic ultrasound FNA.


Assuntos
Biópsia por Agulha Fina/métodos , Carcinoma Pulmonar de Células não Pequenas/diagnóstico , Carcinoma Pulmonar de Células não Pequenas/secundário , Endoscopia , Endossonografia , Neoplasias Pulmonares/patologia , Linfonodos/patologia , Mediastino , Idoso , Biópsia por Agulha Fina/instrumentação , Humanos , Linfonodos/diagnóstico por imagem , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Ultrassonografia de Intervenção
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