[Use of gas chromatography--mass spectrometry system in toxicology]. / Aplikace systému plynové chromatografie - hmotové spektrometrie v toxikologii

In the presented paper experiences with the practical usage of gas chromatography - mass spectrometry system are given. Cases of the identification of forbidden doping drugs and some significant groups of medicaments are described. The possibility of the identification of drug metabolites and interfering substances is pointed as well. Examples of chemical ionization usage are given from literature papers. This work points out the advantages of both methods for the identification of drugs in biological material. The priority and possibility of both procedures are evaluated critically.

[Use of gas chromatography--mass spectrometry in toxicology]. / Aplikace systemu plynové chromatografie - hmotové spektrometrie v toxikologii

In the present paper, discussion has been focused upon the problem of identifying toxic substances with the aid of the GC/MS system, i.e. gas chromatography - mass spectrometry. Factors involved in a successful combination of a gas chromatography with a mass spectrophotometer have been pointed out. In addition attention has been drawn to the two various ways of obtaining the spectra, i.e. the classic EI spectra and those obtained during chemical ionization, the mode of performing mass fragmentography and, last, the importance and characteristic features of the computer-controlled GC/MS systems.