RESUMO
In immature Strain 13 guinea pigs sensitized to syngeneic spinal cord, a chronic allergic encephalomyelitis is elicited reminiscent of demyelinating diseases of man and which features relapses or progressive downhill course and extensive areas of demyelination in the central nervous system. However, juvenile recipients of syngeneic lymphocytes from similarly sensitized juveniles show only the acute form of experimental allergic encephalomyelitis. Neuropathologically, the CNS of affected animals displayed mild changes only and minimal demyelination. These observations indicate that the age-dependent differences seen between the acute disease of adults and the chronic disease of juveniles may be due to differences in availability of modulating or reparatory factors, rather than differences in the central nervous system organ or in the immune response itself.
Assuntos
Encefalomielite Autoimune Experimental/imunologia , Cobaias/fisiologia , Imunização Passiva , Doença Aguda , Animais , Sistema Nervoso Central/patologia , Doença Crônica , Encefalomielite Autoimune Experimental/patologia , Encefalomielite Autoimune Experimental/transmissão , Humanos , Doadores de TecidosRESUMO
Clinical and neuropathological studies of a case of congenital intramedullary spinal dermoid tumor in a patient with typical Arnold-Chiari malformation have been presented. The bulk of the tumor mass was located at C7 level and extended downward for about 3 cm. Numerous well formed hairs were grossly noted within the lesion. Microscopic examination revealed the presence of keratin squams, hair and hair follicles in chronic inflammatory granulation tissue. These histological features suggest that the dermoid has ruptured and therefore the cyst walls could not be identified as such but the content induced prominent chronic inflammatory granulomatous reaction. The rarity of the lesion, especially at the cervical and upper thoracic level and its unique association with an Arnold-Chiari malformation are discussed.
Assuntos
Malformação de Arnold-Chiari/complicações , Cisto Dermoide/complicações , Neoplasias da Medula Espinal/complicações , Malformação de Arnold-Chiari/patologia , Autopsia , Cisto Dermoide/congênito , Cisto Dermoide/patologia , Humanos , Lactente , Masculino , Meningomielocele/complicações , Meningomielocele/patologia , Neoplasias da Medula Espinal/congênito , Neoplasias da Medula Espinal/patologiaRESUMO
Detailed comparative ultrastructural examination of multiple sclerosis (MS) plaques, inflammatory CNS lesions from adreno-leukodystrophy(A-LD), tissue from a case of chronic granulomatous meningitis, biopsy samples of necrotic cerebral cortex and CNS tissue from a case of Kuf's disease (adult-type ceroid lipofuscinosis), has revealed that the intranuclear filamentous material previously thought to be related to a viral infection in MS is a non-specific finding. These intranuclear strands were, however, found in greatest frequency in the acute lesions of MS and were absent from chronically demyelinated areas. The macrophages, lymphocytes and fibrocytes containing filamentous material in the nuclei were mainly perivascular. In A-LD, some macrophages in active lesions contained similar nuclei, and in Kuf's disease they were present in some glial cells in the cerebral cortex.