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2.
Ter Arkh ; 88(7): 109-113, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27459624

RESUMO

The paper describes 4 cases of laparoscopic splenectomy in pregnant women with immune thrombocytopenic purpura. No complications of surgery were noted in all the patients. The postoperative period was marked by sustained clinical and hematological remission that made it possible to discontinue prednisolone therapy and to ensure an uncomplicated course of pregnancy and labor.


Assuntos
Laparoscopia/métodos , Complicações na Gravidez/cirurgia , Púrpura Trombocitopênica Idiopática/cirurgia , Esplenectomia/métodos , Adulto , Feminino , Humanos , Gravidez , Resultado da Gravidez
3.
Bioorg Khim ; 41(3): 292-8, 2015.
Artigo em Russo | MEDLINE | ID: mdl-26502605

RESUMO

The influence ofvarious surfactants (anionic sodium dodecyl sulfate, SDS, cationic dodecyltrimethylarnmonium bromide, DTAB, and zwitterionic cocoamidopropylbetaine, CAPB) on the activity of the chicken egg lysozyme is investigated. Lysis of Gram-positive bacteria by the enzyme was carried out at pH 7.2 and ionic strength of 0.15 M. It was found that at low SDS and DTAB concentrations (less than 1 x 10(-5) M) the bacteriolytic activity increases by 30-140%. At higher concentrations (1 x 10(-5) - 1 x 10(4) M) the activity returns to the level observed in the absence of the surfactants. The elevated activity correlated with the formation of hydrophobic lysozyme-surfactant complexes. Introduction of CAPB at concentrations above 1 x 10(-5) M sig, nificantly diminished the bacteriolytic activity due to CAPB induced aggregation of lysozyme.


Assuntos
Bacteriólise/efeitos dos fármacos , Micrococcus luteus/efeitos dos fármacos , Muramidase/metabolismo , Animais , Betaína/análogos & derivados , Betaína/farmacologia , Galinhas , Muramidase/efeitos dos fármacos , Compostos de Amônio Quaternário/farmacologia , Dodecilsulfato de Sódio/farmacologia , Propriedades de Superfície
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