1.
Bioorg Med Chem Lett
; 21(8): 2278-82, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21420297
RESUMO
A novel series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. A basic nitrogen within the tether linking the aniline nitrogen atom to a tetrahydroindolone moiety allowed access to compounds with good physical properties. Important structure-activity relationship information was obtained from this series which led to the discovery of a soluble and stable compound which is potent in an Hsp90 binding and cell-proliferation assay.