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Nanomedicine (Lond) ; 18(10): 789-801, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-37199266

RESUMO

Aims: The development of rapamycin (RAP) and resveratrol (RSV) coloaded liposomes (RAP-RSV-LIP) for breast cancer therapy. Materials & methods: Liposomes were prepared using a high-pressure homogenization technique and evaluated according to their physicochemical characteristics, cellular uptake and cytotoxicity against tumoral and normal cells. Results & conclusion: The RAP-RSV-LIP showed negative surface charge, size around 100 nm, low polydispersity and high encapsulation efficiency for RAP and RSV (58.87 and 63.22%, respectively). RAP-RSV-LIP showed great stability over 60 days and a prolonged drug-release profile. In vitro studies indicated that RAP-RSV-LIP were internalized in an estrogen receptor-positive human breast cancer cell line (MCF-7, 34.2%) and improved cytotoxicity when compared with free drugs. Therefore RAP-RSV-LIP showed great antitumoral potential against breast cancer cells.


Assuntos
Neoplasias da Mama , Lipossomos , Humanos , Feminino , Resveratrol/farmacologia , Lipossomos/uso terapêutico , Sirolimo/farmacologia , Sirolimo/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Antioxidantes/uso terapêutico , Linhagem Celular Tumoral
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