RESUMO
The value of the simultaneous estimation of serum carcino-embryonic antigen (CEA) and C-reactive protein (CRP) concentrations in staging patients with colorectal neoplasias was evaluated. The study included 95 patients with benign or malignant epithelial tumors of colon and rectum. The simultaneous negative values of CEA and CRP were able to exclude stage D tumors with a specificity of 92.6% (P less than 0.001). Simultaneously positive values of CEA and CRP were able to diagnose stage C or D tumors with a specificity of 92.1% (P less than 0.001). It is concluded that the combination of CEA and CRP tests can substantially contribute to the preoperative staging and assessment of the extent of colorectal cancer.
Assuntos
Proteína C-Reativa/análise , Antígeno Carcinoembrionário/sangue , Neoplasias Colorretais/sangue , Neoplasias Colorretais/patologia , Adenocarcinoma/sangue , Adenocarcinoma/patologia , Adenoma/sangue , Adenoma/patologia , Neoplasias Colorretais/imunologia , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Testes de Fixação do Látex , Masculino , Estadiamento de Neoplasias/métodos , Valor Preditivo dos Testes , Sensibilidade e EspecificidadeRESUMO
In 55 patients with benign or malignant neoplasias of the large bowel, serum carcinoembryonic antigen (CEA), C-reactive protein (CRP), alpha 1-antitrypsin (AAT), alpha 1-acid glycoprotein (AAG) levels, and the percentage of serum protein electrophoretic components were measured. Statistical analysis showed significant correlations between serum CEA, CRP, AAG, and AAT levels and the percentage of serum beta-globulins with the stage of the disease. Multivariate discriminant analysis gave a final prognostic model that included serum CEA, CRP, and AAT levels and the percentage of the serum beta-globulins with a significance of P less than 0.000001. The authors conclude that the serum acute-phase protein levels, in combination with serum CEA concentrations, have a definite role in the preoperative staging of large bowel cancer.
Assuntos
Proteínas de Fase Aguda/análise , Antígeno Carcinoembrionário/análise , Neoplasias Colorretais/sangue , Proteína C-Reativa/análise , Neoplasias Colorretais/patologia , Neoplasias Colorretais/cirurgia , Feminino , Humanos , Masculino , Análise Multivariada , Recidiva Local de Neoplasia/sangue , Estadiamento de Neoplasias , Orosomucoide/análise , Cuidados Pré-Operatórios , Prognóstico , alfa 1-Antitripsina/análiseRESUMO
Adenomyomas are rare pseudotumors of the extrahepatic biliary tract. Their microscopic appearance does not differ significantly from similar malformations of the peritoneal cavity. We describe a patient who presented with obstructive jaundice and who was treated successfully with a surgical resection and a hepaticojejunal anastomosis.