An ultra-low-molecular-weight heparin, fondaparinux, to treat retinal vein occlusion.

Retinal vein occlusions may decrease visual acuity. There is no known therapy to treat ocular thrombosis. The authors used fondaparinux, an ultra-low-molecular-weight heparin, to treat 13 consecutive cases of recent-onset retinal vein occlusions. Two patients with renal insufficiency were not included. Eight central retinal vein occlusions and 5 branch retinal vein occlusions in 13 patients were treated with subcutaneous fondaparinux 2.5 mg once a day. The patients were seen every 2 weeks. Macular edema was treated with intravitreal injections of anti-vascular endothelial growth factor or steroids. Two patients elected to discontinue treatment. Of the remaining 11, 9 occlusions resolved in 1.5 to 13.5 months with rapid resolution of retinal edema and hemorrhage as soon as the occlusions resolved. One patient had a retinal vein that was still occluded after 8 months of therapy and 1 had retinal vein occlusion that partially resolved after 15 months of treatment. Of the 9 eyes with occlusions that resolved, visual acuity improved in 7. In 2, visual acuity decreased due to macular ischemia. Occlusion recurred in 1 2.5 months after the suspension of initial treatment. This patient is again being treated with fondaparinux 2.5 mg. No hemorrhaging occurred. Fondaparinux 2.5 mg can be given subcutaneously once a day to patients with recent-onset retinal vein occlusions without renal insufficiency. An occlusion may take a number of months to resolve. Once the vein occlusion has resolved, retinal edema and hemorrhage rapidly resolve and vision improves. Macular edema should be treated while waiting for the vein occlusion to resolve.

Retinal Angiomatous Proliferation Successfully Treated with Indocyanine Green Dye-Enhanced Photocoagulation.

This case series presents the use of indocyanine green dye-enhanced photocoagulation (ICG-DEP) for the treatment of retinal angiomatous proliferation (RAP). Five RAP lesions in 4 eyes of 3 patients were identified by fluorescein and indocyanine green dye angiography. The RAP lesions were treated with focal ablation of the intraretinal component using a ICG-DEP protocol. The 810-nm infrared laser in the pulsed millipulsed mode was used. The visual acuity and angiographic findings in the 3 patients with a follow-up from 18 months to 4 years are reported. The five RAP lesions were closed angiography in the 4 eyes of the 3 patients. All of the eyes had visual improvement for at least 8 months. In one stage 3 RAP lesion, there was visual improvement for 8 months until the choroidal neovascular membrane grew again. In this limited series, the procedure appeared to be safe and well tolerated with stable or improved visual acuity.