STUDY OF THE HYGIENIC CHARACTERISTICS OF THE ORAL CAVITY UNDER THE COMPLEX EFFECT OF PHOTODYNAMIC THERAPY AND TSKALTUBO SPRING WATER RADON HORMESIS.

The goal is to study the method of photodynamic therapy, which has become widespread in recent decades. This method of treatment has gained popularity in the treatment of both oncological and non-oncological inflammatory diseases in dentistry and other medical fields. We can conclude that the complex action of Rada Dent and Tskaltubo water (inhalation of Tskaltubo water and its use as rinses) leads to a gradual reduction and eventual eradication of the inflammatory process in the case of periodontitis. This can be explained by the unique properties that are characteristic of "Rada Dent" and Tskaltubo water. As we have seen, the above biochemical indicators are the determinants of periodontitis in patients with periodontitis, they are markers of the degree of periodontitis and we have clearly seen the complex action. High efficiency of "Rada Dent" and radon in the water of Tskaltubo - normalization of the action of oral enzymes, slowing down the inflammatory processes in the oral cavity and finally eradication. It is these unique properties that have become triggering the treatment and inhibit the initial stage of periodontitis.

[ALKALOIDS OF UNDERGROUND PARTS OF GEORGIAN FLORA'S ACONITUM ORIENTALE MILL. AND ACONITUM NASUTUM FISCH. EX REICHEMB AND THEIR BIOLOGICAL ACTIVITY].

The aim of research was to study underground parts of Aconitum orientale Mill and Aconitum nasutum Fisch exReichemb for the composition of biological active diterpenic alkaloids. The research object was underground parts of Aconitum species. Alkaloids sum was received from raw-material which was alkalined beforehand with chloroform extraction. From the results of research we established, that both species of Georgian flora's Aconitum contains alkaloids: lappaconitine, aconitine, karakoline. Underground parts of Aconitum orientale and Aconitum nasutum differ from eath other with composition of alkaloids spectrum. Underground parts of Aconitum orientale contains bases: ranaconitine, gigactonine, licoctonine, but underground parts of Aconitum nasutum contains: talitizamine, kamakonine, aconosine. Alkaloids' summary substances, which were received from underground parts of Aconitum species spread in Georgia, showed selective cytotoxic activity towards A-549 (lung carcinoma), DLD-1 (intestine adenocarcinoma), WS-1 (human normal fibroblasts).