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1.
Eur Ann Allergy Clin Immunol ; 52(1): 39-44, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31594295

RESUMO

Summary: We describe a female diagnosed with non-allergic asthma. On March 24, 2016, examination of the skin-biopsy specimen revealed dense eosinophilic infiltration, and the Fip-1-like 1-platelet-derived growth factor receptor a fusion gene in peripheral blood mononuclear cells was negative. She was diagnosed with idiopathic hypereosinophilic syndrome. She was treated with intravenous methylprednisolone (MPSL), and subsequent oral MPSL. Then, she started to receive a monthly mepolizumab in June 2016, and successfully withdrew from daily use of oral MPSL. The patient has a mother diagnosed with non-allergic asthma. In February 2005, she was diagnosed with eosinophilic granulomatosis with polyangitis because of elevated antineutrophil myeloperoxidase antibodies, and the skin-biopsy specimen findings. She started to receive a monthly mepolizumab in June 2016. Corticosteroid therapy was successfully withdrawn. To our knowledge, this is the first case report suggesting mepolizumab may be a useful treatment for familial clustering of hypereosinophilic diseases.


Assuntos
Antiasmáticos/uso terapêutico , Anticorpos Monoclonais Humanizados/uso terapêutico , Asma/tratamento farmacológico , Síndrome Hipereosinofílica/tratamento farmacológico , Feminino , Humanos , Japão , Pessoa de Meia-Idade , Linhagem , Resultado do Tratamento
2.
Surg Today ; 28(11): 1154-9, 1998.
Artigo em Inglês | MEDLINE | ID: mdl-9851623

RESUMO

Although dynamic cardiomyoplasty (DCMP) is currently being evaluated as an alternative to end-stage congestive heart failure, the overall results of DCMP are variable and inconclusive. We evaluated the effect of classic DCMP on systolic and diastolic cardiac function in normal heart using reliable indicators which minimize the influences of load conditions. Six experimental dogs were evaluated with the acute nonpreconditioning model. The slope of the linear preload recruitable stroke work relationship (Mw) showed a significant increase with latissimus dorsi muscle (LDM) stimulation (postwrap non-stimulation 59.1+/-6.3, postwrap stimulation 98.6+/-9.7 erg cm(-3) x 10(3); P < 0.01), and the x-intercept (V0) was unchanged; these were utilized as the indicators of left ventricular systolic function. The constant of pressure decay (tau) increased after LDM wrap (prewrap 45.8+/-6.0, postwrap nonstimulation 69.3+/-10.3, postwrap stimulation 72.3+/-13.9 ms; P < 0.05), and the peak filling rate was unchanged after LDM wrap, which were utilized as the indicators of diastolic function. We concluded that classic dynamic cardiomyoplasty is effective in assisting systolic cardiac function, but may to some degree have a detrimental effect on the diastolic cardiac function.


Assuntos
Cardiomioplastia , Insuficiência Cardíaca/fisiopatologia , Insuficiência Cardíaca/cirurgia , Função Ventricular Esquerda , Animais , Diástole , Modelos Animais de Doenças , Cães , Volume Sistólico , Sístole , Resultado do Tratamento
3.
Nihon Kyobu Geka Gakkai Zasshi ; 44(4): 570-4, 1996 Apr.
Artigo em Japonês | MEDLINE | ID: mdl-8666882

RESUMO

A 65-year-old man complained chest oppression at rest and dizziness. Echocardiography showed subaortic stenosis with outflow gradient of 100 mmHg, although interventricular septal thickness was only 12 mm and left ventricular posterior wall thickness was 11 mm, and mild mitral regurgitation. Selective coronary angiography demonstrated 90% stenosis in left main truncus, 50% stenosis in first diagonal branch, and hypoplastic right coronary artery. Emergent coronary artery revasculization concomitant with left ventricular myotomy myectomy was performed. Immediately after weaning off the cardiopulmonary pump, IABP was employed for cardiac assistance, because of residual left ventricular outflow pressure gradient, which was provoked by cathecholamine and amyl nitrite. He was discharged in 1 month in NYHA class I. Echocardiography 3 months after operation showed no residual outflow pressure gradient, no systolic anterior motion of mitral anterior leaflet, and mild approximately mitral regurgitation. Careful operative management, including myocardial protection and avoiding perforation of ventricular septum and postoperative medical care are mandatory to this group of patients. This case is the first successful coronary artery bypass grafting and concomitant left ventricular myotomy-myectomy reported in Japan.


Assuntos
Cardiomiopatia Hipertrófica/complicações , Ponte de Artéria Coronária , Doença das Coronárias/cirurgia , Idoso , Angina Instável/complicações , Angina Instável/cirurgia , Procedimentos Cirúrgicos Cardíacos/métodos , Doença das Coronárias/complicações , Ventrículos do Coração/cirurgia , Humanos , Masculino
4.
J Dermatol ; 16(4): 321-4, 1989 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-2600269

RESUMO

A 26-year-old woman developed 249 discrete papules on her lower extremities. Twenty-three of them had keratotic plugs. Histologic examination demonstrated granulomatous foci consisting of epithelioid cells and a epidermal invagination which was disrupted at the base and lateral sites. This invagination was considered to represent transepithelial elimination.


Assuntos
Ceratose/patologia , Sarcoidose/patologia , Dermatopatias/patologia , Adulto , Feminino , Humanos
5.
Rinsho Hoshasen ; 34(2): 261-4, 1989 Feb.
Artigo em Japonês | MEDLINE | ID: mdl-2666689

RESUMO

A patient with post-operative recurrent parathyroid adenoma was treated with percutaneous injection of absolute ethanol under ultrasonographic guidance. Serum calcium and PTH level were both successfully normalized, while recurrent nerve palsy was encountered as side effect. Six months later, she was suffered from hyperparathyroidism again, because of local tumor recurrence. Her recurrent nerve palsy was cured at that time. This technic could be a simple and non-invasive alternative for the conventional surgical procedure, but the indication for larger adenomas like this case should be carefully considered.


Assuntos
Adenoma/terapia , Hipofisectomia Química , Hipofisectomia , Neoplasias das Paratireoides/terapia , Adulto , Feminino , Humanos , Recidiva Local de Neoplasia/terapia , Ultrassonografia
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