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1.
Mar Drugs ; 22(2)2024 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-38393029

RESUMO

Five new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes J-N (1-5), along with three known analogues (6-8), were obtained from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y85. The chemical structures, including their absolute configurations, were established via spectroscopic data and comparison of experimental and calculated ECD spectra. Cytotoxicity assay results indicated that compound 8 had strong cytotoxicity against HeLa cancer cells, and its IC50 value was 11.8 µM. In addition, flow cytometry analysis revealed that the cytotoxicity of 8 was due to the induction of G1 cell cycle arrest and apoptosis in HeLa cells.


Assuntos
Antineoplásicos , Aspergillus , Humanos , Estrutura Molecular , Células HeLa , Aspergillus/química , Análise Espectral , Antineoplásicos/farmacologia , Antineoplásicos/metabolismo
2.
Phytochemistry ; 218: 113955, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38128773

RESUMO

Nine previously undescribed diisoprenyl-cyclohexene-type meroterpenoids, aspergienynes A-I, together with five known analogues, were obtained from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y65. The diisoprenyl-cyclohexene-type meroterpenoids were elucidated based on multispectroscopic analysis, and the previously undescribed compounds' absolute configurations were established via electronic circular dichroism calculations. Biological activity results indicated that aspergienyne C (compound 3) had strong anti-nonalcoholic steatohepatitis activity against AML12 cells treated with PA (Palmitic acid) + OA (Oleic acid). At the same concentration of 20 µM, 3 significantly reduced triglyceride (TG) content compared with fenofibrate (positive control) in PA + OA treated AML12 cells, and obviously increased phosphorylation of acetyl-CoA carboxylase.


Assuntos
Aspergillus , Fígado Gorduroso , Aspergillus/química , Dicroísmo Circular , Estrutura Molecular
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