RESUMO
Background: Complex proximal interphalangeal joint (PIPJ) fractures are challenging injuries to treat. There are multiple established treatment methods available for these injuries, including dynamic external fixation. This study reports the outcomes of complex PIPJ fractures treated with a hand-specific external fixation device. Methods: Twenty-five fingers in 25 patients were treated with the DigiFix external fixator device for treatment of a PIPJ dorsal fracture dislocation (n = 16) or pilon fracture (n = 9). There were 16 males and 9 females with a mean age of 40 years (range: 14-75 years) at the time of injury. The median time from injury to surgery was 10 days (interquartile range [IQR]: 5; range: 3-49). Chart and radiographic data were reviewed retrospectively. Results: The average duration of external fixation was 41 days (range: 26-62 days). At a mean follow-up of 28 weeks (range: 12-105 weeks), the mean PIPJ flexion was 82 (range: 30-105 degrees), extension was -10° (range: -30 to 0 degrees), and flexion/extension arc of motion was 72 degrees (range: 30-95 degrees). Final mean Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score was 21.5 (range: 0-65.8). There were zero major complications and six (24%) minor complications, including superficial cellulitis (4) and stiffness (2). Conclusion: Dynamic external fixation for the treatment of complex PIPJ injuries allows for early range of motion and leads to favorable outcomes. This hand-specific external fixator has a reproducible technique which results in predictable and reliable PIPJ distraction.
RESUMO
Dupuytren disease and its associated digit contracture often negatively impact the quality of life for patients. Severe cases of Dupuytren contracture and symptom recurrence are both difficult for hand surgeons to treat. Improved treatment options are therefore needed. One method is continuous passive elongation (CPE). In CPE, a device is affixed to the digit, which applies a continuous extending force to pull the affected finger out of flexion. Multiple external fixators used to induce CPE have been reported. However, a low-profile, hand-specific external fixator, the DigiFix, provides benefits over previously reported devices. We present the technique of CPE using DigiFix as a beneficial and versatile adjunct treatment for severe and recurrent cases of Dupuytren contracture.
Assuntos
Contratura de Dupuytren , Humanos , Contratura de Dupuytren/cirurgia , Qualidade de Vida , Recidiva Local de Neoplasia , Dedos , Fixadores Externos , Resultado do TratamentoRESUMO
The most common cause for catching or snapping in the finger is stenosing tenosynovitis, that is, trigger finger. Although less common, snapping can also occur as a result of extensor mechanism injury. Among these injuries, sagittal band rupture is most common and leads to snapping at the metacarpophalangeal joint. Snapping at the proximal interphalangeal (PIP) joint is rare with only 4 reported cases; reported mechanisms of PIP joint snapping include retinacular ligament injury or tendon impingement. We present a unique case of painful finger snapping at the PIP joint as a result of longitudinal tear of the central slip, leading to sudden subluxation of one-half of the central slip and conjoint lateral band with flexion of the PIP joint.
Assuntos
Traumatismos dos Dedos , Luxações Articulares , Lacerações , Humanos , Dedos/cirurgia , Traumatismos dos Dedos/complicações , Traumatismos dos Dedos/cirurgia , TendõesRESUMO
Diagnosing ulnar-sided carpometacarpal joint dislocation is difficult, and more than half of injuries are missed on initial examination. The authors hypothesized that measuring the angle between the capitate and the metacarpals (capitate-metacarpal angle) on a plain radiograph would provide a simple, reliable tool to aid in the diagnosis of ulnar-sided carpometacarpal dislocation. This study retrospectively reviewed patients who underwent surgery for ulnar-sided carpometacarpal dislocation (study group). Two authors identified the contour of the capitate and the second, fourth, and fifth metacarpals on plain radiographs. The control group consisted of patients who had radiographs and no bony carpal or metacarpal pathology. Information on the contour of each bone was entered into MATLAB, version 8.5, software (MathWorks, Natick, Massachusetts), which calculated the 2-dimensional angles. A 3-dimensional model based on computed tomography scan data was used to obtain a "true lateral" image to account for variable rotation on plain radiographs. With the use of conventional lateral hand radiographs, the average capitate-metacarpal angle in the control group was 10° compared with 19° in the study group. Using a screening value of 15° on plain radiographs, the sensitivity of the capitate-metacarpal angle was 0.85 and the specificity was 0.79. Both 2-dimensional and 3-dimensional measurements showed that the angle between the capitate and the lesser metacarpals is a reliable screening tool for carpometacarpal dislocation. During evaluation of patients with posttraumatic hand pain, an increased capitate-metacarpal angle may indicate the need for advanced imaging studies to further evaluate the carpometacarpal joints. [Orthopedics. 2017; 40(2):e352-e356.].
Assuntos
Capitato/diagnóstico por imagem , Articulações Carpometacarpais/lesões , Luxações Articulares/diagnóstico por imagem , Ossos Metacarpais/diagnóstico por imagem , Articulações Carpometacarpais/diagnóstico por imagem , Estudos de Casos e Controles , Humanos , Imageamento Tridimensional , Radiografia , Estudos Retrospectivos , Sensibilidade e Especificidade , Tomografia Computadorizada por Raios XRESUMO
Metacarpophalangeal (MP) joint contractures are common after traumatic injury, and can be difficult to manage. After surgical capsulectomy, it remains challenging to maintain motion that was obtained at the time of surgery. Our group uses a novel, prefabricated digital external fixator to provide both distraction, and motion therapy across the MP joint after surgical treatment of MP contracture. The purpose of this technique is to demonstrate the effectiveness of an adjunctive dynamic distraction external fixator for the maintenance of joint motion after surgical treatment of MP contractures of the border digits.
Assuntos
Contratura/cirurgia , Traumatismos dos Dedos/cirurgia , Fixação de Fratura/instrumentação , Articulação Metacarpofalângica/cirurgia , Osteogênese por Distração/métodos , Amplitude de Movimento Articular/fisiologia , Adulto , Contratura/diagnóstico , Fixadores Externos , Feminino , Traumatismos dos Dedos/diagnóstico , Fixação de Fratura/métodos , Consolidação da Fratura/fisiologia , Força da Mão/fisiologia , Humanos , Articulação Metacarpofalângica/lesões , Pessoa de Meia-Idade , Osteogênese por Distração/reabilitação , Medição de Risco , Estudos de AmostragemRESUMO
PURPOSE: To evaluate the outcomes of patients who underwent application of hinged external fixators for chronic elbow fracture-dislocations. We hypothesized that patients treated for this injury pattern can achieve satisfactory outcomes but encounter many complications and require numerous additional procedures. METHODS: We performed a retrospective review of 7 patients who were surgically treated with application of a hinged external fixator for chronic ulnohumeral elbow fracture-dislocation. Patients were included only if they had complete ulnohumeral dislocation of greater than 1 month's duration. Demographics, injury pattern, and range of motion were documented. Preoperative and postoperative range of motion was recorded and any treatment complications or additional surgeries were noted. RESULTS: The interval between the initial injury and index procedure averaged 8 months. All patients underwent initial treatment with open reduction internal fixation. Average arc of ulnohumeral motion improved from 26° (range, 0° to 60°) to 120° (range, 100° to 145°). Overall, 4 of 7 patients developed at least one complication during treatment. Three patients required additional procedures aside from removal of the hinged external fixator. These 3 patients underwent a total of 13 additional procedures. CONCLUSIONS: Although patients can achieve good outcomes, realistic expectations should be set. Patients should be aware that surgery can be associated with a high risk of complications, potential treatment failure, and a need for additional surgical procedures. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.
Assuntos
Lesões no Cotovelo , Fraturas Ósseas/cirurgia , Luxações Articulares/cirurgia , Adolescente , Adulto , Doença Crônica , Articulação do Cotovelo/fisiopatologia , Fixadores Externos , Feminino , Fraturas Ósseas/fisiopatologia , Humanos , Luxações Articulares/fisiopatologia , Masculino , Pessoa de Meia-Idade , Amplitude de Movimento Articular , Estudos Retrospectivos , Resultado do TratamentoRESUMO
PURPOSE: To characterize patients with hand or wrist injuries presenting to our university-based emergency department (ED) after a previous evaluation by an outside ED. We hypothesized that a majority of these patients did not require emergent care, most arrived during working hours, and a disproportionate number were uninsured. METHODS: We retrospectively reviewed 3,047 orthopedic hand consults from 2002 to 2010. Patients were included if our ED was the patient's second ED evaluation within 30 days for the same complaint. Demographics, diagnosis, referral instructions from the initial institution, date and time of ED visit, treatment received, and insurance status were recorded. Clinical urgency was quantified on an ordinal scale. RESULTS: A total of 325 patients met the inclusion criteria. The most common diagnoses were distal radius and metacarpal fractures. There were 266 (82%) patients with nonurgent diagnoses. A junior-level orthopedic resident treated and discharged 97% of patients from the ED. Sixty-two percent of the patients were uninsured, 32% had Medicaid, and 6% had commercial insurance or Medicare. There was a disproportionate percentage of uninsured and Medicaid patients compared with the payer mix of our state, orthopedic department, and ED. Ninety percent of patients presented on weekdays, and 84% arrived between 6 am and 6 pm. CONCLUSIONS: Most patients who met our inclusion criteria presented to our ED during regular business hours. Most were uninsured and did not have a condition that warranted urgent or emergent evaluation and treatment. With limited resources, it is important that an appropriate follow-up plan from the initial ED be in place so that patients do not have to present to a second ED for the same problem. TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic IV.
Assuntos
Serviço Hospitalar de Emergência/estatística & dados numéricos , Fraturas Ósseas/cirurgia , Traumatismos da Mão/cirurgia , Ossos Metacarpais/lesões , Fraturas do Rádio/cirurgia , Traumatismos do Punho/cirurgia , Traumatismos dos Dedos/cirurgia , Humanos , Medicaid , Pessoas sem Cobertura de Seguro de Saúde/estatística & dados numéricos , Estudos Retrospectivos , Estados UnidosRESUMO
Symptomatic Kienbock disease with ulnar-negative variance is commonly treated with a distal radius shortening osteotomy. Traditionally, the osteotomy is stabilized using dorsal or volar plating. Use of an intramedullary implant to stabilize the osteotomy in the treatment of this condition is demonstrated in this article. In addition to changing the mechanical loading through the lunate, the technique also allows for core decompression the distal radial metaphyseal bone that may further help in restoring the vascularity to the lunate. The authors believe that this technique is a valuable method that demonstrates both clinical and technical improvements in the treatment of Kienbock disease.
Assuntos
Placas Ósseas , Osteonecrose/cirurgia , Osteotomia/métodos , Rádio (Anatomia)/cirurgia , Amplitude de Movimento Articular/fisiologia , Articulação do Punho/cirurgia , Adulto , Feminino , Seguimentos , Fixação Intramedular de Fraturas/instrumentação , Fixação Intramedular de Fraturas/métodos , Humanos , Fixadores Internos , Masculino , Pessoa de Meia-Idade , Osteonecrose/diagnóstico por imagem , Osteotomia/instrumentação , Medição da Dor , Radiografia , Rádio (Anatomia)/diagnóstico por imagem , Rádio (Anatomia)/fisiopatologia , Recuperação de Função Fisiológica , Medição de Risco , Estudos de Amostragem , Resultado do Tratamento , Articulação do Punho/diagnóstico por imagem , Articulação do Punho/fisiopatologiaAssuntos
Plexo Braquial/anormalidades , Síndrome de Esmagamento/cirurgia , Fraturas do Úmero/cirurgia , Amplitude de Movimento Articular/fisiologia , Luxação do Ombro/cirurgia , Traumatismos do Braço/diagnóstico por imagem , Traumatismos do Braço/cirurgia , Axila/inervação , Plexo Braquial/cirurgia , Terapia Combinada/métodos , Síndrome de Esmagamento/diagnóstico , Fixação Interna de Fraturas/métodos , Humanos , Fraturas do Úmero/diagnóstico por imagem , Escala de Gravidade do Ferimento , Masculino , Pessoa de Meia-Idade , Traumatismo Múltiplo/diagnóstico , Traumatismo Múltiplo/cirurgia , Procedimentos Ortopédicos/métodos , Radiografia , Doenças Raras , Recuperação de Função Fisiológica , Medição de Risco , Luxação do Ombro/diagnóstico por imagem , Resultado do TratamentoRESUMO
BACKGROUND: Ethyl chloride topical anesthetic spray is labeled as nonsterile, yet it is widely used during injection procedures performed in an outpatient setting. The purpose of this study was to investigate the sterility of ethyl chloride topical anesthetic spray applied before an injection. Our a priori hypothesis was that application of the spray after the skin has been prepared would not alter the sterility of the injection site. METHODS: We conducted a prospective, blinded, controlled study to assess the effect of ethyl chloride spray on skin sterility. Fifteen healthy adult subjects (age, twenty-three to sixty-one years) were prepared for mock injections into both shoulders and both knees, although no injection was actually performed. Three culture samples were obtained from each site on the skin: one before skin preparation with isopropyl alcohol, one after skin preparation and before application of ethyl chloride, and one after ethyl chloride had been sprayed on the site. In addition, the sterility of the ethyl chloride was tested directly by inoculating cultures with spray from the bottles. RESULTS: Growth occurred in 70% of the samples obtained before skin preparation, 3% of the samples obtained after skin preparation but before application of ethyl chloride, and 5% of the samples obtained after the injection site had been sprayed with ethyl chloride. The percentage of positive cultures did not increase significantly after application of ethyl chloride (p = 0.65). Spraying of ethyl chloride directly on agar plates resulted in growth on 13% of these plates compared with 11% of the control plates; this difference was also not significant (p = 0.80). CONCLUSIONS: Although ethyl chloride spray is not sterile, its application did not alter the sterility of the injection sites in the shoulder and knee.
Assuntos
Anestésicos Locais/administração & dosagem , Cloreto de Etil/administração & dosagem , Pele/microbiologia , Adulto , Humanos , Injeções Intra-Articulares , Joelho , Pessoa de Meia-Idade , Estudos Prospectivos , Ombro , Método Simples-Cego , Esterilização/métodos , Adulto JovemRESUMO
PURPOSE: Intramedullary fixation is one treatment option for distal radius fractures. Our purpose was to compare the outcomes of intramedullary nailing to those of casting for these injuries. METHODS: From 2006 to 2009, we reviewed 63 adult patients with isolated distal radius fractures. Thirty-one patients had surgical fixation with an intramedullary device (IMN group) within 4 weeks of the injury, and 32 (cast group) had casting as definitive treatment of the fracture. Clinical outcomes (grip strength; Disabilities of the Arm, Shoulder, and Hand scores; active wrist range of motion; and complications) and radiographic indices (radial inclination, radial height, ulnar variance, and tilt) of both groups were analyzed for the 1-, 2-, 4-, 6-, and 12-month follow-up periods. RESULTS: The flexion-extension arc was significantly higher in the IMN group than in the cast group at 2-, 6-, and 12-month follow-up. The IMN group exhibited significantly greater grip strength and lower DASH scores throughout the follow-up period. At final follow-up, all radiographic indices were significantly better in the IMN group than in the cast group. There was no significant difference between the initial reduction to final position in the IMN group, but the cast group showed an increase in ulnar variance and a significant change in dorsal-volar tilt. In addition, the cast group experienced more clinical complications in the delayed period compared to the IMN group. CONCLUSIONS: Intramedullary nail fixation, as compared to casting, results in less functional disability, not only in the early postoperative period but also up to a year after treatment. On the basis of our data, intramedullary fixation should be considered for patients with unstable extra-articular or simple intra-articular distal radius fractures.
Assuntos
Moldes Cirúrgicos , Fixação Intramedular de Fraturas , Fixação de Fratura , Fraturas do Rádio/cirurgia , Traumatismos do Punho/cirurgia , Articulação do Punho/cirurgia , Idoso , Idoso de 80 Anos ou mais , Avaliação da Deficiência , Feminino , Fixação Interna de Fraturas , Força da Mão , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Fraturas do Rádio/diagnóstico por imagem , Traumatismos do Punho/diagnóstico por imagem , Articulação do Punho/diagnóstico por imagemAssuntos
Luxações Articulares/diagnóstico , Luxações Articulares/cirurgia , Articulação Esternoclavicular/lesões , Articulação Esternoclavicular/cirurgia , Acidente Vascular Cerebral/diagnóstico , Adulto , Clavícula/cirurgia , Futebol Americano/lesões , Humanos , Angiografia por Ressonância Magnética , Masculino , Artéria Cerebral Média/patologia , Dor de Ombro/etiologia , Articulação Esternoclavicular/diagnóstico por imagem , Tendões/transplante , Tomografia Computadorizada por Raios X , Adulto JovemRESUMO
PURPOSE: Several recent studies showed an increase in methicillin-resistant Staphylococcus aureus (MRSA) hand infections. The purpose of this study was to determine the prevalence of community-acquired MRSA hand infections in an urban setting and to determine independent risk factors for such infections. METHODS: A retrospective chart review of patients with hand infections was performed from 2002 to 2009. Those with community-acquired hand infections who had surgical irrigation and debridement and intraoperative culture were entered into the study. Patient demographics-including age and gender; mechanism of injury; infection risk factors (diabetes, chronic hepatitis, intravenous intravenousdrug use, and immune-compromised conditions); place of residence/housing status; history of hospitalization, prior antibiotics use and surgery; and culture results, erythrocyte sedimentation rate, C-reactive protein, and white blood cell count-were extracted from the medical records. Regression analyses were performed to identify significant risk factors for MRSA infection. RESULTS: A total of 102 patients met our inclusion criteria. The MRSA organism was identified in 32 patients. In the analysis of all the potential risk factors, only intravenous drug use showed significant correlation with MRSA infection. CONCLUSIONS: In our patients, only intravenous drug use correlated with community-acquired MRSA hand infections. Patient education about intravenous drug use and empiric treatment with MRSA-appropriate antibiotics for intravenous drug users presenting with hand infections are recommended. TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic IV.
Assuntos
Infecções Comunitárias Adquiridas/epidemiologia , Mãos/microbiologia , Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos , Infecções Estafilocócicas/epidemiologia , Abuso de Substâncias por Via Intravenosa/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Distribuição de Qui-Quadrado , Pré-Escolar , Infecções Comunitárias Adquiridas/tratamento farmacológico , Infecções Comunitárias Adquiridas/microbiologia , Diabetes Mellitus/epidemiologia , Feminino , Hepatite/epidemiologia , Humanos , Hospedeiro Imunocomprometido , Incidência , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Análise de Regressão , Estudos Retrospectivos , Fatores de Risco , Distribuição por Sexo , Infecções Estafilocócicas/tratamento farmacológico , Estados Unidos/epidemiologia , População Urbana , Adulto JovemRESUMO
PURPOSE: Besides its anti-inflammatory effects, nonsteroidal anti-inflammatory drug therapy may affect tendon healing and the development of peritendinous adhesions. The purpose of this study was to compare the effect of nonselective (ibuprofen) and COX-2 selective (rofecoxib) nonsteroidal anti-inflammatory drugs on the adhesion formation after tendon repair. METHODS: We assigned 67 rabbits to one of 3 (placebo, ibuprofen, or rofecoxib) groups. The deep flexor tendon was transected, followed by a primary repair. Dosing of the medication began the day after surgery and continued for 27 days. The animals were immobilized in a cast for the first 14 days. Postoperatively, tendon adhesion formation was assessed histologically by calculating the total adhesion in serial axial tendon sections at 3 and 6 weeks and by range of motion measurements at 6 and 12 weeks. We measured range of motion by fixing the metacarpal, applying increasing weight to the free end of the flexor digitorum profundus, and measuring the flexion angle between the metacarpal and the proximal phalanx. Comparison was performed between the treatment groups, as well as to the unoperated forepaws. RESULTS: Based on histology, we found no difference between the treatment groups when determining the percentage of adhesion between the flexor tendon and its sheath. Control unoperated forepaws had a significantly greater range of metacarpophalangeal joint flexion than the surgically repaired groups. At 12 weeks, range of motion in the ibuprofen group was significantly better than the placebo (p=.009) and rofecoxib (p=.009) groups. CONCLUSIONS: Ibuprofen has a more important effect in limiting adhesion formation compared with rofecoxib after flexor tendon repair. Because ibuprofen inhibits both COX-1 and COX-2, whereas rofecoxib only inhibits COX-2, ibuprofen therapy appears to offer a greater beneficial effect on tendon repair by reducing formation of adhesions.
Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Inibidores de Ciclo-Oxigenase 2/farmacologia , Ibuprofeno/farmacologia , Lactonas/farmacologia , Sulfonas/farmacologia , Tendões/cirurgia , Cicatrização/efeitos dos fármacos , Animais , Membro Anterior , Masculino , Coelhos , Aderências Teciduais/prevenção & controleRESUMO
PURPOSE: Malunited distal radius fractures pose considerable problems, especially for young, active individuals. Surgical correction with osteotomy, bone grafting, and internal fixation with plates and screws has been the treatment of choice. Locked intramedullary fixation is an alternative technique to provide bony stability while minimizing soft tissue irritation in the management of acute distal radius fractures, with acceptable clinical results. The purpose of this study was to describe our experience with the use of an intramedullary device combined with grafting to repair distal radial malunions. This fixation device is inserted through the radial styloid and obtains distal fixation with 3 fixed-angle locking screws. METHODS: Thirteen patients underwent distal radius malunion repair with an intramedullary implant and grafting. There were 6 male and 7 female participants with an average age of 51 years (range, 18-72 y). Patients were evaluated at an average follow-up of 24 months (range, 13-38 mo). Clinical outcome was measured by range of motion of the wrist and forearm, and grip strength, and by using the Disabilities of the Arm, Shoulder, and Hand questionnaire. We analyzed radiographs to determine time to union and adequacy of correction. RESULTS: All of the malunions healed, with an average time to healing of 11 weeks. Patients' average range of motion at follow-up was 56 degrees of flexion, 66 degrees extension, 85 degrees pronation, and 84 degrees supination. Mean grip strength was 83% of the unaffected side, and the average Disabilities of the Arm, Shoulder, and Hand score was 21. Radiographs taken on the latest follow-up showed correction to the following average parameters: 20.6 degrees radial inclination, 11.0 mm radial height, +1.0 mm ulnar variance, and 2.1 degrees volar tilt. CONCLUSIONS: The technique presented in this report demonstrates the effectiveness of an intramedullary nail combined with bone graft or graft substitute in repairing malunited fractures of the distal radius. The results show reliable correction of the deformity and good functional outcomes. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.
Assuntos
Fixação Intramedular de Fraturas/métodos , Fraturas Mal-Unidas/cirurgia , Fraturas do Rádio/cirurgia , Adolescente , Adulto , Idoso , Transplante Ósseo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Amplitude de Movimento Articular , Resultado do Tratamento , Articulação do Punho/fisiopatologia , Adulto JovemRESUMO
BACKGROUND AND PURPOSE: Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity, which is the rate-limiting enzyme in the synthesis of prostaglandins. Previous studies have indicated that NSAID therapy, and in particular NSAIDs that specifically target the inflammatory cyclooxygenase (COX-2), impair bone healing. We compared the effects of ibuprofen and rofecoxib on fibula osteotomy healing in rabbits to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-life in vivo. METHODS: Bilateral fibula osteotomies were done in 67 skeletally mature male New Zealand white rabbits. The rabbits were treated with placebo, rofecoxib (12.5 mg once a day), or ibuprofen (50 mg 3 times a day) for 28 days after surgery. Plasma ibuprofen levels were measured by HPLC analysis. Bone healing was assessed by histomorphometry at 3 and 6 weeks after osteotomy, and at 6 and 12 weeks by torsional mechanical testing. RESULTS: Plasma ibuprofen levels peaked and declined between successive doses. Fracture callus morphology was abnormal in the rofecoxib-treated rabbits and torsional mechanical testing showed that fracture healing was impaired. Ibuprofen treatment caused persistence of cartilage within the fracture callus and reduced peak torque at 6 weeks after osteotomy as compared to the fibulas from the placebo-treated rabbits. In the specimens allowed to progress to possible healing, non-union was seen in 5 of the 26 fibulas from the rofecoxib-treated animals as compared to 1 of 24 in the placebo group and 1 of 30 in the ibuprofen treatment group. INTERPRETATION: Continuous COX-2 inhibition as modeled by rofecoxib treatment appears to be more deleterious to fracture repair than cyclical cyclooxygenase inhibition as modeled by ibuprofen treatment. Ibuprofen treatment appeared to delay bone healing based upon the persistence of cartilage within the fracture callus and diminished shear modulus. Despite the ibuprofen-induced delay, rofecoxib treatment produced worse fracture (osteotomy) healing than ibuprofen treatment.
Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Inibidores de Ciclo-Oxigenase 2/farmacologia , Fíbula/cirurgia , Consolidação da Fratura/efeitos dos fármacos , Fraturas Ósseas/cirurgia , Ibuprofeno/farmacologia , Lactonas/farmacologia , Osteotomia , Sulfonas/farmacologia , Analgésicos não Narcóticos/administração & dosagem , Analgésicos não Narcóticos/sangue , Analgésicos não Narcóticos/farmacologia , Animais , Anti-Inflamatórios não Esteroides/efeitos adversos , Anti-Inflamatórios não Esteroides/sangue , Fenômenos Biomecânicos , Inibidores de Ciclo-Oxigenase 2/administração & dosagem , Inibidores de Ciclo-Oxigenase 2/sangue , Fíbula/efeitos dos fármacos , Fíbula/patologia , Fraturas Ósseas/tratamento farmacológico , Ibuprofeno/administração & dosagem , Ibuprofeno/sangue , Lactonas/administração & dosagem , Lactonas/sangue , Masculino , Coelhos , Sulfonas/administração & dosagem , Sulfonas/sangueRESUMO
The Artelon CMC spacer (Small Bone Innovations, Inc., Morrisville, PA) is a relatively new device that was developed for the treatment of basal joint arthritis. It is composed of a biodegradable polycaprolactone-based polyurethane urea that acts to resurface the distal part of the trapezium and stabilize the trapeziometacarpal joint by augmenting the joint capsule. This is a case report of a foreign-body tissue reaction to the Artelon CMC spacer.
Assuntos
Implantes Absorvíveis/efeitos adversos , Reação a Corpo Estranho/etiologia , Prótese Articular/efeitos adversos , Sinovite/etiologia , Articulações Carpometacarpais/fisiopatologia , Articulações Carpometacarpais/cirurgia , Doença Crônica , Feminino , Humanos , Cápsula Articular/cirurgia , Pessoa de Meia-Idade , Osteoartrite/fisiopatologia , Osteoartrite/cirurgia , Poliésteres/efeitos adversos , Poliuretanos/efeitos adversos , Trapézio/cirurgiaRESUMO
PURPOSE: The purpose of this study is to quantify finger/digit rotation, overlap, parallelism, and convergence to the scaphoid tuberosity in normal volunteers to establish standards for comparison. METHODS: We examined 240 uninjured fingers in 30 volunteers. There were 14 men and 16 women with an average age of 35 years. Rotation was determined with the palm flat and fingers extended. Digit overlap, parallelism (angular relationship between the index, ring, and small fingers with respect to the middle finger) and scaphoid convergence were determined with simultaneous flexion of metacarpophalangeal and proximal interphalangeal joints. Linear and angular measurements were performed with imaging software. RESULTS: Rotation, parallelism, and scaphoid convergence measurements were similar comparing left with right hands. Rotation: All digits were found to be in supination relative to the horizontal plane; the small fingers averaged 9 degrees, the ring fingers 4 degrees, the middle fingers 8 degrees, and the index fingers 12 degrees. Parallelism: Angular measurements between the middle finger and the small finger averaged 19 degrees, between the middle finger and the ring finger 9 degrees, and between the middle finger and the index finger 11 degrees. Scaphoid convergence: In no hand did all 4 fingers converge onto scaphoid tuberosity. Whereas small and ring finger trajectories averaged -0.1 to 1.2 mm from the scaphoid tubercle, the middle finger averaged 4.0 to 4.6 mm and the index finger 8.1 to 9.5 mm. Overlap: Ninety percent of individuals demonstrated digit overlap, although none covered more than 50% of the adjacent nail plate. Seventy-seven percent of these were bilateral, and 73% were asymmetric. CONCLUSIONS: This study establishes the normal parameters for digit rotation, overlap, parallelism, and scaphoid convergence. For digit rotation, parallelism, and scaphoid convergence, the contralateral (uninjured) hand can be used reliably for comparison. However, for digit overlap, the contralateral hand should not be used for comparison because of side-to-side asymmetry and variability. TYPE OF STUDY/LEVEL OF EVIDENCE: Diagnostic IV.