Assuntos
Xantogranuloma Juvenil/diagnóstico por imagem , Criança , Feminino , Humanos , UltrassonografiaAssuntos
Dermatoses Faciais/diagnóstico , Fasciite/diagnóstico , Criança , Diagnóstico Diferencial , Cisto Epidérmico/diagnóstico , Sobrancelhas , Dermatoses Faciais/diagnóstico por imagem , Dermatoses Faciais/patologia , Neoplasias Faciais/diagnóstico , Fasciite/diagnóstico por imagem , Fasciite/patologia , Feminino , Fibroblastos/patologia , Humanos , Miofibroblastos/patologia , Tela SubcutâneaAssuntos
Histiocitoma Fibroso Benigno/diagnóstico por imagem , Neoplasias Cutâneas/diagnóstico por imagem , Ultrassonografia Doppler , Abdome , Adulto , Braço , Carcinoma de Células Escamosas , Feminino , Histiocitoma Fibroso Benigno/irrigação sanguínea , Humanos , Masculino , Pessoa de Meia-Idade , Segunda Neoplasia Primária/diagnóstico por imagem , Neoplasias Faríngeas , Neoplasias Cutâneas/irrigação sanguíneaAssuntos
Insuficiência Adrenal/complicações , Calcinose/etiologia , Cartilagem da Orelha/patologia , Insuficiência Adrenal/sangue , Insuficiência Adrenal/diagnóstico , Hormônio Adrenocorticotrópico/sangue , Calcinose/diagnóstico por imagem , Cartilagem da Orelha/diagnóstico por imagem , Humanos , Hidrocortisona/sangue , Hidrocortisona/metabolismo , Hiponatremia/etiologia , Masculino , Pessoa de Meia-IdadeRESUMO
BACKGROUND: Leishmaniasis, an endemic infection in Spain, is caused by protozoan parasites of the Leishmania genus. Between 2010 and 2012, there was an outbreak of cutaneous and visceral leishmaniasis in Fuenlabrada, Madrid. OBJECTIVES: To describe the cases of cutaneous leishmaniasis diagnosed over a 17-month period at the dermatology department of Hospital de Fuenlabrada. MATERIAL AND METHODS: We analyzed the epidemiological, clinical, histological, and microbiological features of each case and also evaluated the treatments administered and outcomes. RESULTS: We studied 149 cases. The incidence of cutaneous leishmaniasis showed a peak in the age range between 46 and 60 years and was similar in men and women. At the time of consultation, the lesions had been present for between 2 and 6 months in the majority of patients. The most common clinical presentation was with erythematous plaques and papules without crusts (52% of cases). Lesions were most often located in sun-exposed areas and were multiple in 57% of patients. In 67% of cases, the histological study showed non-necrotizing granulomatous dermatitis with no evidence of parasites using conventional staining methods. Diagnosis was confirmed by polymerase chain reaction (PCR) in 98% of patients. In the remaining cases, the histological study revealed Leishman-Donovan bodies in the skin. Intralesional pentavalent antimonials were the most commonly used drugs (76% of cases) and produced satisfactory results. CONCLUSIONS: We have presented a large series of cases of cutaneous leishmaniasis diagnosed in the context of an outbreak. Multiple papules were the most common clinical presentation, with histology that showed non-necrotizing granulomatous dermatitis with no evidence of parasites. PCR of skin samples was the test that most frequently provided the diagnosis.
Assuntos
Surtos de Doenças , Leishmaniose Cutânea/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Espanha/epidemiologia , Saúde da População Urbana , Adulto JovemRESUMO
Eosinophilic polymorphic and pruritic eruption associated with radiotherapy (EPPER) is a rare entity that appears in oncological patients after radiotherapy. We describe two patients with breast tumour who presented with EPPER in a different area from the one that had been irradiated. One of them needed different types of treatment, topical and systemic corticosteroids, antihistamines and narrowband ultraviolet B. The other one responded to the application of topical corticosteroids. We suggested that this eruption could be more frequent than has been reported.
Assuntos
Neoplasias da Mama/radioterapia , Eosinofilia/etiologia , Prurido/etiologia , Radiodermite/patologia , Terapia Combinada , Eosinofilia/terapia , Feminino , Humanos , Pessoa de Meia-Idade , Prurido/terapia , Radiodermite/terapiaAssuntos
Angiomiolipoma/patologia , Neoplasias Nasais/patologia , Actinas/biossíntese , Angiomiolipoma/metabolismo , Desmina/biossíntese , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Músculo Liso/metabolismo , Músculo Liso/patologia , Cavidade Nasal/metabolismo , Cavidade Nasal/patologia , Neoplasias Nasais/metabolismoAssuntos
Carcinoma Papilar/patologia , Carcinoma de Células de Transição/patologia , Neoplasias Vaginais/patologia , Idoso , Carcinoma Papilar/metabolismo , Carcinoma de Células Escamosas/patologia , Carcinoma de Células de Transição/metabolismo , Diferenciação Celular , Diagnóstico Diferencial , Feminino , Humanos , Imuno-Histoquímica , Queratina-7 , Queratinas/análise , Neoplasias Vaginais/metabolismoRESUMO
Undifferentiated nasopharyngeal carcinomas are universally associated with Epstein-Barr virus (EBV). This association has been exclusively established in lymphoepithelioma-like carcinomas in some locations. The relationship between EBV and lymphoepithelioma-like carcinomas in the larynx is unknown. In none of the few laryngeal lymphoepithelioma-like carcinomas reported have EBV investigations been carried out. We present here two supraglottic laryngeal lymphoepithelioma-like carcinomas in which EBV antigens were not demonstrable using immunohistochemical and molecular methods. Our results suggest that EBV may not be involved in laryngeal lymphoepithelioma-like carcinoma at least in Western patients.