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1.
Chembiochem ; 24(15): e202300186, 2023 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-37069129

RESUMO

Minimally invasive boron neutron capture therapy (BNCT) is an elegant approach for cancer treatment. The highly selective and efficient deliverability of boron agents to cancer cells is the key to maximizing the therapeutic benefits of BNCT. In addition, enhancement of the frequencies to achieve boron neutron capture reaction is also significant in improving therapeutic efficacy by providing a highly concentrated boron agent in each boron nanoparticle. As the density of the thermal neutron beam remains low, it is unable to induce high-efficiency cell destruction. Herein, we report phospholipid-coated boronic oxide nanoparticles as agents for BNCT that can provide a highly concentrated boron atom in each nanoparticle. The current system exhibited in vitro BNCT activity seven times higher than that of commercial boron agents. Furthermore, the system could penetrate cancer spheroids deeply, efficiently suppressing thermal neutron irradiation-induced growth.


Assuntos
Terapia por Captura de Nêutron de Boro , Nanopartículas , Boro , Fosfolipídeos , Compostos de Boro/uso terapêutico , Óxidos
2.
Nanomedicine ; 49: 102659, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36822335

RESUMO

Boron neutron capture therapy shows is a promising approach to cancer therapy, but the delivery of effective boron agents is challenging. To address the requirements for efficient boron delivery, we used a hybrid nanoparticle comprising a carborane = bearing pullulan nanogel and hydrophobized boron oxide nanoparticle (HBNGs) enabling the preparation of highly concentrated boron agents for efficient delivery. The HBNGs showed better anti-cancer effects on Colon26 cells than a clinically boron agent, L-BPA/fructose complex, by enhancing the accumulation and retention amount of the boron agent within cells in vitro. The accumulation of HBNGs in tumors, due to the enhanced permeation and retention effect, enabled the delivery of boron agents with high tumor selectivity, meeting clinical demands. Intravenous injection of boron neutron capture therapy (BNCT) using HBNGs decreased tumor volume without significant body weight loss, and no regrowth of tumor was observed three months after complete regression. The therapeutic efficacy of HBNGs was better than that of L-BPA/fructose complex. BNCT with HBNGs is a promising approach to cancer therapeutics.


Assuntos
Terapia por Captura de Nêutron de Boro , Neoplasias , Humanos , Nanogéis , Boro , Neoplasias/radioterapia , Neoplasias/tratamento farmacológico , Compostos de Boro , Frutose
3.
Int J Mol Sci ; 23(9)2022 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-35563077

RESUMO

Developing photoactivatable theranostic platforms with integrated functionalities of biocompatibility, targeting, imaging contrast, and therapy is a promising approach for cancer diagnosis and therapy. Here, we report a theranostic agent based on a hybrid nanoparticle comprising fullerene nanocrystals and gold nanoparticles (FGNPs) for photoacoustic imaging and photothermal therapy. Compared to gold nanoparticles and fullerene crystals, FGNPs exhibited stronger photoacoustic signals and photothermal heating characteristics by irradiating light with an optimal wavelength. Our studies demonstrated that FGNPs could kill cancer cells due to their photothermal heating characteristics in vitro. Moreover, FGNPs that are accumulated in tumor tissue via the enhanced permeation and retention effect can visualize tumor tissue due to their photoacoustic signal in tumor xenograft model mice. The theranostic agent with FGNPs shows promise for cancer therapy.


Assuntos
Fulerenos , Nanopartículas Metálicas , Nanopartículas , Neoplasias , Técnicas Fotoacústicas , Animais , Linhagem Celular Tumoral , Fulerenos/química , Ouro/química , Humanos , Nanopartículas Metálicas/uso terapêutico , Camundongos , Nanopartículas/química , Neoplasias/diagnóstico por imagem , Neoplasias/terapia , Técnicas Fotoacústicas/métodos , Fototerapia/métodos , Terapia Fototérmica , Medicina de Precisão , Nanomedicina Teranóstica/métodos
4.
Opt Lett ; 38(24): 5224-7, 2013 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-24322223

RESUMO

Anthracene-doped polyphenylsiloxane (PPS) glass containing silver nanoparticles (AgNPs) of appropriate size was synthesized in a form of solid thin films for modifying light emission characteristics. The photoluminescence (PL) emission from the anthracene molecules at ~2.95 eV was resonantly coupled to the localized surface plasmon (LSP) polariton modes that were induced by the excitation of ~30 nm sized AgNPs. The increase in absorption of incident photons within a highly scattering medium, energy transfer from the localized excitons to the LSP modes, and the electrostatic Coulomb effects of the excitons in the presence of metal NPs all resulted in a significant enhancement of PL emission. The PL enhancement is dependent on the concentration of the anthracene molecules. The integrated PL intensity enhancement at the optimum concentration of anthracene molecules in the PPS glass with AgNPs is found to exceed 50.

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