Radiology-Pathology and Surgical Correlation in Astroblastoma.

Astroblastoma is a rare astrocytic glial neoplasm that affects mainly young girls, peaking between 10 and 30 years of age, with low- and high-grade manifestations. Imaging characteristics are well-described, but histopathologic and, more recently, molecular analysis is fundamental to establish the diagnosis, now based on MN1 alterations. We describe a case with typical imaging and histologic features of an MN1-altered astroblastoma.

Uncommon Glioneuronal Tumors: A Radiologic and Pathologic Synopsis.

Glioneuronal tumors are characterized exclusively by neurocytic elements (neuronal tumors) or a combination of neuronal and glial features (mixed neuronal-glial tumors). Most of these tumors occur in young patients and are related to epilepsy. While ganglioglioma, dysembryoplastic neuroepithelial tumor, and desmoplastic infantile tumor are common glioneuronal tumors, anaplastic ganglioglioma, papillary glioneuronal tumor, rosette-forming glioneuronal tumor, gangliocytoma, and central neurocytoma are less frequent. Advances in immunohistochemical and molecular diagnostics have improved the characterization of these tumors and favored the description of variants and new subtypes, some not yet classified by the World Health Organization. Not infrequently, the histologic findings of biopsies of glioneuronal tumors simulate low-grade glial neoplasms; however, some imaging findings favor the correct diagnosis, making neuroimaging essential for proper management. Therefore, the aim of this review was to present key imaging, histopathology, immunohistochemistry, and molecular findings of glioneuronal tumors and their variants.

Lipid peroxidation and total glutathione after different intensities of resistance exercise in trained men.

AIM: Since studies on resistance exercise and oxidative stress markers show contradictory results, it is not clear whether different intensities of exercise are the determinant of changes in such markers. The objective of this study was to investigate the acute effects of different intensities of resistance exercise on lipid peroxidation and total glutathione in previously resistance trained men. METHODS: Eight male subjects with at least 2 years of resistance training experience performed two different resistance exercise protocols: low-intensity (LI), 60% of one repetition maximum (1RM) and high-intensity (HI), 85% of 1RM. Both protocols involved seven exercises and subjects performed one set of each exercise. Blood samples were obtained before and immediately after exercise for lipid peroxidation and total glutathione analysis. RESULTS: The results indicated a significant difference in total workload (load multiplied by repetitions performed) between the LI and HI protocols (P<0.05) and no differences on lipid peroxidation and total glutathione after both LI and HI protocols. CONCLUSION: This study suggests that resistance exercise protocols composed of a single set of seven exercises, regardless of the intensity or total workload do not induce to oxidative stress, suggesting that volume is the main variable to induce oxidative stress in previously resistance trained individuals.