RESUMO
Percutaneous coronary intervention (PCI) for coronary revascularization in conjunction with an optimized pharmacological treatment can reduce adverse left ventricular remodeling and dysfunction in patients with acute myocardial infarction. Despite these modern therapeutic strategies a significant number of these patients continue to develop adverse cardiac remodeling and LV dysfunction which is associated with a poor prognosis. Stem and progenitor cell-based approaches for treatment of acute myocardial infarction and chronic ischemic cardiomyopathy are an interesting direction of current experimental and clinical research. The current review article provides a summary of recent developments of cell-based therapies of ischemic heart disease, including the assessment of the repair and regeneration capacity of different stem and progenitor cell populations. In addition the advantages and disadvantages of different modes of cell application and potential strategies for the improvement of stem and progenitor cell function for their use in cell-based cardiovascular therapies will be described.
Assuntos
Isquemia Miocárdica/complicações , Isquemia Miocárdica/cirurgia , Transplante de Células-Tronco/métodos , Transplante de Células-Tronco/tendências , Doença Aguda , Doença Crônica , Previsões , Humanos , Infarto do Miocárdio/complicações , Infarto do Miocárdio/cirurgiaAssuntos
Regulador de Condutância Transmembrana em Fibrose Cística/genética , Fibrose Cística/genética , Doenças do Íleo/genética , Sequência de Bases , Deleção de Genes , Heterozigoto , Humanos , Doenças do Íleo/complicações , Recém-Nascido , Enteropatias/genética , Enteropatias/patologia , Mecônio/metabolismo , Modelos Genéticos , Dados de Sequência Molecular , Mutação , Triagem Neonatal , Tripsinogênio/química , Tripsinogênio/metabolismoRESUMO
The ongoing shortage of human donor organs for transplantation has catalyzed new interest in the application of pig organs (xenotransplantation). One of the biggest concerns about the transplantation of porcine grafts into humans is the transmission of pig endogenous retroviruses (PERV) to the recipients or even to other members of the community. Although nonhuman primate models are excellently suited to mimic clinical xenotransplantation settings, their value for risk assessment of PERV transmission at xenotransplantation is questionable since all of the primate cell lines tested so far have been found to be nonpermissive for PERV infection. Here we demonstrate that human, gorilla, and Papio hamadryas primary skin fibroblasts and also baboon B-cell lines are permissive for PERV infection. This suggests that a reevaluation of the suitability of the baboon model for risk assessment in xenotransplantation is critical at this point.
Assuntos
Linfócitos B/virologia , Retrovirus Endógenos/fisiologia , Fibroblastos/virologia , Papio/virologia , Suínos/virologia , Animais , Linhagem Celular , Células Cultivadas , Técnicas de Cocultura , Retrovirus Endógenos/genética , Gorilla gorilla/virologia , Humanos , RNA Mensageiro/metabolismo , Infecções por Retroviridae/transmissão , Infecções por Retroviridae/virologia , Pele/citologia , Especificidade da Espécie , Transplante Heterólogo/efeitos adversosRESUMO
Incidental dural tears are a common complication of lumbar spine surgery, but if unrecognized cerebrospinal fluid (CSF) leakage can lead to the formation of a fistula or pseudomeningocele. Traditionally, fistulae and pseudomeningoceles have been treated with open revision surgery, but acute fistulae with direct CSF leakage through the incision site have reportedly been treated by extracorporal drainage. This report presents a case in which an established or chronic pseudomeningocele was successfully managed without open surgical repair.