RESUMO
Three new polyketides, chaetochromones A - C (1 - 3), together with a chromone (4), were isolated from the ethyl acetate extract of mangrove-derived fungus Phomopsis sp. SCSIO 41006. Their structures were elucidated by means of spectroscopic techniques (UV, IR, MS, 1D- and 2D-NMR). The absolute configurations of the new compounds were established by CD data.
Assuntos
Fungos/metabolismo , Policetídeos/química , Rhizophoraceae/microbiologia , Células A549 , Anti-Infecciosos/química , Anti-Infecciosos/isolamento & purificação , Anti-Infecciosos/farmacologia , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Cromonas/química , Cromonas/isolamento & purificação , Cromonas/farmacologia , Dicroísmo Circular , Fungos/classificação , Fungos/isolamento & purificação , Humanos , Células K562 , Espectroscopia de Ressonância Magnética , Conformação Molecular , Filogenia , Policetídeos/isolamento & purificação , Policetídeos/farmacologia , Policetídeos/toxicidade , Salmonella typhi/efeitos dos fármacos , Espectrometria de Massas por Ionização por Electrospray , Espectrofotometria Ultravioleta , Staphylococcus aureus/efeitos dos fármacosRESUMO
Two new phenyl derivatives (1 and 3), along with two new natural products (4 and 5), and three known compounds (2, 6 and 7), were isolated from an endophytic fungus Botryosphaeria sp. SCSIO KcF6. The structures of these compounds 1-7 were elucidated by the extensive 1D and 2D-NMR and HRESIMS Data analysis, and compared with those of reported data. The absolute configuration of the compounds 1 and 3 were assigned by optical rotation and CD data. The isolated compounds were evaluated for their cytotoxic, anti-inflammatory (COX-2) and antimicrobial activities. Compound 3 exhibited a specific COX-2 inhibitory activity with the IC50 value of 1.12 µM.