RESUMO
Langerhans cell histiocytosis (LCH) is a rare systemic disease caused by proliferation of mature histiocytes; its association to histiocyto fibroma is rarely reported. It rarely affects adults. We report a case of systemic LCH, in an adult patient with osteolytic lesion causing a fistula between the left nasal cavity and hard palate, involving the bone, lung, lymph node and associated to multiple histiocyto fibroma. The patient was operating for a fistula, and he was treated by chemotherapy and corticosteroids. Langerhans´ cell histiocytosis is a rare case, especially in adult patient. The diagnosis was based on histological and immunohistochemical analyses. This patient was treated by steroids and chemotherapy.
Assuntos
Histiocitose de Células de Langerhans/diagnóstico , Cavidade Nasal/anormalidades , Fístula Bucal/diagnóstico , Corticosteroides/administração & dosagem , Adulto , Histiocitose de Células de Langerhans/complicações , Histiocitose de Células de Langerhans/tratamento farmacológico , Humanos , Masculino , Cavidade Nasal/cirurgia , Fístula Bucal/etiologia , Fístula Bucal/cirurgia , Vimblastina/administração & dosagemAssuntos
Neoplasias da Mama/complicações , Esclerodermia Localizada/classificação , Biomarcadores/análise , Biomarcadores/sangue , Neoplasias da Mama/diagnóstico , Tratamento Farmacológico/métodos , Feminino , Fator de Transcrição GATA3/análise , Fator de Transcrição GATA3/sangue , Humanos , Queratina-7/análise , Queratina-7/sangue , Pessoa de Meia-Idade , Cuidados Paliativos/métodos , Esclerodermia Localizada/etiologiaRESUMO
Adenocarcinomas of intestinal type arising in mature cystic teratoma of ovary (MCT) are extremely rare and remain a diagnostic dilemma because of its similarities with MCT. Serum tumor markers CEA and SCC and also MRI may help in the preoperative diagnosis. Pathologist experience helps in intraoperative diagnosis.
RESUMO
To assess the prognostic value and clinicopathological correlate of the expression of topoisomerase II alpha, ki67, and p53 in non muscle-invasive urothelial bladder carcinoma. Seventy one cases of formalin-fixed, paraffin-embedded bladder biopsy specimens diagnosed as non muscle invasive urothelial carcinoma were processed by searching our surgical pathology files from 2001-2003. The patients were followed-up for 3-77 months (median = 28). In each case, one tissue block was chosen for immunohistochemical expression of ki67, topoisomerase II alpha and p53. This expression was associated with the pathological stage, grade, recurrence, progression and survival. Positive staining of topoisomerase II alpha, ki67, and p53 was found respectively in 39.5, 38, and 38% cases. We have found a statistically significant correlation between the expression of each of the 3 markers and WHO grade and recurrence. The surexpression of topoisomerase II alpha was associated within increased tumor stage. p53 was associated with tumor progression. On multivariate analysis, p53 was an independent factor of progression into muscle-invasive tumors and none of these markers had predictive value on recurrence. The present findings support the clinical relevance of these markers in bladder cancer.