Morphologic impact of four surgical techniques to correct excessive tibial plateau angle in dogs: A theoretical radiographic analysis.

OBJECTIVE: To determine morphologic differences between four tibial osteotomy techniques used to correct excessive tibial plateau angle (eTPA). STUDY DESIGN: Retrospective radiographic analysis. SAMPLE POPULATION: Sixteen dogs (27 tibias) with eTPA. METHODS: Virtual corrections of eTPA were performed on sagittal plane radiographs of canine tibia using four tibial osteotomy techniques and categorized into respective groups. Group A represented the center of rotation of angulation (CORA)-based leveling osteotomy (CBLO) and coplanar cranial closing wedge ostectomy (CCWO), Group B the tibial plateau leveling osteotomy (TPLO) and CCWO, Group C the modified CCWO (mCCWO), and Group D the proximal tibial neutral wedge osteotomy (PTNWO). Pre- and post-correction TPA, tibial length and mechanical cranial distal tibial angle (mCrDTA) were measured and compared. RESULTS: Mean TPA prior to correction was 42.67 ± 6.1°. Post-correction mean TPAs were 10.47 ± 2.1°, 6.77 ± 1.6°, 4.76 ± 1.5°, and 7.09 ± 1.3° for Groups A, B, C, and D, respectively. TPA correction accuracy in Groups A and D varied least from target TPAs. Tibial shortening was documented in Group B in contrast to other groups. The greatest mechanical axis shift was identified in Group A. CONCLUSION: Each technique achieved TPA < 14° despite having different effects on tibial morphology including alteration of tibial length, mechanical axis shift and variation in correctional accuracy. CLINICAL SIGNIFICANCE: Despite all methods being able to correct eTPA, the choice of technique will affect morphology in unique ways and should be considered prior to surgery to consider the implications in a given patient.

Pelvic limb anesthesia and analgesia in dogs undergoing tibial plateau leveling osteotomy (TPLO): A survey of board-certified anesthesiologists.

OBJECTIVE: To report the locoregional anesthesia and analgesia preferences of veterinary anesthesiologists for use in dogs undergoing a TPLO and determine any association with specialty college, time from board-certification, or employment sector. STUDY DESIGN: Cross sectional study. SAMPLE POPULATION: Diplomates of the American (ACVAA) and European (ECVAA) Colleges of Veterinary Anesthesia and Analgesia. METHODS: An electronic survey was distributed to diplomates and responses were used to determine associations between preferred methods. RESULTS: The survey response rate was 28% (141/500) with 69% (97/141) of ACVAA diplomates and 31% of diplomates with ECVAA (44/141) certification. Peripheral nerve block (PNB) was preferred by 79% (111/141) of all diplomates, lumbosacral epidural (LE) by 21% (29/141), and peri-incisional infiltration (PI) by <1% (1/141). There was no association (p = .283) with specialty college. There was an association (p < .001) with time from board-certification with increased preference for LE when >10-years from certification and PI preferred by only those board-certified >20-years ago. There was an association with employment sector (p = .003) with more academic diplomates preferring LE. Anesthesiologists reported that treatment decisions were affected by various factors including time pressure and surgeon influence. CONCLUSION: Diplomates of ACVAA and ECVAA prefer PNB as the locoregional method of pelvic limb anesthesia in dogs undergoing TPLO. A greater percentage of newer and private practice diplomates prefer PNB while a larger percentage of senior and academic diplomates prefer LE. Decision making is multifactorial and includes perceived time pressure and surgeon influence. CLINICAL SIGNIFICANCE: Veterinary anesthesiologists prefer and frequently use PNB in dogs undergoing TPLO and surgeon influence may affect their chosen treatment.

Comparison of two postoperative complication grading systems after treatment of stifle and shoulder instability in 68 dogs.

OBJECTIVE: (1) To adapt and apply the Clavien-Dindo (aCD) postoperative complication grading system to dogs experiencing complications following a single orthopedic procedure. (2) To compare the reliability of the Clavien-Dindo system to the Cook complication grading system. STUDY DESIGN: Retrospective study. SAMPLE POPULATION: Sixty-eight client-owned dogs. METHODS: Scenarios derived from complications following TightRope stabilization of the stifle and shoulder were graded by four ACVS-boarded surgeons using two systems; the Cook 3-point scale and the aCD 5-point scale. Because the aCD system distinguishes complications from outcomes ("sequelae" or "failure to cure"), two data sets were created: one with (n = 76) and without (n = 67) inclusion of "sequelae" and "failure to cure" cases. Interobserver reliability was evaluated using intraclass correlation coefficient (ICC) calculations. RESULTS: Seventy-six scenarios from 68 records were evaluated. The ICC of the aCD system was 0.620 consistent with moderate reliability. The reliability of the Cook system was good, with an ICC of 0.848. Exclusion of cases with "sequelae" or "failure to cure" resulted in excellent reliability of the aCD system (ICC = 0.975) and good reliability of the Cook systems (ICC = 0.857). CONCLUSION: The aCD grading system was less reliable than the Cook system when evaluating all cases but more reliable when evaluating cases of complications excluding "sequelae" and "failures to cure". CLINICAL SIGNIFICANCE: The Cook grading system is reliably good in grading postoperative complications in dogs. The aCD system can also be used to assess postoperative complications with excellent reliability but is less reliable when distinguishing complications from other postoperative outcomes.

Abstract Presentation at Two Veterinary Surgery Conferences and the Impact on Publication Rate.

OBJECTIVES: The aim of this study was to compare the publication rate (PR) and report descriptive findings from abstracts presented at the American College of Veterinary Surgeons (ACVS), the Veterinary Orthopaedic Society (VOS), and those presented at both conferences. STUDY DESIGN: All conference abstracts from 2001 to 2010 ACVS and VOS meetings were reviewed. PR in peer-reviewed journals was evaluated and compared between Group 1 (abstracts presented at ACVS only; n = 1,277), Group 2 (abstracts presented at VOS only; n = 645), and Group 3 (abstracts presented at both conferences; n = 121) abstracts. Abstracts were assigned a level of evidence (LoE) score. RESULTS: Approximately 6% of all abstracts evaluated were presented at two scientific meetings (Group 3). The PR of Group 1 (66%) and Group 3 (62%) abstracts was significantly higher than that of Group 2 (45%). The majority of abstracts were assigned a low LoE (3 or 4). Once presented, most Group 3 abstracts took <12 months to be submitted and <24 months to be published. CONCLUSION: This study found that a limited number of abstracts were presented at both ACVS and VOS, and PR was significantly different between those presented at ACVS only or both ACVS and VOS compared with VOS only. There was no significant difference in PR between Group 1 and Group 3 abstracts. This study has provided the initial comparison between abstracts presented at two veterinary surgical conferences.

Best practices for measuring and reporting ground reaction forces in dogs.

Kinetic gait analysis and ground reaction forces (GRFs) have been used in hundreds of scientific manuscripts. Specific methodology, interpretation of results, and translation to clinical veterinary medicine have been inconsistent. This impedes the advance of veterinary medicine and poses a risk to patients. The objective of this report was to address methodological variations and share our consensus on a recommended approach with viable alternatives to data collection methods, analysis, reporting, and interpretation for GRFs in the dog. Investigators with experience performing kinetic gait analysis reviewed the literature and discussed the topics that most influenced GRF data collection, reporting, and interpretation. Methodological variations were reported and a consensus from the group was devised. There are several reasonable alternatives to collect, report, and interpret GRFs in dogs appropriately. Attention to detail is required in several areas to collect and report them. This review and consensus report should assist future investigations and interpretations of studies, optimize comparison between publications, minimize use of animals, and limit the investment in cost and time.

Efficacy of postoperative antibiotic use after tibial plateau leveling osteotomy in dogs: A systematic review.

OBJECTIVE: A systematic review of published data to determine whether postoperative antibiotic use after tibial plateau leveling osteotomy (TPLO) decreases infection rates. STUDY DESIGN: Systematic review. METHODS: A broad bibliographic search was performed in three online databases through March 2020 for publications on postoperative antibiotic use after TPLO in dogs. Search terms included dog, canine, TPLO, tibial plateau leveling osteotomy, infection, antibiotic, and antimicrobial. Articles that met inclusion criteria were evaluated for level of evidence (LoE) by a modified Oxford Level of Evidence (mOLE) and GRADE (Grading of Recommendations, Assessment, Development and Evaluation) classification and evaluation. RESULTS: Thirteen studies met the inclusion criteria. Effect of antibiotic use was the primary question in four studies. Among those, 50% (2/4) were assigned a mOLE of 1b and a GRADE of moderate, while the other 50% (2/4) were assigned a mOLE of 4b or 4c with a GRADE of low. The two studies with the highest LoE did not provide evidence of the benefit of antibiotic usage. Results of only one study provided evidence to support the use of postoperative antibiotics. The remaining nine studies provided evaluation of antibiotic use secondarily and were all assigned a low LoE. Among these, 78% (7/9) provided evidence to support the use of postoperative antibiotics. CONCLUSION: We found little evidence to support the use of postoperative antibiotics to reduce the risk of surgical site infections in dogs after TPLO. The answer to this clinical question is complicated by the lack of prospective studies and inconsistent treatment protocols in the evaluated studies. CLINICAL SIGNIFICANCE: The clinical impact of postoperative antibiotic administration on infection rates after TPLO is uncertain.

A Pilot Study of Cancer-Induced Bone Pain Using Validated Owner Questionnaires, Serum N-Telopeptide Concentration, Kinetic Analysis, and PET/CT.

Cancer-induced bone pain, despite its frequency and severity, is a poorly understood phenomenon in people and animals. Despite excitement regarding translational osteosarcoma studies, there is a lack of attention toward examining cancer pain in dogs. In this pilot study, we used a multimodal pain assessment methodology to evaluate pain relief after therapeutic intervention in dogs with primary bone cancer. We hypothesized that intervention would cause objective evidence of pain relief. Evaluations of 8 dogs with primary bone cancer included 18F-FDG PET/CT scans, kinetic analysis, validated owner questionnaires (Canine Brief Pain Inventory, canine BPI), and serum N-telopeptide (NTx) concentration. Dogs were routinely staged and had 18F-FDG PET/CT scans prior to treatment with day 0, 7, 14, and 28 canine BPI, serum NTx, orthopedic exam, and kinetic analysis. Dogs treated with zoledronate and radiation underwent day 28 18F-FDG PET scans. All clinical trial work was approved by the University of Missouri IACUC. Four dogs underwent amputation (AMP) for their appendicular bone tumors; four received neoadjuvant zoledronate and hypofractionated radiation therapy (ZOL+RT). Canine BPI revealed significant improvements in pain severity and pain interference scores compared to baseline for all dogs. Positive changes in peak vertical force (+16.7%) and vertical impulse (+29.1%) were noted at day 28 in ZOL+RT dogs. Dogs receiving ZOL+RT had a significant (at least 30%) reduction in serum NTx from baseline compared to amputated dogs (p = 0.029). SUVmax (p = 0.11) and intensity (p = 0.013) values from PET scans decreased while tumor uniformity (p = 0.017) significantly increased in ZOL+RT-treated tumors; gross tumor volume did not change (p = 0.78). Owner questionnaires, kinetic analysis, and 18F-FDG PET/CT scans showed improved pain relief in dogs receiving ZOL+RT. Serum NTx levels likely do not directly measure pain, but rather the degree of systemic osteoclastic activity. Larger, prospective studies are warranted to identify the ideal objective indicator of pain relief; however, use of multiple assessors is presumably best. With improved assessment of pain severity and relief in dogs with cancer, we can better evaluate the efficacy of our interventions. This could directly benefit people with cancer pain, potentially decreasing the amount of subtherapeutic novel drugs entering human clinical trials.

Publication Rate and Evidence-Based Evaluation of Abstracts Presented at the Annual Veterinary Orthopedic Society Conference.

OBJECTIVES: Scientific abstracts are a common method for disseminating new research. There is no information on the publication rate of orthopaedic surgery abstracts presented at the annual Veterinary Orthopedic Society (VOS) Conference. The objectives of this study were to document the publication rate, the publication timeline and the level of evidence (LoE) of abstracts presented at an annual orthopaedic meeting. STUDY DESIGN: All conference abstracts from the 2001 to 2014 annual VOS meeting were reviewed, and final publication was determined through a comprehensive bibliographic search. RESULTS: Over 14 conferences, 1,112 scientific abstracts were presented with an overall publication rate of 47%. The majority of abstracts had low LoE scores, and those abstracts were published less timely than ones with higher LoE scores. Once presented, most abstracts took 1 year to be submitted and 2 years to be published. Dog (45%) and ex vivo (19%) studies were the most common. Publication occurred most frequently in Veterinary Surgery (40%), Veterinary and Comparative Orthopaedics and Traumatology (17%) and the American Journal of Veterinary Research (12%). CONCLUSION: The publication rate for abstracts presented at the annual VOS meeting is lower than those from a more generalized veterinary surgery conference. Publication occurs most frequently in a select group of journals, and the subject matter is limited in scope with a focus on dog and ex vivo studies. Overall, most abstracts presented at VOS contain a lower LoE.

Review of kinematic analysis in dogs.

Objective gait analysis techniques aid investigators in the study of motion. Kinematic gait analysis techniques that objectively quantitate motion are valuable tools used to understand normal and abnormal motion in domestic animals. Recent advances in video technology have made the study of motion more readily accessible. Available systems can document gait in two or three dimensions (2D or 3D, respectively). Knowledge of fundamental gait analysis concepts is critical to generating meaningful data. The objective of this report is to review principles of kinematic data collection and analyses, with a focus on differences between 2D and 3D systems.

Radiographic determination of normal canine femoral alignment in the sagittal plane: A cadaveric pilot study.

OBJECTIVE: To establish a reliable methodology for radiographic determination of alignment of the normal canine femur in the sagittal plane. STUDY DESIGN: Cadaveric pilot study. SAMPLE POPULATION: Twenty-nine cadaveric canine femurs. METHODS: Femoral specimens were collected from the University of Missouri veterinary anatomy laboratory, and standardized sagittal plane radiographs were obtained. The anatomic and mechanical axes, joint orientation, lines and joint orientation angles were determined in the sagittal plane by using the center of rotation of angulation methodology. Landmarks were clearly described to allow repeatability and reliability of measurements. Three observers with various degrees of experience measured two centers of rotation of normal angulation, the anatomic caudoproximal femoral angle, and the mechanical caudodistal femoral angle for all femurs on three separate days. Interobserver and intraobserver reliability were measured by using two-way mixed intraclass correlation coefficients (ICC) with associated 95% CI. RESULTS: Twenty-nine medium to large breed canine femora were measured. A high degree of correlation was present both among and between observers for all measurements performed, as defined by an ICC >0.8 for each. CONCLUSION: The described methodology was reliable and repeatable for measurement of angulation of grossly normal canine femora in the sagittal plane when performed by observers with varying degrees of clinical experience, as evidenced by a high degree of correlation for all values measured. CLINICAL SIGNIFICANCE: This methodology may be used for standardized evaluation of alignment of canine femora in the sagittal plane.

Treatment of idiopathic chylothorax in dogs and cats: A systematic review.

OBJECTIVE: To evaluate the evidence published on the treatment of idiopathic chylothorax (IC) in small animals. STUDY DESIGN: Systematic literature review. SAMPLE POPULATION: Dogs and cats with IC. METHODS: A literature search was performed in three bibliographic databases in July 2018 for publications on IC in dogs and cats. Articles meeting criteria for inclusion were evaluated for treatment, survival, outcome data, and level of evidence (LoE) with a modified Oxford Level of Evidence (mOLE) and GRADE (Grading of Recommendations, Assessment, Development and Evaluations) system. RESULTS: Eleven of 313 identified articles met the inclusion criteria. Only one study was identified in dogs as having higher LoE by using the mOLE system, whereas no study was identified as such in either species with the GRADE system. Surgery was the primary treatment in all dogs and in 93% (68/73) of cats. Medical therapy was the primary treatment in 7% (5/73) of cats. The most common surgical treatment combined thoracic duct ligation (TDL) and subtotal pericardiectomy (SP; 40%; 34/84) in dogs and TDL in cats (51% [37/73]). CONCLUSION: The body of literature for IC treatment in small animals was limited to one higher LoE study in dogs and none in cats. No strong conclusion could be drawn regarding the effectiveness of any one surgical method in dogs or cats, and no evidence was found to support medical therapy as a primary treatment. CLINICAL SIGNIFICANCE: The best available evidence regarding the treatment of IC is published in dogs and provides some support for surgical treatment with either TDL + cisterna chyli ablation or TDL + SP. Additional evidence is required to confirm this finding.

Pelvic limb kinematics in the dog with and without a stifle orthosis.

OBJECTIVE: To report a method of evaluating 3-dimensional joint motion in dogs with a stifle orthosis. STUDY DESIGN: Experimental. ANIMALS: Six healthy dogs. METHODS: Three-dimensional pelvic limb joint motion was recorded with and without a stifle orthosis. Kinematic data were collected from dogs at a walk and trot for the hip, stifle, and tarsus prior to, and after application of, a stifle orthosis. Data were also obtained for the orthosis alone. Comparisons were made between the braced and unbraced limb, and between the braced limb and the orthosis alone. Complete waveforms, kinematic, and temporospatial variables were compared. RESULTS: Gait waveforms differed between braced and unbraced limbs for all joints and planes of motion (P < .05), as well as between the braced stifles and the orthosis alone at both a walk and trot. However, joint ROM was inconsistently altered. The effect of bracing on stifle ROM was limited to a reduced extension at the end of stance. Adjacent joint ROM was affected by the stifle orthosis. Temporospatial variables were predominantly affected while walking. CONCLUSIONS: The restrictive motion of the stifle orthosis is not fully translated to the underlying joint, based on the limited differences between the motion of braced and unbraced stifles. This effect varies with plane of motion and phase of the gait cycle, with most changes in stifle motion being detected during the stance phase. The stifle orthosis had an equal or greater effect on the motion of adjacent joints, especially the tarsus.

Elevated synovial fluid concentration of adenosine triphosphate in dogs with osteoarthritis or sodium urate-induced synovitis of the stifle.

Adenosine triphosphate has been shown to stimulate nociceptive nerve terminals in joints. Elevated synovial fluid adenosine triphosphate concentrations as well as a correlation between synovial fluid adenosine triphosphate concentrations and osteoarthritic knee pain has been demonstrated in humans, but not yet in dogs. This study documented elevated synovial fluid adenosine triphosphate concentrations in the stifles of dogs with secondary osteoarthritis and urate-induced synovitis, as compared to normal stifles.

Publication Rate and Evidence-Based Evaluation of Abstracts Presented at the American College of Veterinary Surgeon's Annual Meeting.

OBJECTIVE: To document the publication rate of abstracts presented at 10 ACVS conferences and report the time required for publication and level of evidence. STUDY DESIGN: Literature review. METHODS: All scientific abstracts published in the ACVS proceedings from 2001 to 2010 were reviewed. The level of evidence of each abstract was evaluated and scored (1-4). Publication information was determined after a broad bibliographic search through multiple online databases. RESULTS: The overall publication rate for ACVS abstracts (n=1,395) was 66% and 11% were published before conference presentation. The majority of abstracts focused on the dog (35%) or the horse (33%). Most (90%) abstracts were submitted to veterinary-based journals. The median time (interquartile range [IQR]) from abstract presentation to journal submission was 222 days (107-541), from journal submission to acceptance for publication was 122 days (89-185), and from acceptance to publication in a journal was 208 days (151-289). The time from abstract presentation to final publication took 449 days (238-794). Of the abstracts, 4% were of level 1 evidence, 9% level 2, 66% level 3, and 21% level 4. Studies with a higher level of evidence were submitted, accepted, and published quicker than ones with a lower level of evidence. The publication rate was 61%, 71%, 68%, and 65% for level 1, 2, 3, 4 evidence, respectively. CONCLUSION: The publication rate of scientific abstracts presented at the ACVS conferences is comparable to other biomedical conferences. The subject matter is limited in scope and focused mainly on dogs or horses. Most abstracts contained lower level of evidence. Studies with higher levels of evidence were submitted, accepted, and published more timely. However, the publication rate was similar for abstracts of all levels of evidence.

The Effect of Examiner Variability on Multiple Canine Stifle Kinematic Gait Collections in a 3-Dimensional Model.

OBJECTIVE: To evaluate examiner variability in a superficial skin marker model of canine stifle kinematics. STUDY DESIGN: Experimental. ANIMALS: Six clinically normal dogs. METHODS: Dogs had 11 retroreflective markers fixed to the skin on the right hindlimb. Dogs were trotted 5 times through the calibrated testing space and this was repeated on 4 different testing days. Examiner A applied all markers to a dog and collected 6 good trials for analysis. The markers were then removed and Examiner B immediately repeated the process on the same dog. This was repeated for each dog on the 4 testing days. The dogs were trotted at a velocity of 1.70-2.10 m/s through the testing space to obtain the dynamic data sets. Comparisons were performed with Fourier analysis and Generalized Indicator Function Analysis (GIFA). Significance was set at P < .05 for all comparisons. RESULTS: Fourier analysis and GIFA found differences within and between examiners. Fourier analysis found no differences in sagittal and transverse planes for the experienced (A) and novice examiner (B), respectively. Fourier analysis detected fewer differences for the experienced examiner (A). CONCLUSION: Variability occurs within and between examiners using the same kinematic model. Transverse and frontal plane kinematics produce variable results between examiners. Prior experience with the model reduces the amount of variability and results in consistent and repeatable sagittal plane kinematic data collection.

Treatment of intestinal pythiosis in a dog with a combination of marginal excision, chemotherapy, and immunotherapy.

CASE DESCRIPTION: A 1.5-year-old mixed-breed dog was examined because of a 1-month history of anorexia, vomiting, diarrhea, and weight loss. CLINICAL FINDINGS: The dog was very thin on physical examination (body condition score, 3/9). Results of all diagnostic tests were within reference limits except intestinal thickening and lymphadenopathy were identified on abdominal ultrasound examination. During exploratory laparotomy, thickening at the ileocecal-colic junction and within the transverse colon and mesenteric lymphadenopathy were identified, and the ileocecal-colic junction was resected. Histopathologic evaluation of the ileocecal-colic junction and full-thickness biopsy specimens from other sites as well as results of a serum ELISA were diagnostic for gastrointestinal Pythium insidiosum infection. TREATMENT AND OUTCOME: Pythiosis was initially treated medically with administration of itraconazole and terbinafine by mouth, but the colonic lesion was progressive with this regimen. Two months after diagnosis, a subtotal colectomy was performed; marginal excision (0.6 cm) was obtained at the aboral margin. The dog was treated with 3 doses of a pythiosis vaccine beginning approximately 2 weeks after surgery and was continued on itraconazole and terbinafine for 5 months. Parenteral and enteral nutrition as well as considerable general supportive care were required postoperatively. Six months after treatment, the dog had a normal serum ELISA titer. Two years after treatment, the dog had returned to preoperative weight and was clinically normal. CLINICAL RELEVANCE: This patient had an unusually positive therapeutic response to chronic, extensive, marginally excised gastrointestinal pythiosis.

The effect of marker location variability on noninvasive canine stifle kinematics.

OBJECTIVE: Evaluate the effect of marker placement on kinematics of the canine stifle in 3 distinct hindlimb models. STUDY DESIGN: In vivo biomechanical study. ANIMALS: Normal adult mixed-breed dogs (n=5). METHODS: Ten retroreflective markers were affixed to the skin on the right rear leg of each dog to establish normal stifle kinematics. Four additional markers were placed around the greater trochanter (GT), 2 m cranial, caudal, dorsal, and ventral to evaluate single marker placement variability on kinematic model data. Dogs were walked and trotted 5 times through the calibrated space. Sagittal flexion and extension angle waveforms were acquired during each trial with 3 models that were produced simultaneously during each gait. The GT marker was reassigned to 1 of the 4 additional locations (cranial, caudal, dorsal, and ventral) to alter the kinematic model. Comparison of sagittal flexion and extension angle waveforms was performed with Generalized Indicator Function Analysis. RESULTS: Each model provided consistent equivalent sagittal flexion-extension data. Analysis revealed statistically significant differences between all GT locations. The differences were greatest in the cranial and caudal locations for all models. CONCLUSIONS: Deviation of the GT marker in the cranial/caudal direction from an anatomically normal position produces a greater degree of difference than deviation in a dorsal/ventral direction.

Effects of firocoxib, meloxicam, and tepoxalin administration on eicosanoid production in target tissues of healthy cats.

OBJECTIVE: To evaluate the effects of firocoxib, meloxicam, and tepoxalin administration in healthy cats by measuring the ability of stimulated tissues to synthesize eicosanoids ex vivo. ANIMALS: 8 healthy adult male cats. PROCEDURES: In a blinded, randomized, crossover study design, cats were treated with firocoxib (1 mg/kg, PO, q 24 h), meloxicam (0.05 mg/kg, PO, q 24 h), tepoxalin (5.0 mg/kg, PO, q 12 h), or a placebo for 8 days. Blood samples and gastric and duodenal mucosal biopsy specimens were collected on days 0 (baseline; immediately before treatment), 3, and 8 of each treatment period. Thromboxane B2 (TXB2) concentrations were measured in serum, and prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) concentrations were measured in plasma. Prostaglandin E1 (PGE1) synthesis, PGE2 synthesis, and LTB4 concentrations were measured in mucosal biopsy specimens. A 21-day minimum washout period was observed between treatments. Repeated-measures analyses were performed. RESULTS: Firocoxib and meloxicam administration resulted in a lower plasma PGE2 concentration than at baseline on days 3 and 8 of administration, whereas tepoxalin administration did not. Tepoxalin administration resulted in a lower serum TXB2 concentration and pyloric and duodenal PGE1 synthesis on both days, compared with baseline and placebo administration. Neither firocoxib nor meloxicam administration altered pyloric or duodenal PGE1 synthesis on either day, compared with placebo administration. Tepoxalin administration also resulted in lower pyloric mucosal LTB4 concentrations on both days, compared with baseline values. CONCLUSIONS AND CLINICAL RELEVANCE: Firocoxib and meloxicam administration had no effect on cyclooxygenase-1 activity, whereas tepoxalin administration resulted in inhibition of cyclooxygenase-1 and 5-lipoxygenase.

Comparison of canine stifle kinematic data collected with three different targeting models.

OBJECTIVE: To model the kinematics of the canine stifle in 3 dimensions using the Joint Coordinate System (JCS) and compare the JCS method with linear and segmental models. STUDY DESIGN: In vivo biomechanical study. ANIMALS: Normal adult mixed breed dogs (n=6). METHODS: Dogs had 10 retroreflective markers affixed to the skin on the right pelvic limb. Dogs were walked and trotted 5 times through the calibrated space and the procedure was repeated 5 days later. Sagittal flexion and extension angle waveforms acquired during each trial with all 3 models (JCS, Linear, and Segmental) were produced simultaneously during each gait. The JCS method provided additional internal/external and abduction/adduction angles. Comparison of sagittal flexion and extension angle waveforms was performed with generalized indicator function analysis (GIFA) and Fourier analysis. A normalization procedure was performed. RESULTS: Each model provided consistent equivalent sagittal flexion-extension data. The JCS provided consistent additional internal/external and abduction/adduction. Sagittal waveform differences were found between methods and testing days for each dog at a walk and a trot with both GIFA and Fourier analysis. After normalization, differences were less with Fourier analysis and were unaltered with GIFA. CONCLUSIONS: Whereas all methods produced similar flexion-extension waveforms, JCS provided additional valuable data. CLINICAL RELEVANCE: The JCS model provided sagittal plane flexion/extension data as well as internal/external rotation and abduction/adduction data.

Revision of cemented total hip arthroplasty with cementless components in three dogs.

OBJECTIVE: To report revision of cemented total hip arthroplasty failure with cementless components in 3 dogs. STUDY DESIGN: Clinical case reports. ANIMALS: Dogs with total hip arthroplasty failure (n=3). METHODS: Cementless total hip arthroplasty revision was performed in 3 dogs with previously cemented femoral and acetabular components. All dogs required revision of the femoral component and 1 dog also required revision of the acetabular component. RESULTS: Revisions resulted in a stable functional prosthesis with successful bone integration. CONCLUSIONS: Use of cementless components may be a viable option for revision of loosened cemented prosthesis after explantation of failed cemented canine total hip replacements. CLINICAL RELEVANCE: Failed canine-cemented total hip arthroplasties can be successfully revised with cementless components.