[A Case of Maxillary Gingival Carcinoma Possibly Caused by Chronic Inflammation Related to Oral Candidiasis].

Oral candidiasis infection is generally treated with antifungal agents. However, it often requires long-term treatment, and epithelial dysplasia may persist even after the infection has been resolved depending on the case. Malignant transformation has been reported in long-term cases involving chronic inflammation, and surgical excision should be performed as the treatment of choice when the treatment period is prolonged. This report describes a case of maxillary gingival carcinoma caused by chronic inflammation related to oral candidiasis. The patient was an 85-year-old man who was admitted to our hospital with maxillary gingival pain. Cytology and biopsy revealed oral candidiasis and squamous cell carcinoma(cT1N0M0, Stage Ⅰ). He underwent partial maxillectomy. Post-operative recovery was uneventful, and there was no sign of recurrence or metastasis at the 1-year follow-up.

[Feasibility of a Heart-Shaped Modified Pectoralis Major Myocutaneous Flap for a Stabilized Vascular Supply in the Reconstruction of Surgically Induced Defects in Patients with Advanced Oral Cancer].

The pedicled pectoralis major myocutaneous(PMMC)flap, used for the reconstruction of surgical defects in advanced oral cancer resection, is versatile and can be obtained without a highly-invasive procedure. However, flap utility is limited by an unstable blood supply and the relatively high rate of partial necrosis of the skin island. Thus, the use of microvascularized free flaps has become more common in patients requiring oral-maxillofacial reconstruction. Detailed angiographic studies revealed the 3-dimensional vascular anatomy of the PMMC flap. This allowed us to obtain a modified, heart-shaped flap with a skin island that includes the intramuscular vascular networks between the pectoral branches of the thoracoacromial vessels and the intercostal perforators of the internal mammary vessels, thus ensuring a sufficient blood supply and stable survival of the flap. We have used this technique since 2015 to treat 7 patients with locally advanced or recurrent(salvage)oralcancer. None developed critical flap problems, and survival of the total skin island was successfully obtained in all cases. Transfer of the heart-shaped PMMC, including the multiple intercostal perforators from the internal mammary vessels, may contribute to a stable blood supply of the skin island and therefore can be effective for advanced oral cancer reconstruction.

[Clinicopathological Study of the Resected Oral Leukoplakia Cases].

Oral leukoplakia is the most common premalignant or potentially malignant lesion in the oral mucosa. This retrospective study examined 67 lesions from 62 patients with clinical diagnoses of oral leukoplakia who underwent surgical excision in our department from 2015 to 2017. The patients comprised 22 men and 40 women. The most common location of the lesion was the lower gingiva, followed by the tongue, upper gingiva, buccal mucosa, palate, and lip. The most common clinical type was the white-spotted, followed by erythroleukoplakia, hillock, and verrucous types. Histopathologically, 16 lesions were oral intraepithelial neoplasia, whereas five were squamous cell carcinoma. The data identified several characteristics of oral leukoplakia that predict a high risk of malignant transformation and require aggressive surgical resection.