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1.
Libyan J Med ; 18(1): 2258670, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37731357

RESUMO

Objectives: Benign category of Bethesda classification is generally well known to carry a false-negative rate of 0-3%. The current study was designed to investigate the rate of false-negative cytology in patients who underwent thyroidectomy for presumably benign thyroid diseases. Predictive risk factors for false results and malignancy were evaluated along with cytology-histology discrepant cases.Materials and methods: Females who underwent thyroidectomy between May 2014 and December 2022 were included. Demographics, ultrasound (US) features, fine-needle aspiration (FNA) diagnosis, surgical indications and outcomes, final histology reports, risk factors, and malignancy rate were recorded. Cytology-histology discrepant cases were further evaluated for interpretation errors and risk factors. Statistical analyses were performed using Fisher's exact and Mann-Whitney U tests.Results: Of 581 women with a benign thyroid disease who underwent thyroidectomy, 91 was diagnosed as incidental carcinoma (15.6%) and most was T1a (4.9 ± 2.7 mm, 95.6%). Final histology reports revealed mostly papillary carcinoma (93.4%). Predictors of malignancy such as age, family history, previous radiation exposure, and iodine-deficient diet did not help in risk stratification (p > 0.05, for each). However, FNA taken during pregnancy was determined as a risk factor (n = 7, 7.6%, p < 0.05) since it may cause a delay in diagnosis. Cytology-histology discrepant cases were seen to be mostly due to sampling errors (45%, p < 0.05), followed by misinterpretations (37.3%, p < 0.05). There was no reason for discrepancy in 17.5%, and this was linked to inherent nature of thyroid nodule with overlapping cytologic features. Best identifiable risk factor for misinterpretation was pregnancy as well (n = 5, 14.7%, p < 0.05).Conclusions: Risk of malignancy in a presumably benign thyroid disease should not be ignored. Radiology-cytology correlation by an experienced dedicated team may help in decreasing sampling errors. Physiologic changes caused by pregnancy may shade malignant transformation in thyrocytes, and it would be appropriate to be cautious about benign FNA taken during this period.


Assuntos
Nódulo da Glândula Tireoide , Gravidez , Humanos , Feminino , Nódulo da Glândula Tireoide/diagnóstico por imagem
2.
J Coll Physicians Surg Pak ; 30(7): 858-860, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34271793

RESUMO

Radical surgery to achieve optimal cytoreduction in locally advanced caecal cancer may dictate femoral or sciatic nerve resection, especially in cases with pelvic side-wall involvement. In such a situation, gait disturbance is inevitable. A 61-year male with a new-onset right leg limping due to locally advanced right colon carcinoma underwent cytoreductive surgery (CRS) with partial resection of right pelvic side- wall, and hyperthermic intraperitoneal chemotherapy (HIPEC). During the operation, we aimed to preserve both the sciatic and femoral nerves to prevent further deterioration of his right leg limping postoperatively. However, we did not compromise the principles of radical surgery and all tumoral implants around femoral vessels and nerves were removed. Completeness of cytoreduction score was zero (CC0). The resection of all macroscopic disease is the main goal of CRS, but as seen in our case with tumor-related walking difficulty, nerve-sparing CRS and HIPEC may prevent further deterioration of the situation. Key Words: Cytoreductive surgery, Hyperthermic intraperitoneal chemotherapy, Sciatic nerve, Femoral nerve, Caecal cancer.


Assuntos
Neoplasias do Ceco , Hipertermia Induzida , Neoplasias Peritoneais , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Terapia Combinada , Procedimentos Cirúrgicos de Citorredução , Marcha , Humanos , Quimioterapia Intraperitoneal Hipertérmica , Perna (Membro) , Masculino , Neoplasias Peritoneais/terapia , Taxa de Sobrevida
3.
Arch Dermatol Res ; 313(9): 799-803, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33433721

RESUMO

Nails have both functional and aesthetic importance. Undertreatments cause frequent recurrences affecting its functionality, while over-treatment spoils the aesthetic view. To describe the most practical and aesthetic method to treat ingrown toenail. All patients with ingrown toenail who applied to outpatient clinics of General Surgery Department between 2013 and 2019 were enrolled. A 2-mm space between tissue and nail by lateral longitudinal excision was created with only minimal matricectomy, under local anaesthesia. A total of 2334 surgical procedures were performed in 2118 patients. Recurrence rate was 1.7% during 36-month follow-up, most (70.7%) in younger men (22 years). The location of the lesions (right/left, medial/lateral or bilateral) did not show difference (p > 0.05 for each). Predisposing factors were tight-fitting footwear (4.5%), incorrect nail-trimming (3%), genetic tendency (2.8%), obesity (2.1%) and trauma (0.75%); but each was p > 0.05. Mean operation time was 3 min. There was no important complication, except hematoma (0.89%) and infection (0.68%). Mean healing time was 10 days and patients returned to daily activities in 3 days. Longitudinal excision with minimal matricectomy technique provides all dead tissue and diseased parts of nail and soft tissue to be removed. It is simple, cost-effective, satisfactory and aesthetic. SBU/23.01.2019/B.10.1.TKH.4.34.H.GP.0.01/7 (retrospectively registered).


Assuntos
Procedimentos Cirúrgicos Ambulatórios/métodos , Unhas Encravadas/cirurgia , Prevenção Secundária/métodos , Adolescente , Adulto , Fatores Etários , Procedimentos Cirúrgicos Ambulatórios/economia , Análise Custo-Benefício , Estética , Feminino , Seguimentos , Humanos , Incidência , Masculino , Unhas Encravadas/economia , Unhas Encravadas/epidemiologia , Recidiva , Fatores de Risco , Prevenção Secundária/economia , Fatores Sexuais , Dedos do Pé , Resultado do Tratamento , Cicatrização , Adulto Jovem
4.
Ann Ital Chir ; 91: 154-160, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32719186

RESUMO

PURPOSE: Both the aetiology and treatment of idiopathic granulomatous mastitis (IGM) is controversial and unnecessary resections can lead to over-treatment in such a benign disease. Our aim was to report our experience in patients with IGM managed mainly with conservative methods, such as antibiotics, drainages and corticosteroids. MATERIAL AND METHODS: Pathology database from 2008 to 2018 was reviewed retrospectively. Demographics and symptoms were documented from patient charts. Follow-up information was obtained from clinical reviews, and severity and duration of symptoms were documented. All data were transferred to Excel file and the parameters were compared. RESULTS: All 154 patients were women. Mean age was 35.9 years. Empiric broad-spectrum antibiotic, abscess drainage and steroid treatments were seen to be successful in most of the cases (95.4%). In patients with limited regression (2.5%) or persistant lesions (1.9%), a second cycle was employed with a total regression rate of 100%. Recurrence was seen one or two times in 23 (14.9%) and 2 (1.2%) patients in a mean follow-up period of 5.3 years. The average time of recurrence was 2.5 years (range, 9-74 months). CONCLUSIONS: Conservative management could be efficacious for IGM, and less and simpler can be enough to achieve more effective results. KEY WORDS: Abscess drainage, Antibiotics Idiopathic granulomatous mastitis (IGM), Conservative management, Corticosteroids.


Assuntos
Tratamento Conservador , Mastite Granulomatosa , Corticosteroides/uso terapêutico , Adulto , Antibacterianos/uso terapêutico , Drenagem , Feminino , Mastite Granulomatosa/tratamento farmacológico , Humanos , Recidiva , Estudos Retrospectivos
5.
Ann Ital Chir ; 90: 520-523, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31541544

RESUMO

AIM: Endoscopic retrograde cholangiopancreatography (ERCP) is an important diagnostic and therapeutic tool in patients with hepato-pancreatobiliary diseases. In the present study, we sought to determine predictors of post-ERCP complications at our institution. METHODS: A retrospective analysis of patients who underwent ERCP in between January 2010 and November 2011 was done. Demographics, indications, ERCP findings, success rate, complications and the need of repeat procedure were evaluated with special emphasis on the difficulty in cannulation procedure, the primary etiology of the disease (benign/malign) and age. Chi-square analysis was applied for statistical analysis. The differences were considered statistically significant, if the p value was less than 0.05. RESULTS: A total of 112 ERCP was performed in 81 patients. Thirty-eight were male (46.9 %) and 43 were female (53.1%). Mean age was 61.3 (range 17-88), and 31 patients was seventy years and older (38.3 %). Complications were detected in 28 patients (34.6 %). Nine cases with difficult or unsuccessful cannulation (69.2 %) had complications (p=0.001). Patients with benign diseases showed less complications (21/70), in comparison with those with malignancies (7/11) (30 % vs. 63.6 %, respectively; p<0.05). Complication rate in patients 70 years and older was 32.2 % (n=10) compared to 35.3 % in patients younger than 70 (n= 18) (p<0.05). CONCLUSION: Risk factors such as difficult or incomplete cannulation and malignancy are considered as possible predisposing factors for complications. Age is an independent factor. KEY WORDS: Endoscopic cholangiopancreatography, Risk factors.


Assuntos
Colangiopancreatografia Retrógrada Endoscópica/efeitos adversos , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Doenças dos Ductos Biliares/diagnóstico , Doenças dos Ductos Biliares/cirurgia , Neoplasias dos Ductos Biliares/diagnóstico , Neoplasias dos Ductos Biliares/cirurgia , Cateterismo/efeitos adversos , Cateterismo/métodos , Feminino , Cálculos Biliares/cirurgia , Humanos , Hiperamilassemia/epidemiologia , Hiperamilassemia/etiologia , Masculino , Pessoa de Meia-Idade , Pancreatite/epidemiologia , Pancreatite/etiologia , Estudos Retrospectivos , Fatores de Risco , Centros de Cuidados de Saúde Secundários/estatística & dados numéricos , Esfinterotomia Endoscópica/efeitos adversos , Esfinterotomia Endoscópica/métodos , Adulto Jovem
6.
Ulus Travma Acil Cerrahi Derg ; 23(5): 400-404, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29052826

RESUMO

BACKGROUND: Fournier's gangrene is a surgical emergency that progresses rapidly and insidiously and results in high morbidity and mortality rates unless it is immediately diagnosed and managed. Here we analyze the outcomes of patients who were followed up and treated for Fournier's gangrene. METHODS: We conducted a retrospective analysis of the medical data of 25 patients operated on for Fournier's gangrene between January 2010 and June 2015. The diagnosis of Fournier's gangrene was made by performing a physical examination. Patients who had genital, perineal, and perianal tenderness; induration; cyanosis; gangrene; and subcutaneous crepitation were considered as having Fournier's gangrene. Following resuscitation, aggressive surgical debridement was performed and vacuum-assisted closure (VAC) was conducted in addition to debridement in select patient. Repeat debridements were performed as requirement. RESULTS: This study included 25 patients. Fourteen patients (56%) were females and 11 (44%) were males. The mean age of the patients was 54.3 years (range: 27-82 years). The mean duration of hospital stay was 21.4 days; the mean number of debridements performed was 2.4. Thirteen patients (52%) had perianal abscesses, and 20 (80%) had diabetes mellitus. All patients underwent extensive debridement; 16 patients (64%) underwent VAC in addition to debridement. Patients undergoing VAC had significantly longer durations of hospital stay and a higher mean number of debridements performed (p=0.004 and p=0.048, respectively). An ostomy was made in one patient, and one patient died. CONCLUSION: In Fournier's gangrene, early diagnosis, effective resuscitation, aggressive debridement, and VAC application in suitable cases may reduce the morbidity and mortality rates and the need for an ostomy.


Assuntos
Gangrena de Fournier , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Gangrena de Fournier/diagnóstico , Gangrena de Fournier/epidemiologia , Gangrena de Fournier/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
7.
Ulus Travma Acil Cerrahi Derg ; 23(2): 107-111, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28467575

RESUMO

BACKGROUND: Stab wounds in the left thoracoabdominal region may cause diaphragmatic injury. The aim of the present study was to determine incidence of diaphragmatic injury and role of diagnostic laparoscopy in detection of injury in patients with left thoracoabdominal stab wound. METHODS: Total of 81 patients (75 male, 6 female; mean age 27.5±9.8 years; range 14 to 60 years) who presented with left thoracoabdominal stab wound between April 2009 and September 2014 were evaluated. Laparotomy was performed on patients who had hemodynamic instability, signs of peritonitis, or organ evisceration. Remaining patients were followed conservatively. After 48 hours, diagnostic laparoscopy was performed on patients without laparotomy indication to examine the left diaphragm for injury. Follow-up and treatment findings were prospectively evaluated. RESULTS: Thirteen patients underwent laparotomy while diagnostic laparoscopy was performed on remaining 68 patients. Left diaphragmatic injury was observed in 19 patients (23.5%) in the study group. Four injuries were diagnosed by laparotomy and 15 were diagnosed by laparoscopy. Presence of hemopneumothorax did not yield difference in incidence of diaphragmatic injury (p=0.131). No significant difference was detected in terms of diaphragmatic injury with respect to entry site of stab wound in the thoracoabdominal region (p=0.929). CONCLUSION: It is important to evaluate the diaphragm in left thoracoabdominal stab injuries, and diagnostic laparoscopy is still the safest and most feasible method.


Assuntos
Traumatismos Abdominais , Diafragma , Laparoscopia , Traumatismos Torácicos , Ferimentos Perfurantes , Traumatismos Abdominais/diagnóstico , Traumatismos Abdominais/epidemiologia , Traumatismos Abdominais/cirurgia , Adolescente , Adulto , Diafragma/lesões , Diafragma/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Traumatismos Torácicos/diagnóstico , Traumatismos Torácicos/epidemiologia , Traumatismos Torácicos/cirurgia , Ferimentos Perfurantes/diagnóstico , Ferimentos Perfurantes/epidemiologia , Ferimentos Perfurantes/cirurgia , Adulto Jovem
8.
Injury ; 46(9): 1734-7, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26105131

RESUMO

INTRODUCTION: Penetrating left thoracoabdominal stab injuries are accompanied by diaphragmatic injury in 25-30% of cases, about 30% of which later develop into diaphragmatic hernia. This study aimed to determine the role of multislice computed tomography in the evaluation of left diaphragm in patients with penetrating left thoracoabdominal stab wounds. MATERIALS AND METHODS: This study reviewed penetrating left thoracoabdominal stab injuries managed in our clinic between April 2009 and September 2014. The thoracoabdominal region was defined as the region between the sternum, fourth intercostal space, and arcus costa anteriorly and the vertebra, lower tip of scapula, and the curve of the last rib posteriorly. Unstable cases and cases with signs of peritonitis were operated with laparotomy; the remaining patients were closely monitored. Forty-eight hours later, a diagnostic laparoscopy was applied to evaluate the left hemidiaphragma in asymptomatic patients who did not need laparotomy. The preoperatively obtained multislice thoracoabdominal computed tomography images were retrospectively examined for the presence of left diaphragm injury. Then, operative and tomographic findings were compared. RESULTS: This study included a total of 43 patients, 39 (91%) males and 4 (9%) females of mean age 30 years (range 15-61 years). Thirty patients had normal tomography results, whereas 13 had left diaphragmatic injuries. An injury to the left diaphragm was detected during the operation in 9 (1 in laparotomy and 8 in diagnostic laparoscopy) of 13 patients with positive tomography for left diaphragmatic injury and 2 (in diagnostic laparoscopy) of 30 patients with negative tomography. Multislice tomography had a sensitivity of 82% (95% CI: 48-98%), a specificity of 88% (71-96%), a positive predictive value of 69% (39-91%), and a negative predictive value of 93% (78-99%) for detection of diaphragmatic injury in penetrating left thoracoabdominal stab injury. CONCLUSIONS: Although diagnostic laparoscopy is the gold standard for diaphragmatic examination in patients with penetrating left thoracoabdominal stab wounds, multislice computed tomography is also valuable for detecting diaphragmatic injury.


Assuntos
Traumatismos Abdominais/diagnóstico por imagem , Diafragma/lesões , Tomografia Computadorizada Multidetectores , Peritonite/patologia , Traumatismos Torácicos/diagnóstico por imagem , Ferimentos Perfurantes/diagnóstico por imagem , Traumatismos Abdominais/complicações , Traumatismos Abdominais/mortalidade , Adolescente , Adulto , Feminino , Humanos , Laparoscopia/métodos , Laparotomia/métodos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada Multidetectores/métodos , Peritonite/etiologia , Peritonite/mortalidade , Guias de Prática Clínica como Assunto , Estudos Retrospectivos , Traumatismos Torácicos/complicações , Traumatismos Torácicos/mortalidade , Turquia/epidemiologia , Ferimentos Perfurantes/complicações , Ferimentos Perfurantes/mortalidade
9.
J Obstet Gynaecol Res ; 38(3): 526-30, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22381104

RESUMO

AIM: The abdominal wall is an uncommon site of extrapelvic endometriosis. It usually develops in a previous surgical scar and should be considered in the differential diagnosis of any abdominal swelling. Classical symptoms of endometriosis may resemble abdominal wall lesions such as an incisional hernia, hematoma, granuloma, abscess or various soft tissue tumors; therefore, a definitive preoperative diagnosis is not always easy to determine in every case. The aim of this article is to review the clinical findings, imaging results and histopathology of those of our patients who have had cesarean scar endometriosis. METHODS: Patients diagnosed with abdominal wall endometriosis in their surgical scars from February 2008 to March 2010 were documented. The age, parity, symptoms, previous surgeries, initial diagnosis, diagnostic modalities, definitive operation, postoperative complications, histopathological evaluations and recurrences were recorded and analyzed. RESULTS: There were 18 patients with a mean age of 34.5 ± 9.6 years. All (100%) had a gradually growing nodular abdominal mass in or adjacent to their cesarean incision scars. This was often associated with pain (83.3%), either noncyclical (26.6%) or cyclical (73.3%) in nature. Ultrasonography (100%), computerized tomography with intravenous contrast (22.2%) and/or magnetic resonance imaging (66.6%) were performed on the patients. All patients underwent surgery and their masses were completely excised. The mean diameter of the removed masses was 3.9 ± 1.4 cm. The final pathological diagnosis for each case was abdominal wall endometriosis. Biannual follow-up examinations for two years revealed that each patient had a complete and uneventful recovery without recurrence. CONCLUSION: Abdominal wall endometriosis should be considered in the differential diagnosis of masses located at cesarean section incision scars, which should be excised for definitive diagnosis and treatment.


Assuntos
Parede Abdominal/patologia , Cesárea , Cicatriz/patologia , Endometriose/diagnóstico , Complicações Pós-Operatórias/diagnóstico , Adulto , Diagnóstico Diferencial , Endometriose/etiologia , Endometriose/cirurgia , Feminino , Seguimentos , Humanos , Complicações Pós-Operatórias/cirurgia , Recidiva , Resultado do Tratamento
10.
Surg Today ; 42(8): 729-33, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22068681

RESUMO

PURPOSE: Granulomatous mastitis (GM) is a rare benign inflammatory breast disease. The clinical presentation of granulomatous mastitis usually mimics malignancy or infection. The aim of this study was to review the clinical and diagnostic features of GM and discuss the medical and surgical treatment of our series of eight GM patients. METHODS: Between 2008 and 2010, eight patients were diagnosed with GM and underwent surgery. Patients were evaluated clinically and radiologically. The diagnosis of GM was confirmed in all cases by core needle or excisional biopsies. Serological tests were performed for rheumatoid factor (RF), antinuclear antibody (ANA), and anti-double-stranded DNA (anti-dsDNA). RESULTS: The mean patient age was 37 years. Common presenting symptoms were a hard mass, pain, inflamed hyperemic skin, and sinus formation. Serological tests for RF were positive in 6 patients, and ANA and anti-dsDNA antibodies were detected in 2 patients. All patients underwent antibiotic therapy before surgery, and were treated with wide surgical excision with negative margins. Methylprednisolone (16 mg/day for 3 months) therapy was used in 3 patients (all RF and 2 ANA/anti-dsDNA positive) following a wide excisional biopsy after a postoperative recurrence mimicking skin lesions was seen. These patients responded well to steroid therapy. CONCLUSIONS: The diagnosis of GM should be made carefully to avoid a misdiagnosis. Steroid therapy should be considered based on the idea that this is an autoimmune disease.


Assuntos
Mastite Granulomatosa , Adulto , Antibacterianos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Anticorpos Antinucleares/sangue , Biomarcadores/sangue , Biópsia , Mama/patologia , Mama/cirurgia , Terapia Combinada , Feminino , Seguimentos , Mastite Granulomatosa/diagnóstico , Mastite Granulomatosa/tratamento farmacológico , Mastite Granulomatosa/imunologia , Mastite Granulomatosa/cirurgia , Humanos , Imageamento por Ressonância Magnética , Mamografia , Metilprednisolona/uso terapêutico , Pessoa de Meia-Idade , Fator Reumatoide/sangue , Resultado do Tratamento , Ultrassonografia Mamária
11.
Exp Clin Transplant ; 9(5): 344-8, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21967263

RESUMO

Hemangioma is the most common benign tumor of the liver. Unlike cavernous hemangioma, hepatic capillary or mixed capillary-cavernous hemangioma is a rare type of tumor in adults. Clinical presentation of hemangioma may mimic that of hepatocellular carcinoma. Furthermore, radiologic features on computed tomography and magnetic resonance imaging may not be typical for hemangioma and can be confused with hepatocellular carcinoma. Symptomatic hemangiomas require some form of treatment, such as corticosteroids, interferon, radiation, arterial embolization, surgical resection, or liver transplant. In the present case study, we present a patient treated with liver transplant for hemangioma mimicking hepatocellular carcinoma. This case report illustrates the atypical imaging appearance of hemangioma and possible confusion it can cause in diagnosing hepatocellular carcinoma, especially in a hepatitis C carrier.


Assuntos
Carcinoma Hepatocelular/diagnóstico , Erros de Diagnóstico , Hemangioma Capilar/cirurgia , Hemangioma Cavernoso/cirurgia , Neoplasias Hepáticas/cirurgia , Transplante de Fígado , Biópsia , Feminino , Hemangioma Capilar/diagnóstico , Hemangioma Capilar/patologia , Hemangioma Cavernoso/diagnóstico , Hemangioma Cavernoso/patologia , Hepatite C/diagnóstico , Humanos , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/patologia , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Tomografia Computadorizada por Raios X , Resultado do Tratamento
12.
Eur J Obstet Gynecol Reprod Biol ; 159(1): 87-90, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21831513

RESUMO

OBJECTIVES: The obstetrician often has a difficult task in diagnosing and managing the acute abdomen in pregnancy. A reluctance to operate during pregnancy adds unnecessary delay, which may increase morbidity for both mother and fetus. In this study, we present our experience in pregnant patients with acute abdomen. STUDY DESIGN: Pregnant patients with acute abdomen requiring surgical exploration were enrolled from 2007 to 2010. Demographics, gestational age, symptoms, fetal loss, preterm delivery, imaging studies, operative results, postoperative complications and histopathologic evaluations were recorded. Ultrasound (US) and magnetic resonance (MR) imaging studies were evaluated. Data analyses were performed with Microsoft Excel and statistical evaluations were done by using Student's t-test. RESULTS: There were 20 patients with a mean age of 32 years. The rate of emergency surgery was seen to be significantly higher in the second trimester (p<0.05). Most common symptoms were abdominal pain (100%) and nausea (80%). US was done in all patients while MR imaging was used in 30%. However, US findings were consistent with surgical findings in only 55%, while MR was successful in assigning the correct diagnosis in 83.3%. Appendicitis and adhesive small bowel obstruction were the most common etiologies causing acute abdomen (30% and 15%, respectively). All patients tolerated surgery well, and postoperative complications included wound infection, 10%, preterm labor, 5%, and prolonged paralytic ileus, 5%. One patient died from advanced gastric carcinoma and the only fetal death was seen in this case. CONCLUSIONS: Prompt diagnosis and appropriate therapy are crucial in pregnant with acute abdomen. The use of US may be limited and CT is not desirable due to fetal irradiation. MR has thus become increasingly popular in the evaluation of such patients. Adhesive small bowel obstruction should be kept in mind as an important etiology.


Assuntos
Abdome Agudo/cirurgia , Complicações na Gravidez/cirurgia , Abdome Agudo/diagnóstico , Adulto , Apendicite/diagnóstico , Apendicite/cirurgia , Feminino , Humanos , Obstrução Intestinal/diagnóstico , Obstrução Intestinal/cirurgia , Intestino Delgado/cirurgia , Imageamento por Ressonância Magnética , Gravidez , Complicações na Gravidez/diagnóstico , Resultado do Tratamento , Adulto Jovem
13.
Biol Trace Elem Res ; 124(2): 135-43, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18408897

RESUMO

It has been previously shown that alcohol induces the damage of pancreatic parenchyma tissue, but the mechanism of this damage is still poorly understood. Assuming that oxygen radical damage may be the involved, we measured markers of oxidative damage in pancreatic tissue, blood serum, plasma, and whole blood of rats with early-stage alcohol-induced acute pancreatitis. Thirty-eight male Wistar rats were divided into three groups: the control group (group 1), the acute pancreatitis group 1 day (group 2), and 3 days (group 3) after the injection of ethyl alcohol into the common biliary duct, respectively. The levels of Fe in tissue and serum, whole blood viscosity, plasma viscosity, fibrinogen and homocysteine (Hcy) levels, erythrocyte and plasma malondialdehyde (MDA), and tissue and plasma protein carbonyl levels were found to be significantly higher in groups 2 and 3 than in group 1. However, the levels of reduced glutathione (GSH) in tissue and erythrocytes were significantly lower in groups 2 and 3 than in group 1. These results suggest that elevated Fe levels in serum and pancreatic tissue in rats with early-stage alcohol-induced acute pancreatitis is associated with various hemorheological changes and with oxidative damage of the pancreas.


Assuntos
Depressores do Sistema Nervoso Central/toxicidade , Etanol/toxicidade , Ferro/sangue , Peroxidação de Lipídeos/efeitos dos fármacos , Pancreatite Alcoólica/sangue , Carbonilação Proteica/efeitos dos fármacos , Doença Aguda , Animais , Viscosidade Sanguínea/efeitos dos fármacos , Eritrócitos/metabolismo , Fibrinogênio/análise , Glutationa/sangue , Homocisteína/sangue , Masculino , Malondialdeído/sangue , Oxirredução , Pâncreas/metabolismo , Pancreatite Alcoólica/induzido quimicamente , Ratos , Ratos Wistar
16.
Surg Laparosc Endosc Percutan Tech ; 15(6): 371-3, 2005 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16340573

RESUMO

Torsion of the appendices epiploicae is a rare condition that may present with acute abdominal pain and mimics appendicitis. We report a 20-year-old previously appendectomized man presenting with right lower abdominal quadrant pain. Abdominal ultrasonography showed a localized omental thickening in the right paracolic region. Contrast-enhanced computed tomography revealed well-circumscribed fatty tissue adjacent to the cecum with heterogeneous hyperdense infiltration of the mesentery near the sigmoid colon. Diagnostic laparoscopy revealed 2-cm diameter torsioned and edematous fatty tissue floating on the omentum in the right lower quadrant. The torsioned mass was elevated, and a thick stalk was seen to be connecting the fatty tissue to the sigmoid colon. At this point, the torsioned fatty tissue was considered as a sigmoidal appendix epiploica that was elongated and neighboring on the previously operated-on region. The lesion was removed by laparoscopic means using 3 ports. Grossly, fat necrosis and internal bleeding were seen. Histopathologic analysis of the resected tissue demonstrated adipose tissue surrounded by fibrotic inflammatory changes with marked infiltration of numerous lymphocytes and histiocytes. In conclusion, torsion of appendices epiploicae should be included in the differential diagnosis of acute abdomen when evaluating patients with right lower quadrant pain and a history of appendectomy. Laparoscopic surgery provides definite diagnosis and prevents unnecessary open procedures for such lesions leading to peritoneal irritation.


Assuntos
Apendicectomia/efeitos adversos , Colectomia/métodos , Laparoscopia , Doenças do Colo Sigmoide/cirurgia , Adulto , Diagnóstico Diferencial , Seguimentos , Humanos , Masculino , Doenças do Colo Sigmoide/diagnóstico , Doenças do Colo Sigmoide/etiologia , Anormalidade Torcional
17.
Biol Trace Elem Res ; 106(3): 205-9, 2005 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16141468

RESUMO

Serum free prostate-specific antigen (fPSA) is the most useful tumor marker for prostatic cancer screening. However, recently, fPSA has also been detected in sera from patients with pancreatic diseases. In addition, it has been shown that zinc (Zn) concentration might change in both serum and tissues in pancreatic disease. In the present study, we measured serum concentrations of fPSA and Zn as possible markers and prognostic factors in an experimental acute-pancreatitis model. Twenty-five female Wistar albino rats were divided into two groups: the control group (n=10) and the experimental group (n=15). Acute pancreatitis was induced by injection of ethyl alcohol into the common biliary duct. The animals were sacrificed 24 h later to detect the concentrations of serum fPSA and Zn. fPSA values were detected to be significantly higher in the experimental group (p < 0.001). There was also a significant decrease in the serum Zn level of the acute-pancreatitis group (p < 0.001). In conclusion, these findings suggested that a combination of these parameters might represent a significant improvement on the diagnostic value of each of them separately and provide a powerful tool for differential diagnosis and prognosis in pancreatic diseases.


Assuntos
Biomarcadores/sangue , Pancreatite/fisiopatologia , Antígeno Prostático Específico/sangue , Zinco/sangue , Doença Aguda , Animais , Diagnóstico Diferencial , Etanol/toxicidade , Feminino , Pancreatite/diagnóstico , Pancreatite/veterinária , Prognóstico , Ratos , Ratos Wistar , Solventes/toxicidade
18.
World J Gastroenterol ; 11(15): 2340-5, 2005 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-15818750

RESUMO

AIM: Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP). Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation. METHODS: AP was induced in rats (n = 25) by injection of ethyl alcohol into the common biliary duct. A sham laparatomy was performed in controls (n = 15). After 24 h the animals were killed, blood and tissue sampling were done. RESULTS: Histopathologic evidence confirmed the development of AP. Marked changes were observed in the pulmonary tissue. Compared with controls, the AP group displayed higher values for NO metabolites in pancreas and lungs, and thiobarbituric acid reactive substances in circulation. Glutathione was lower in pancreas and in circulation. Glutathione and NO were positively correlated in pancreas and lungs of controls but negatively correlated in circulation of experimental group. In the experimental group, plasma thiobarbituric acid reactive substances were negatively correlated with pancreas thiobarbituric acid reactive substances but positively correlated with pancreas NO. CONCLUSION: NO increases in both pancreas and lungs in AP and NO contributes to the pathogenesis of AP under oxidative stress.


Assuntos
Alcoolismo/metabolismo , Óxido Nítrico/metabolismo , Estresse Oxidativo/fisiologia , Pancreatite/metabolismo , Doença Aguda , Alcoolismo/complicações , Alcoolismo/patologia , Animais , Glutationa/metabolismo , Pancreatite/etiologia , Pancreatite/patologia , Ratos , Ratos Wistar , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
19.
Surg Laparosc Endosc Percutan Tech ; 14(5): 247-9, 2004 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-15492650

RESUMO

The present study was designed to examine the effect of intra-abdominal pressure level on gastric intramucosal pH using gastric tonometry during pneumoperitoneum. One hundred patients were prospectively randomized into 5 equal groups (N = 20 each). Intra-abdominal pressure levels were 8, 10, 12, 14, and 16 mm Hg in groups I, II, III, IV, and V, respectively. Intramucosal pH measurement was done 2 times: 30 minutes following insufflation and 1 hour after the ending of the surgery. In the first and second measurements, intramucosal pH values were found as 7.39 +/- 0.02 and 7.36 +/- 0.03 in group I; 7.41 +/- 0.03 and 7.38 +/- 0.03 in group II; 7.37 +/- 0.03 and 7.37 +/- 0.03 in group III; 7.36 +/- 0.03 and 7.37 +/- 0.03 in group IV; and 7.39 +/- 0.03, 7.36 +/- 0.03 in group V, respectively. Statistical significance was not found in the comparison of these values within the groups and between the groups (P > 0.005, for each). In conclusion, intra-abdominal pressure between 8 and 16 mm Hg did not cause significant difference in gastric intramucosal pH.


Assuntos
Cavidade Abdominal/fisiologia , Mucosa Gástrica/fisiologia , Pneumoperitônio/fisiopatologia , Pressão/efeitos adversos , Adulto , Colecistectomia Laparoscópica , Feminino , Humanos , Concentração de Íons de Hidrogênio , Masculino , Pessoa de Meia-Idade
20.
J Laparoendosc Adv Surg Tech A ; 14(4): 241-3, 2004 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-15345165

RESUMO

We report the case of a patient who underwent laparoscopic removal of a retained surgical spatula two months after a total abdominal hysterectomy and bilateral salpingo-oophorectomy for endometrial carcinoma. The foreign body was detected on a routine radiograph while the patient was been prepared for radiotherapy. Laparoscopy allowed us to explore the entire abdominal cavity for any potential complications of the retained instrument, and the procedure was completed successfully. This case demonstrates the feasibility of using a minimally invasive technique in the removal of a retained foreign body.


Assuntos
Abdome , Corpos Estranhos/cirurgia , Laparoscopia , Instrumentos Cirúrgicos , Neoplasias do Endométrio/cirurgia , Feminino , Corpos Estranhos/diagnóstico por imagem , Humanos , Histerectomia , Pessoa de Meia-Idade , Ovariectomia , Radiografia
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