RESUMO
Acquired reactive perforating collagenosis (ARPC) is an uncommon dermatosis characterized by transepidermal elimination of altered collagen. It is commonly seen in patients with diabetes mellitus and/or chronic renal insufficiency. Rarely, it has been reported in association with malignancy and other conditions. We report a 30-year-old woman with insulin-dependent diabetes mellitus who presented with multiple, discrete, violaceous, hyperkeratotic papules on the extensor aspects of both legs, characteristic of ARPC. Four months later, metastatic papillary thyroid cancer was diagnosed. This case further supports the possibility that ARPC may represent a paraneoplastic phenomenon.
Assuntos
Carcinoma Papilar/complicações , Doenças do Colágeno/etiologia , Diabetes Mellitus Tipo 1/complicações , Síndromes Paraneoplásicas/etiologia , Neoplasias da Glândula Tireoide/complicações , Adulto , Idoso , Doenças do Colágeno/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Síndromes Paraneoplásicas/patologiaRESUMO
Majocchi's granuloma, also known as nodular granulomatous perifolliculitis, is an uncommon fungal infection of the skin and subcutaneous tissue. It can occur in healthy and immunocompromised patients. The most common cause of Majocchi's granuloma is Trichophyton rubrum. We report a case of a Majocchi's granuloma caused by Aspergillus fumigatus in a patient with acquired immunodeficiency syndrome.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS/microbiologia , Aspergilose/microbiologia , Aspergillus fumigatus/isolamento & purificação , Dermatomicoses/microbiologia , Granuloma/microbiologia , Adulto , Contagem de Linfócito CD4 , Evolução Fatal , Humanos , Hospedeiro Imunocomprometido , MasculinoRESUMO
Botryomycosis is an uncommon, chronic, granulomatous and/or suppurative, opportunistic infection affecting the skin and viscera, primarily caused by bacteria. The exact pathogenesis of this infection is not well understood. However, both the host's immune status and microbial infectivity have been implicated in the pathogenesis of this unusual clinical condition. To date, botryomycosis caused by a nonbacterial pathogen has not been reported in the literature. We report a case of cutaneous botryomycosis caused by combined Staphylococcus aureus and Pneumocystis carinii. Cutaneous P. carinii infection without pulmonary involvement is extremely rare.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS/microbiologia , Dermatomicoses/microbiologia , Infecções por Pneumocystis/microbiologia , Infecções Cutâneas Estafilocócicas/microbiologia , Infecções Oportunistas Relacionadas com a AIDS/patologia , Contagem de Linfócito CD4 , Dermatomicoses/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Infecções por Pneumocystis/patologia , Pneumocystis carinii , Infecções Cutâneas Estafilocócicas/patologia , Staphylococcus aureusRESUMO
Extranodal Hodgkin disease presenting as a primary localized neoplasm is uncommon, with rare case reports describing primary sites other than lymph nodes. The gastrointestinal tract is the most frequent site of involvement by extranodal Hodgkin disease, typically involving the stomach or small bowel. To date, we have been able to find only one fully documented case of Hodgkin disease of the sigmoid colon confirmed by immunohistochemical studies. We report a case of extranodal Hodgkin disease involving the transverse colon, presenting as inflammatory bowel disease and documented by light microscopic, immunohistochemical, cytogenetic, and molecular studies.
Assuntos
Neoplasias do Colo/patologia , Doença de Hodgkin/patologia , Adulto , Neoplasias do Colo/metabolismo , Feminino , Doença de Hodgkin/metabolismo , Humanos , Imuno-Histoquímica , Antígeno Ki-1/análise , Antígenos CD15/análise , Vimentina/análiseRESUMO
OBJECTIVE: Carcinosarcomas of urinary bladder are rare malignant neoplasms. Seventy-eight cases have been previously described. The histologic composition of these tumors is variable, but diagnosis requires the presence of both epithelial and mesenchymal malignant components. We report 4 additional cases, with an emphasis on unusual histologic features. METHODS: Histologic and immunohistochemical examinations were performed on bladder tumors from 4 patients. Clinicopathologic features of previously reported and current cases were reviewed and summarized. RESULTS: Four patients (3 men, 1 woman) age 54 to 77 years were found to have polypoid masses in the urinary bladder. In all cases, histologic examination showed biphasic neoplasms with distinct mesenchymal and epithelial components. The morphologic and immunohistochemical characteristics of the tumors varied. One of the cases was remarkable for the presence of liposarcoma, malignant peripheral nerve sheath tumor, and micropapillary urothelial carcinoma. Two of the patients died 2 years after diagnosis, which is consistent with the previously reported aggressive nature of urinary bladder carcinosarcomas. CONCLUSIONS: Carcinosarcomas of the urinary bladder are rare, aggressive malignant neoplasms. To our knowledge, a liposarcomatous component has been reported in only 1 case previously, and components of micropapillary urothelial carcinoma and malignant peripheral nerve sheath tumor have not been reported previously in carcinosarcomas of the urinary bladder. Because of the aggressive biologic behavior of these tumors, they should be identified promptly and treated appropriately.
Assuntos
Carcinoma de Células de Transição/patologia , Carcinossarcoma/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias da Bexiga Urinária/patologia , Idoso , Carcinoma de Células de Transição/cirurgia , Carcinossarcoma/cirurgia , Diagnóstico Diferencial , Evolução Fatal , Feminino , Humanos , Imuno-Histoquímica , Lipossarcoma/patologia , Lipossarcoma/cirurgia , Masculino , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/cirurgia , Neoplasias de Bainha Neural/patologia , Neoplasias de Bainha Neural/cirurgia , Neoplasias da Bexiga Urinária/cirurgiaRESUMO
OBJECTIVE: To prospectively review brush smears obtained during endoscopic retrograde cholangiopancreatography (ERCP) primarily from the biliary tree. STUDY DESIGN: A total of 175 specimens from 147 patients were included in the study. The smears, prepared directly from the endoscopic brush, were stained by the Papanicolaou technique and analyzed for standard cytologic features. RESULTS: The smears were categorized into benign/reactive, significant atypia and suspicious/positive. The consistent features seen in suspicious or positive smears were tightly cohesive, small, three-dimensional cell clusters that formed cell balls. The cells in the clusters displayed features of malignant cells. CONCLUSION: ERCP-guided brushing is a safe diagnostic procedure for the evaluation of biliary tree lesions. Small, three-dimensional epithelial clusters with marked atypia signify malignancy and warrant the diagnosis of a malignant neoplasm even when only one or two such clusters are seen in the smears. Single cells, cytoplasmic vacuoles and prominent nucleoli are not essential for a diagnosis of malignancy.
Assuntos
Doenças Biliares/diagnóstico , Doenças Biliares/patologia , Sistema Biliar/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Colangiopancreatografia Retrógrada Endoscópica , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
We report of a solitary fibrous tumor (SFT) of the vagina and discuss the differential diagnosis. This is the first SFT documented, to our knowledge. SFTs should be included in the differential diagnosis of fibroblastic, myofibroblastic, and neural lesions of the skin, subcutaneous tissue, and mucosa and can be distinguished from other spindle cell neoplasms at those sites.
Assuntos
Neoplasias Vaginais/patologia , Idoso , Diagnóstico Diferencial , Feminino , Fibroma/química , Fibroma/patologia , Humanos , Imuno-Histoquímica , Mesotelioma/química , Mesotelioma/patologia , Neoplasias Vaginais/químicaRESUMO
We report a case of inflammatory myofibroblastic tumor (IMF) of the skin in a female with a history of Wegeners granulomatosis. The patient had a painless, erythematous, and indurated lesion of the left elbow. The resected specimen revealed a 4 cm x 3 cm nodule involving the entire dermis and superficial portions of subcutis with a stellate profile at scanning magnification. There were spindle cells in fascicles and whorls and a mixed inflammatory cell infiltrate of plasma cells, lymphocytes, neutrophils, and eosinophils. The spindle cells were immunoreactive for vimentin, muscle specific actin, and smooth muscle actin. The polyclonal and polymorphous nature of the inflammatory cells was confirmed by immunohistochemical studies. This is the first case of IMF of the skin documented by immunostaining.
Assuntos
Granuloma de Células Plasmáticas/patologia , Dermatopatias/patologia , Actinas/análise , Antígenos CD20/análise , Complexo CD3/análise , Antígenos CD4/análise , Feminino , Granuloma de Células Plasmáticas/metabolismo , Humanos , Imuno-Histoquímica , Antígeno Ki-1/análise , Pessoa de Meia-Idade , Músculos/metabolismo , Proteínas S100/análise , Pele/química , Pele/patologia , Dermatopatias/metabolismo , Vimentina/análiseRESUMO
A case of mycormycosis presenting primarily as a subcutaneous mass of the left leg in an immunocompetent individual is described. The mass that was diagnosed initially as a non-specific foreign body granulomatous process recurred a year later. Histopathological examination of the primary and recurrent lesions revealed partly degenerated hyphae associated with acute necrotizing and chronic granulomatous inflammation. Histomorphological features of primary subcutaneous mucormycosis without predisposing factors have not been previously reported.
Assuntos
Dermatomicoses/diagnóstico , Mucormicose/diagnóstico , Idoso , Anfotericina B/uso terapêutico , Antifúngicos/uso terapêutico , Desbridamento , Dermatomicoses/microbiologia , Dermatomicoses/patologia , Dermatomicoses/terapia , Humanos , Imunocompetência/fisiologia , Perna (Membro) , Masculino , Mucor/isolamento & purificação , Mucormicose/microbiologia , Mucormicose/patologia , Mucormicose/terapia , RecidivaRESUMO
Echocardiographic examination, performed in an asymptomatic 5 year old boy for a perimembranous ventricular septal defect (VSD), revealed a 6 x 6 mm tumor on the anterior leaflet of the mitral valve. Clinically, it was diagnosed as a benign myxoma. Histopathologic diagnosis of the excised mitral valve tumor was benign lipoma. The third case of mitral valve lipoma in the pediatric age group is reported along with a review of the literature. Echocardiogram remains the most sensitive diagnostic modality in the early detection of such neoplasms.
Assuntos
Neoplasias Cardíacas/patologia , Doenças das Valvas Cardíacas/patologia , Lipoma/patologia , Valva Mitral/patologia , Adipócitos/patologia , Pré-Escolar , Histocitoquímica , Humanos , MasculinoRESUMO
BACKGROUND: Primary effusion lymphoma (PEL), commonly described in AIDS patients, is a unique subset of lymphoma in which the neoplastic lymphocytes proliferate exclusively in serous cavities. CASE: A 27-year-old male, HIV positive for five years and with multiple opportunistic infections in the past, was admitted for sudden-onset shortness of breath caused by a pleural effusion. Cytologic examination of the pleural fluid revealed medium to large atypical lymphocytes with a high mitosis rate, suspicious for lymphoma. Further diagnostic tests, such as immunophenotypic analysis and cytogenetic and molecular studies, confirmed the diagnosis of PEL. CONCLUSION: Cytopathologists and cytotechnologists should be aware of this new entity since additional studies are required for a definitive diagnosis.
Assuntos
Linfoma Relacionado a AIDS/patologia , Derrame Pleural Maligno/patologia , Adulto , Citodiagnóstico/métodos , Citometria de Fluxo , Humanos , Linfoma Relacionado a AIDS/diagnóstico , Linfoma Relacionado a AIDS/imunologia , Linfoma Relacionado a AIDS/virologia , Masculino , Derrame Pleural Maligno/diagnóstico , Derrame Pleural Maligno/imunologia , Derrame Pleural Maligno/virologiaRESUMO
Juxtaoral organs known as organs of Chievitz are intramuscular embryonic structures found close to the angle of the mandible near the insertion of the pterygomandibular raphae. They are considered of neuroepithelial origin with no known function. We describe the first tumor of the organ of Chievitz which presented intraorally in a child. Immunohistochemically, the Chievitz nests showed positive reaction for vimentin, cytokeratins, and epithelial membrane antigen and ultrastructurally demonstrated cytoplasmic processes and intermediate filament bundles. These observations, together with light microscopic features, suggest that the epithelial nests of the organ of Chievitz are meningothelial rather than neuroepithelial.
Assuntos
Neoplasias Bucais/patologia , Tumores Neuroectodérmicos Primitivos Periféricos/patologia , Antígenos de Neoplasias/análise , Criança , Células Epiteliais/química , Células Epiteliais/patologia , Feminino , Humanos , Microscopia Eletrônica , Neoplasias Bucais/química , Neoplasias Bucais/ultraestrutura , Tumores Neuroectodérmicos Primitivos Periféricos/química , Tumores Neuroectodérmicos Primitivos Periféricos/ultraestruturaRESUMO
Struma ovarii are specialized teratomas consisting of thyroid tissue. They may demonstrate all pathologic features seen in the thyroid gland. Malignant transformation of thyroid tissue in struma ovarii is uncommon and is rarely recurrent or metastatic. We report the diagnosis and treatment of a recurrent struma ovarii with malignant transformation, and intraperitoneal, retroperitoneal, and hepatic metastases.
Assuntos
Neoplasias Ovarianas , Estruma Ovariano , Feminino , Humanos , Pessoa de Meia-Idade , Metástase Neoplásica , Recidiva Local de Neoplasia , Neoplasias Ovarianas/diagnóstico , Neoplasias Ovarianas/terapia , Estruma Ovariano/diagnóstico , Estruma Ovariano/secundário , Estruma Ovariano/terapiaRESUMO
Primary adenocarcinoma of the fallopian tube is a rare malignant neoplasm of the female reproductive system. Unusual patterns of metastasis may be observed. Report is made of a patient with recurrent adenocarcinoma of the fallopian tube, which presented as leptomeningeal carcinomatosis, as a first site of distant metastasis three years after initial diagnosis. The diagnosis was made by cytologic examination of the cerebrospinal fluid. No other sites of distant metastasis were present.