Bioprofiling over grid for eHealthcare.

A trend in modern medicine is towards individualization of healthcare and, potentially, grid computing can play an important role in this by allowing sharing of resources and expertise to improve the quality of care. In this paper, we present a new test bed, the BIOPATTERN Grid, which aims to fulfil this role in the long term. The main objectives in this paper are 1) to report the development of the BIOPATTERN Grid, for biopattern analysis and bioprofiling in support of individualization of healthcare. The BIOPATTERN Grid is designed to facilitate secure and seamless sharing of geographically distributed bioprofile databases and to support the analysis of bioprofiles to combat major diseases such as brain diseases and cancer within a major EU project, BIOPATTERN (www.biopattern.org); 2) to illustrate how the BIOPATTERN Grid could be used for biopattern analysis and bioprofiling for early detection of dementia and for brain injury assessment on an individual basis. We highlight important issues that would arise from the mobility of citizens in the EU, such as those associated with access to medical data, ethical and security; and 3) to describe two grid services which aim to integrate BIOPATTERN Grid with existing grid projects on crawling service and remote data acquisition which is necessary to underpin the use of the test bed for biopattern analysis and bioprofiling.

Correlation between EEG and heart rate variation in deep enflurane anaesthesia.

Variations in heart rate during deep enflurane anaesthesia were studied in 11 women admitted for elective surgery. Correlation was found between heart rate variations and bursts and suppressions in the EEG patterns. The onset of bursts coincided with accelerating heart rate, and the onset of suppressions was combined with a fall in heart rate in all patients. The correlation is not explained by ventilation arrhythmia. Both the cortical electrical activity and heart rate fluctuation are probably controlled by the same subcortical factor.