Victimization and risk factors in children and adolescents admitted into outpatient protection center in northern Chile

The present study aimed to identify the proportion of victimization, types of victimization, and risk factors associated to children and adolescents who were admitted into an outpatient protection center for children and adolescents in northern Chile during the years 2016 and 2017. Secondary data from the database pertaining to the protection center was used. The sample was non-probabilistic and included 6,499 cases. The research was descriptive-comparative with a non-experimental retrospective cross-sectional design. The results showed a higher percentage of victimization by neglect, followed by witnessing domestic violence and child sexual abuse. The sociodemographic variables showed a higher percentage of victimization at the age of 6 to 9 and 14 to 17 years old, in children and adolescents who were in the first and second cycle of elementary school and were Chilean. It was found that children victimized by child sexual abuse and bullying also had a drug diagnosis record. Logistic regression analyses showed that gender, age, schooling, nationality, and a drug diagnosis record increase the probability of occurrence of certain types of victimization. The results showed the magnitude of the problem concerning victimizations experienced by children and adolescents in northern Chile and the need to generate prevention strategies for this population.

El presente estudio tuvo como objetivo identificar la proporción de victimización, tipos de victimización y factores de riesgo asociados a los niños, niñas y adolescentes que ingresaron a un Centro de Protección a la infancia en el norte de Chile durante los años 2016 y 2017. Se utilizaron datos secundarios de la base de datos del sistema de protección a la infancia. La muestra fue no probabilística e incluyó 6.499 casos. La investigación fue descriptiva-comparativa con un diseño no experimental retrospectivo de corte transversal. Los resultados mostraron un mayor porcentaje de victimización por negligencia, seguido por presenciar violencia doméstica y abuso sexual infantil. Las variables sociodemográficas mostraron un mayor porcentaje de victimización en la edad de 6 a 9 y de 14 a 17 años, en niños y adolescentes que cursaban el primer y segundo ciclo de primaria y eran chilenos. Se encontró que los niños víctimas de abuso sexual infantil y bullying también tenían un registro de diagnóstico de drogas. Los análisis de regresión logística mostraron que el género, la edad, la escolaridad, la nacionalidad y un registro de diagnóstico de drogas aumentan la probabilidad de ocurrencia de ciertos tipos de victimización. Los resultados evidencian la magnitud del problema de las victimizaciones que sufren los niños, niñas y adolescentes del norte de Chile y la necesidad de generar estrategias de prevención para esta población.

Fenomenología de la angustia moral: implicancias para la humanización de la educación y la práctica médica / Phenomenology of moral distress: implications for the humanization of medical education and practice

En el contexto de la salud, la angustia moral (AM) se refiere a las emociones negativas que surgen cuando una persona conoce el curso de acción correcto en una situación determinada pero no es capaz de seguirlo debido a impedimentos personales, jerárquicos o institucionales. La AM se ha relacionado con diversos problemas profesionales, tales como desorientación vocacional, baja motivación laboral, trato despersonalizado a los pacientes, abandono de funciones y cambios de especialidad o profesión. Si bien este fenómeno no ha sido suficientemente estudiado en Chile, se asume que existe e incluso habría aumentado durante la pandemia de COVID-19, siendo desconocidas sus repercusiones. En consecuencia, este artículo tiene como objetivos, en primer lugar, promover el estudio fenomenológico de la AM en nuestro país, considerando la importancia de prevenir su potencial impacto adverso en la salud mental de futuros profesionales, y, en segundo lugar, destacar la necesidad de incluir enfoques narrativos en la educación médica, a fin de desarrollar una aproximación más holística hacia la comprensión de los pacientes y de su condición de vulnerabilidad. En última instancia, se espera que el abordaje de las implicancias de la AM en la educación y la práctica médica contribuya con su humanización, optimizando la calidad de la atención en salud.

In the healthcare context, moral distress (MD) refers to the negative emotions that arise when a person knows the correct course of action in a given situation but is not able to follow it due to personal, hierarchical or institutional impediments. MD has been related to various professional problems, such as vocational disorientation, low work motivation, depersonalized treatment of patients, abandonment of duties, and changes of specialty or profession. Although this phenomenon has not been sufficiently studied in Chile, it presumably exists and would have even increased during the COVID-19 pandemic, leaving its repercussions unknown. Accordingly, this article has the objectives, firstly, to promote the phenomenological study of MD in our country, considering the importance of preventing its potential adverse impact on the mental health of future professionals, and, secondly, to highlight the need to include narrative approaches in medical education, in order to develop a more holistic approach to understanding patients and their condition of vulnerability. Ultimately, it is expected that addressing the implications of MD in medical education and practice will contribute to its humanization, optimizing the quality of healthcare.

Non-pharmacological prevention of postoperative delirium by occupational therapy teams: A randomized clinical trial.

Background: Patients who develop postoperative delirium (POD) have several clinical complications, such as increased morbidity, increased hospital stays, higher hospital costs, cognitive and functional impairment, and higher mortality. POD is a clinical condition preventable by standard non-pharmacological measures An intensive Occupational Therapy (OT) intervention has been shown to be highly effective in preventing delirium in critically ill medical patients, but it is unknown the effect in surgical patients. Thus, we designed a prospective clinical study with the aim to determine whether patients undergoing intervention by the OT team have a lower incidence of POD compared to the group treated only with standard measures. Methods: A multicenter, single-blind, randomized clinical trial was conducted between October 2018 and April 2021, in Santiago of Chile, at a university hospital and at a public hospital. Patients older than 75 years undergoing elective major surgery were eligible for the trial inclusion. Patients with cognitive impairment, severe communication disorder and cultural language limitation, delirium at admission or before surgery, and enrolled in another study were excluded. The intervention consisted of OT therapy twice a day plus standard internationally recommended non-pharmacological prevention intervention during 5 days after surgery. Our primary outcome was development of delirium and postoperative subsyndromal delirium. Results: In total 160 patients were studied. In the interventional group, treated with an intensive prevention by OT, nine patients (12.9%) developed delirium after surgery and in the control group four patients (5.5%) [p = 0.125, RR 2.34 CI 95 (0.75-7.27)]. Whereas subsyndromal POD was present in 38 patients in the control group (52.1%) and in 34 (48.6%) in the intervention group [p = 0.4, RR 0.93 CI95 (0.67-1.29)]. A post hoc analysis determined that the patient's comorbidity and cognitive status prior to hospitalization were the main risk factors to develop delirium after surgery. Discussion: Patients undergoing intervention by the OT team did not have a lower incidence of POD compared to the group treated only with standard non-pharmacological measures in adults older than 75 years who went for major surgery. Clinical trial registration: www.ClinicalTrials.gov, identifier NCT03704090.

Cancer History Is Associated with Slower Speed of Cognitive Decline in Patients with Amnestic Cognitive Impairment.

BACKGROUND: Several epidemiological studies report a negative association between Cancer and Alzheimer's disease (AD). OBJECTIVE: To characterize the trajectories of memory loss in individuals with early amnestic cognitive impairment with and without history of previous cancer. METHODS: Cognitive deterioration was assessed using the Montreal Cognitive Assessment (MoCA) or MoCA-Memory Index Score (MoCA-MIS) biannually in subjects with early amnestic cognitive impairment followed-up retrospectively from 2007 to 2021. History of Cancer was obtained from clinical records. Simple linear regressions of MoCA-MIS scores were calculated for each subject and analyzed with K-means cluster analysis to identify subgroups with different cognitive decline trajectories. χ2 and t tests were used for descriptive categorical and continuous variables and mixed multiple linear regressions to determine cognitive decline covariates. RESULTS: Analysis of the trajectory of cognitive decline in 141 subjects with early amnestic cognitive impairment identified two subgroups: Fast (n = 60) and Slow (n = 81) progressors. At baseline Fast progressors had better MoCA-MIS (p < 0.001) and functionality (CDR p = 0.02, AD8 p = 0.05), took less anti-dementia medications (p = 0.005), and had higher depression rates (p = 0.02). Interestingly, Fast progressors slowed their speed of memory decline (from 1.6 to 1.1 MoCA-MIS points/year) and global cognitive decline (from 2.0 to 1.4 total MoCA points/year) when Cancer history was present. CONCLUSION: Two trajectories of amnestic cognitive decline were identified, possibly derived from different neurophysiopathologies or clinical stages. This study suggests that a history of previous Cancer slows down amnestic cognitive decline, specifically in a subgroup of subjects with depression at baseline and accelerated deterioration at follow-up.

Regional Hypertonic Citrate Anticoagulation in Membrane Therapeutic Plasma Exchange: A Case Series.

RATIONALE: Protocols for regional citrate anticoagulation with the hypertonic 4% trisodium citrate solution have been recently described as an anticoagulation strategy during membrane therapeutic plasma exchange (mTPE). The effect of citrate in the patient's systemic hemostasis is negligible, thus regional citrate anticoagulation application is advantageous in circumstances in which heparin-based protocols are deemed unsafe for patients with a high risk of bleeding. The downsides of using hypertonic citrate solutions are mainly hypocalcemia and hypernatremia that ultimately can cause adverse clinical events. PRESENTING CONCERNS OF THE PATIENT: (1) A 57-year-old Caucasian female with a history of active vaginal bleeding secondary to endometrial hyperplasia. She had a history of antiphospholipid syndrome, and systemic lupus erythematosus with marked refractory autoimmune thrombocytopenia. Her platelet count was persistently below 4,000/mm3 even after different immunosuppressive regimens and daily platelet transfusions. (1) A 70-year-old Caucasian female was hospitalized presenting acute kidney injury stage 3 due to rapidly progressive antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, however without the need for renal replacement therapy. At admission, serum creatinine (sCr) was 3.56 mg/dL (normal range: 0.53-1.00 mg/dL). Her baseline sCr was 0.8 mg/dL obtained 6 months earlier. Chest tomography revealed bilateral masses compatible with granulomatous lesions and no signs of alveolar bleeding. Since severe cases of ANCA vasculitis involving the lungs may evolve with alveolar hemorrhage, heparin was avoided. DIAGNOSES: (1) Systemic lupus erythematosus-associated autoimmune thrombocytopenia and (2) ANCA-associated vasculitis with kidney and lung involvement. INTERVENTIONS: Herein, we describe a case series of 12 consecutive mTPE treatments in 2 different patients using regional 4% trisodium citrate anticoagulation. OUTCOMES: All the sessions were uneventful, presented only minor electrolyte imbalances, and were effectively completed without early interruptions due to clotting of the plasmafilter. TEACHING POINTS: In our 2 cases, extracorporeal regional citrate anticoagulation was successful in optimizing plasmafilter patency without bleeding events in 2 high-risk patients using established protocols for the citrate and calcium infusions.

FONDEMENT: Les protocoles d'anticoagulation régionale avec une solution hypertonique à 4 % de citrate trisodique ont récemment été décrits comme stratégie d'anticoagulation pendant les séances d'échange plasmatique par filtration (mTPE ­ membrane therapeutic plasma exchange). L'effet du citrate étant négligeable sur l'hémostase systémique du patient, l'anticoagulation régionale au citrate s'avère avantageuse dans les cas où les protocoles avec l'héparine sont jugés dangereux pour les patients dont le risque d'hémorragie est élevé. Les inconvénients liés aux solutions hypertoniques de citrate sont principalement l'hypocalcémie et l'hypernatrémie, lesquelles peuvent éventuellement entraîner des effets indésirables sur le plan clinique. PRÉSENTATION DES CAS: a) Une femme de race blanche âgée de 57 ans qui présentait des saignements vaginaux actifs en raison d'une hyperplasie de l'endomètre. La patiente avait des antécédents de syndrome antiphospholipide et de lupus érythémateux disséminé avec thrombopénie autoimmune réfractaire marquée. Sa numération plaquettaire demeurait invariablement inférieure à 4 000/mm3 malgré différents traitements immunosuppresseurs et la transfusion quotidienne de plaquettes. b) Une femme de race blanche âgée de 70 ans hospitalisée pour une insuffisance rénale aiguë de stade 3 due à une vascularite à évolution rapide associée aux anticorps cytoplasmiques antineutrophiles (ANCA). La patiente ne nécessitait aucun traitement de remplacement rénal. Son taux de créatinine sérique (SCr) à l'admission était de 3,56 mg/dL (plage normale : 0,53 à 1,00 mg/dL) alors que son taux initial, mesuré 6 mois plus tôt, était de 0,8 mg/dL. Une tomographie thoracique a révélé des masses bilatérales compatibles avec les lésions granulomateuses et l'absence de saignement alvéolaire. L'héparine a été écartée puisque les cas graves de vascularite associée aux ANCA avec atteinte des poumons peuvent évoluer vers une hémorragie alvéolaire. DIAGNOSTICS: a) Thrombocytopénie autoimmune associée à un lupus érythémateux disséminé; b) vascularite associée aux ANCA avec atteinte des reins et des poumons. INTERVENTIONS: Nous décrivons une série de cas impliquant deux patientes ayant subi 12 séances de mTPE consécutives avec un anticoagulant régional à 4 % de citrate trisodique. RÉSULTATS: Toutes les séances se sont déroulées sans incident, seuls des déséquilibres électrolytiques mineurs ont été observés. Toutes les séances ont été réalisées efficacement, sans interruption précoce due au blocage du filtre à plasma. ENSEIGNEMENTS TIRÉS: Dans deux cas qui présentaient un risque élevé d'hémorragie, l'anticoagulation régionale extracorporelle avec citrate, réalisée conformément aux protocoles établis pour les perfusions de citrate et de calcium, a permis d'optimiser la perméabilité du filtre à plasma sans causer d'événement hémorragique.

Perspectivas y tendencias actuales del concepto de alienación parental: una revisión sistemática de la literatura / Current perspectives and trends of the concept of parental alienation: a systematic review of the literature

Resumen: Antecedentes: Son diversos las/os investigadoras/es que se han interesado por el fenómeno de la alienación parental. No obstante, esta compleja dinámica relacional no ha estado exenta de controversias. Objetivo: Realizar una revisión sistemática de las perspectivas y tendencias actuales del concepto de alienación parental, sus características y efectos en la población que experimentan estas circunstancias. Método: Se utilizó la metodología PRISMA-P para llevar a cabo una búsqueda bibliográfica exhaustiva de artículos publicados entre el año 2016 y junio de 2020 en revistas indexadas Scopus y/o WOS. Se contemplaron 95 estudios, de los cuales 11 fueron considerados para la revisión, de acuerdo con los criterios de inclusión y exclusión preestablecidos. Se identificó un amplio campo investigativo en el cual se circunscribe la alienación parental, como dinámica relacional. Resultados: Los 11 estudios seleccionados establecían relaciones entre la experiencia de alienación parental e indicadores de salud mental, tanto en niños, niñas, adolescentes, como adultos que experimentan o experimentaron estas dinámicas. Así también, se relacionó con maltrato psicológico. Conclusiones: La alienación parental es un fenómeno con una importante prevalencia en la población y se ha vinculado con un deterioro en la salud mental de las personas que la experimentan o la han experimentado.

Abstract: Background: Several researchers have been interested in the phenomenon of parental alienation. However, this complex relational dynamic has not been without controversy. Objective: To conduct a systematic review of current perspectives and trends on the concept of parental alienation, its characteristics and effects on the population experiencing these circumstances. Method: PRISMA-P methodology was used to conduct an exhaustive literature search of articles published between 2016 and June 2020 in Scopus and/or WOS indexed journals. Ninety-five studies were contemplated, of which 11 were considered for the review, according to the pre-established inclusion and exclusion criteria. A broad field of research was identified in which parental alienation is circumscribed as a relational dynamic. Results: The 11 selected studies established relationships between the experience of parental alienation and mental health indicators, both in children, adolescents and adults who experience or have experienced these dynamics. Thus, it was also related to psychological maltreatment. Conclusions: Parental alienation is a phenomenon with a significant prevalence in the population and has been linked to a deterioration in the mental health of people who experience or have experienced it.

Extending the integrate-and-fire model to account for metabolic dependencies.

It is widely accepted that the brain, like any other physical system, is subjected to physical constraints that restrict its operation. The brain's metabolic demands are particularly critical for proper neuronal function, but the impact of these constraints continues to remain poorly understood. Detailed single-neuron models are recently integrating metabolic constraints, but these models' computational resources make it challenging to explore the dynamics of extended neural networks, which are governed by such constraints. Thus, there is a need for a simplified neuron model that incorporates metabolic activity and allows us to explore the dynamics of neural networks. This work introduces an energy-dependent leaky integrate-and-fire (EDLIF) neuronal model extension to account for the effects of metabolic constraints on the single-neuron behavior. This simple, energy-dependent model could describe the relationship between the average firing rate and the Adenosine triphosphate (ATP) cost as well as replicate a neuron's behavior under a clinical setting such as amyotrophic lateral sclerosis (ALS). Additionally, EDLIF model showed better performance in predicting real spike trains - in the sense of spike coincidence measure - than the classical leaky integrate-and-fire (LIF) model. The simplicity of the energy-dependent model presented here makes it computationally efficient and, thus, suitable for studying the dynamics of large neural networks.

Insatisfacción corporal y comportamientos alimentarios anómalos en una muestra comunitaria de adultos chilenos / Body dissatisfaction and abnormal eating behaviors in a community sample of Chilean adults

Resumen En Latinoamérica se han realizado estudios dirigidos a evaluar la insatisfacción corporal y los comportamientos alimentarios anómalos (CAA), sin embargo se han enfocado principalmente en adolescentes o estudiantes universitarios. El objetivo de esta investigación fue evaluar el porcentaje de insatisfacción con el peso corporal (INCP) en una muestra de hombres y mujeres adultos chilenos, analizando la relación de este factor con distintas variables sociodemográficas, psicológicas y conductuales, entre las que figuraron los CAA. Participaron 654 adultos de 18-64 años de edad (436 mujeres, 218 hombres ; con rango de edad de 18-64 años, índice de masa corporal promedio de 25.49 kg/m2), quienes fueron evaluados con base a una batería de cuestionarios de autoreporte. La INCP estuvo presente en 45.9% de la muestra, resultando significativamente mayor en las mujeres que en los varones. Fueron identificadas diferencias significativas en las escalas que evaluaron CAA, en función del índice de masa corporal y el sexo de los participantes, registrando puntuaciones significativamente mayores las mujeres y los participantes con obesidad. Al comparar entre participantes con vs. sin INCP, los primeros mostraron más CAA y menor actividad física. Los resultados de este estudio muestran que la INCP puede interactuar e influir sobre los hábitos alimentarios y la práctica de ejercicio físico.

Abstract The aims of this research were to estimate the percentage of body weight dissatisfaction in males and females Chilean adults, assessing its relationship with different sociodemographic, behavioral and psychological variables, and analyzing whether the presence of body weight dissatisfaction acts as a risk factor for some disordered eating behaviors. The 654 participants (436 women, 218 men; age range 18-64 years, mean body mass index [BMI] 25.49 kg/m2) were evaluated with a battery of self-administered questionnaires. The percentage of body weight dissatisfaction in the whole sample was 45.9% and significantly higher in women than men. Significant differences were observed in the clinical scales that evaluated disordered eating in function of the BMI of the participants; in those scales females also showed higher scores than males. Comparing participants with and without body weight dissatisfaction, the first one showed more unhealthy eating behaviors. The results of this study show how body weight dissatisfaction can interact and influence healthy habits, such as a daily eating behaviors and physical exercise.

Evaluación de la efectividad, seguridad y costos del tratamiento antimicrobiano intravenoso ambulatorio (TAIA) vs hospitalizado en infección urinaria en pediatría / Evaluation of the effectiveness, safety and costs of outpatient intravenous antimicrobial treatment (OPAT) vs hospitalized in urinary infection in Pediatrics

Background: Childrens hospitalization for intravenous antibiotic treatment has been replaced in developed countries and in some Chilean centers to outpatient intravenous therapy (OPAT). Aim: To compare the effectiveness, safety and cost of OPAT versus inpatient care. Patients andMethods: Prospective cohort study in children (2 months-5 years) with febrile urinary tract infection (UTI) attended at two public Chilean hospitals: outpatient cohort and inpatient cohort. Between November of 2009-2010, 111 children were enrolled in OPAT and between January 2010-June 2011, 81 children were hospitalized. Demographic data, costs and parental care, response to treatment, adverse events and complications were registered. Results: There was no difference in the effectiveness of both treatments (100% in OPAT and 98.6% in inpatient cohort, p: 0.41). Adherence to OPAT was 100%. Prevalence of adverse events was higher in inpatient cohort (76.3% versus 16.2%, p < 0.01). The average direct cost was four times higher in inpatients, mainly due to bed-day cost. Indirect cost was similar in both groups. There were more days of absence from work and care centers in inpatients (p: 0.017, p: 0.045 respectively). Conclusion: OPAT for febrile UTI was equally effective, safer and significantly less expensive than inpatient care. OPAT represents a recommended intervention for pediatric services of Chilean public hospitals.

Introducción: La hospitalización de niños para tratamiento antimicrobiano intravenoso, ha sido reemplazada en países desarrollados y en algunos centros chilenos por el tratamiento antimicrobiano intravenoso ambulatorio (TAIA). Objetivo: Comparar efectividad, seguridad y costos de TAIA versus hospitalizado. Pacientes y Métodos: Se efectuó un estudio de cohorte prospectiva en niños (2 meses-5 años) con infección urinaria (ITU) febril atendidos en dos hospitales públicos chilenos: una cohorte ambulatoria y otra hospitalizada. Entre noviembre 2009 y 2010, se enrolaron 111 niños en TAIA y entre enero 2010-junio 2011, 81 niños hospitalizados. Se registraron datos demográficos, gastos de atención y de los padres, respuesta al tratamiento, eventos adversos y complicaciones. Resultados: No hubo diferencia en la efectividad de ambos tratamientos (100% en TAIA y 98,6% en hospitalizado; p: 0,41). La adherencia a TAIA fue 100%. La prevalencia de eventos adversos fue mayor en los hospitalizados (76,3 versus16,2%, p < 0,01). El costo directo promedio fue cuatro veces superior en hospitalizados, principalmente por costo día-cama. El costo indirecto fue similar. Hubo más días de ausentismo laboral y a centros de cuidado en hospitalizados (p: 0,017, p: 0,045, respectivamente). Conclusión: El tratamiento de ITU febril con TAIA en niños fue igualmente efectivo, más seguro y significativamente menos costoso que el hospitalizado y representa una intervención recomendable para los servicios pediátricos de hospitales públicos chilenos.

A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data.

BACKGROUND: Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotavirus vaccines have now been developed and extensively studied for their potential association with IS. This study aimed to describe the epidemiology and to estimate the incidence of IS in Latin American infants prior to new vaccine introduction. METHODS: Children under 2 years of age representing potential IS cases were enrolled in 16 centers in 11 Latin American countries from January 2003 to May 2005. IS cases were classified as definite, probable, possible or suspected as stated on the Brighton Collaboration Working Group guidelines. RESULTS: From 517 potential cases identified, 476 (92%) cases were classified as definite, 21 probable, 10 possible and 10 suspected for intussusception. Among the 476 definite IS cases, the median age at presentation was 6.4 months with 89% of cases aged <1 year. The male to female ratio was 1.5:1. The incidence of definite IS per 100,000 subject-years ranged from 1.9 in Brazil to 62.4 in Argentina for children <2 years of age, and from 3.8 in Brazil to 105.3 in Argentina for children aged <1 year. Median hospital stay was 4 days with a high prevalence of surgery as the primary treatment (65%). Most cases (88%) made a complete recovery, but 13 (3%) died. No clear seasonal pattern of IS cases emerged. CONCLUSIONS: This study describes the epidemiology and estimates the incidence of IS in Latin American infants prior to the introduction of new rotavirus vaccines. The incidence of IS was found to vary between different countries, as observed in previous studies. TRIAL REGISTRATION: Clinical study identifier 999910/204 (SERO-EPI-IS-204).

Modificación en el esquema de vacunación antipertussis en Chile, vacunación en grupos especiales y estrategias de control: Comentario del Comité Consultivo de Inmunizaciones (CCI) de la Sociedad Chilena de Infectología / Modification of pertussis vaccination schedule in Chile, immunization of special groups and control strategies: Commentary from the Consultive Committee of Immunizations of The Chilean Society of Infectious Diseases

In Chile, an increased number of notifications of cases of whooping cough was detected at the beginning of October 2010, and maintained through 2012. Accumulated cases during 2011 were 2,581 (15.0 per 100,000), which is greater than the number of cases registered during the period 2008-2010 (2,460 cases). On the other hand, the local sanitary authority introduced a modification of pertussis vaccination schedule (starting 2012), which consists in the replacement of the second booster of pertussis vaccine (DTwP, administered to 4-year-old children) as well as diphtheria-tetanus toxoid (dT, administered to second grade scholars) for an acellular pertussis vaccine with reduced antigenic content (dTpa), which will be administrated to first grade scholars. The Consultive Committee of Immunizations considers that the modification is adequate, since it extends the age of protection, reducing at least in theory the infection in older scholars and adolescents -who are significant sources of transmission of Bordetella pertussis to infants- using an adequate vaccine formulation (acellular pertussis vaccine). The available evidence regarding vaccination in special groups (adolescents and adults, health-care workers and pregnant women) and cocooning strategy are commented.

En Chile, a comienzos del mes de octubre de 2010 se detectó un aumento en la notiicación de casos de coqueluche, dinámica que se ha mantenido a la fecha (abril 2012). El número de casos acumulados durante 2011 ascendió a 2.581 (15,0/100.000 hab.), cifra superior al número de casos registrados durante el período 2008-2010 (2.460 casos). Por su parte, a partir de 2012 la autoridad sanitaria introdujo una modiicación en el esquema de vacunación anti-pertussis, consistente en el reemplazo del segundo refuerzo de vacuna antipertussis (DTwP, administrada a los 4 años) y del refuerzo de toxoide diftérico-tetánico (dT, administrado en segundo básico) por la vacuna anti-pertussis acelular de contenido antigénico reducido (dTpa), a ser administrada en primero básico. El Comité Consultivo de Inmunizaciones considera la modificación adecuada, por cuanto permite extender el tiempo de protección, reduciendo al menos en teoría la infección en escolares mayores y adolescentes -quienes son importantes fuente de contagio de Bordetella pertussis para los lactantes- utilizando una adecuada formulación de vacuna (vacuna antipertussis acelular). Se comenta la evidencia disponible sobre vacunación anti-pertussis en grupos especiales (adolescentes y adultos, funcionarios de la salud y mujeres embarazadas), y la estrategia de vacunación de capullo.

Genotipos de rotavirus aislados de niños chilenos con gastroenteritis atendidos en dos hospitales públicos: variantes virales circulantes en un país con uso limitado de vacunas anti-rotavirus / Rotavirus genotypes in children with gastroenteritis assisted in two public hospitals from Chile: viral strains circulating in a country without a universal vaccination against rotavirus

Background: Rotavirus is the main cause of severe gastroenteritis (GE) in children. Two vaccines currently available have proven efficacy against the predominant genotypes. Rotavirus genotypes vary both geographically and/or temporally. Genotype surveillance is important to monitor trends associated or not with vaccine use. Aim: To update information on rotavirus genotypes circulating in two main cities of Chile. Methodology: Between May 2009-March 2010, children < 5y of age receiving medical care for GE in two large hospitals were recruited; none of these children had received rotavirus vaccine previously. Epidemiological information was recorded in an ad-hoc form and stool samples were collected for rotavirus detection by a commercial ELISA. Genotyping was performed by semi-nested RT-PCR. Results: A total of 296/967 samples (31%) were positive for rotavirus, with a peak in November/ December mostly in children 7-24 months old (67%). G9P[8] was the predominant genotype (76%), followed for G1P[8] (6%) and G2P[4] (6%) in both cities. Conclusions: Rotavirus caused one third of GE requiring emergency room care and/or hospitalization, mostly in children within an age range susceptible to benefit from rotavirus vaccines. G9P[8], a genotype against which rotavirus vaccines have demonstrated high efficacy, was by far the most frequent rotavirus variant. Continued surveillance in Chile is crucial for providing background information on disease burden and strain diversity before the introduction of rotavirus vaccines.

Antecedentes: Rotavirus es la principal causa de gastroenteritis (GE) grave en niños. Actualmente se dispone de dos vacunas con eficacia demostrada contra los genotipos predominantes en el mundo. Los genotipos de rotavirus varían en el tiempo y de una región a otra. Es importante mantener la vigilancia de los genotipos circulantes para monitorizar las tendencias asociadas o no al uso de vacunas. Objetivo: Actualizar la información sobre genotipos de rotavirus circulantes en dos ciudades importantes de Chile (Santiago y Valparaíso). Metodología: Entre mayo 2009 y marzo 2010 se reclutaron niños bajo 5 años de edad con GE atendidos en dos hospitales; ninguno de ellos con historia previa de vacunación anti-rotavirus. Se registró información epidemiológica y se tomó muestra de deposición para detección de rotavirus mediante ELISA comercial. Se realizó genotipificación mediante RPC-TR semi-anidada. Resultados: Se detectó rotavirus en 296/967 muestras analizadas (31%), con un pico de frecuencia en noviembre/diciembre y afectando predominantemente al grupo de 7-24 meses de edad (67%). G9P[8] fue el genotipo predominante (76%), seguido por G1P[8] (6%) y G2P[4] (6%) en ambas ciudades. Conclusiones: Rotavirus causó un tercio de las GE en este grupo, afectando especialmente al grupo de edad que podría beneficiarse con la vacunación anti-rotavirus. G9P[8], una de las variantes contra las cuales las vacunas antirotavirus han demostrado alta eficacia, fue por lejos el genotipo más frecuente. Es necesario continuar la vigilancia en Chile de modo de conocer el impacto de la enfermedad y diversidad de variantes antes de la incorporación de una vacuna anti-rotavirus.

[Human papillomavirus vaccine. Statement of the Advisory Committee of Immunizations on behalf of the Chilean Infectious Diseases Society. September 2008]. / Declaración del Comité Consultivo de Inmunizaciones de la Sociedad Chilena de infectología respecto a la vacuna antivirus papiloma humano. Septiembre 2008.

This article briefly reviews the epidemiology of human papillomavirus (HPV) infection and associated diseases globally and in Chile, and the scientific information of the licensed HPV vaccines: Gardasil and Cervari. Considering the available information, the Advisory Committee on Immunizations of the Chilean Society of Infectious Diseases recommends vaccination of teenage girls, ideally before initiating sexual activity, i.e., approximately at the age of 12 to 13 years and vaccination of women of any age if they have not started sexual activity. If women are vaccinated after initiating sexual activity, they should be informed of the lower efficacy of immunization if HPV infection has occurred. Education on responsible sexuality and sexually transmitted diseases should be maintained as a priority. Vaccination should be highly considered for inclusion in the National Immunization Program.