RESUMO
Señor editor: La infección por SARS-CoV-2 ha ocasionado gran impacto en todo el mundo estimándose en más de 439 millones de casos y más de 5,9 millones de muertes. El Perú ha sido uno de los países en donde la mortalidad de su población ha descrito cifras muy elevadas llegando hasta una tasa de letalidad de 9.14%. Iquitos ha sido una de las ciudades más afectadas desde el inicio de la pandemia en el Perú, en donde se describió una seroprevalencia COVID-19 de 70% una de las más altas reportadas después de la primera ola pandémica de COVID-19. Es de esperar que esta seroprevalencia haya aumentado luego de la segunda ola. La duración de la inmunidad frente al SARS-CoV-2 ya sea por infección previa o por vacunación efectiva continúa siendo una de las interrogantes más importantes, en ese contexto, reportamos 4 casos de reinfecciones conï¬rmadas en Iquitos Perú.
Dear Editor: SARS-CoV-2 infection has caused great impact worldwide, estimated at more than 439 million cases and more than 5.9 million deaths. Peru has been one of the countries where the mortality of its population has described very high figures reaching a case fatality rate of 9.14%. Iquitos has been one of the most affected cities since the beginning of the pandemic in Peru, where a COVID-19 seroprevalence of 70% was described, one of the highest reported after the first COVID-19 pandemic wave. It is to be expected that this seroprevalence has increased after the second wave. The duration of immunity against SARS-CoV-2 either by previous infection or by effective vaccination continues to be one of the most important questions, in that context, we report 4 cases of conï¬rm reinfections in Iquitos Peru.
RESUMO
The exoerythrocytic stage of Plasmodium infection is a critical window for prophylactic intervention. Using genome-wide dual RNA sequencing of flow-sorted infected and uninfected hepatoma cells we show that the human mucosal immunity gene, mucin-13 (MUC13), is strongly upregulated during Plasmodium exoerythrocytic hepatic-stage infection. We confirm MUC13 transcript increases in hepatoma cell lines and primary hepatocytes. In immunofluorescence assays, host MUC13 protein expression distinguishes infected cells from adjacent uninfected cells and shows similar colocalization with parasite biomarkers such as UIS4 and HSP70. We further show that localization patterns are species independent, marking both P. berghei and P. vivax infected cells, and that MUC13 can be used to identify compounds that inhibit parasite replication in hepatocytes. This data provides insights into host-parasite interactions in Plasmodium infection, and demonstrates that a component of host mucosal immunity is reprogrammed during the progression of infection.