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1.
J Infect Dis ; 225(5): 820-824, 2022 03 02.
Artigo em Inglês | MEDLINE | ID: mdl-34746954

RESUMO

BACKGROUND: Previous reports highlighted the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific monoclonal antibodies (mAbs) against coronavirus disease 2019. METHODS: We conducted a prospective study on the clinical outcome and antiviral effects of mAbs added to standard of care therapy in SARS-CoV-2-infected patients with primary antibody defects. RESULTS: Median time of SARS-CoV-2 quantitative polymerase chain reaction (qPCR) positivity was shorter in 8 patients treated with mAbs (22 days) than in 10 patients treated with standard of care therapy only (37 days, P=.026). Median time of SARS-CoV-2 qPCR positivity from mAb administration was 10 days. CONCLUSIONS: The SARS-CoV-2 mAbs treatment was effective and well tolerated in patients with primary antibody defects.


Assuntos
Anticorpos Antivirais/uso terapêutico , Tratamento Farmacológico da COVID-19 , Imunodeficiência de Variável Comum , Doenças da Imunodeficiência Primária/tratamento farmacológico , SARS-CoV-2/isolamento & purificação , Anticorpos Monoclonais/imunologia , Anticorpos Monoclonais/uso terapêutico , Anticorpos Antivirais/imunologia , Antineoplásicos Imunológicos , Humanos , Estudos Prospectivos , Reação em Cadeia da Polimerase em Tempo Real , Padrão de Cuidado
2.
Am J Ther ; 22(1): e8-e13, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-23846525

RESUMO

Drug-induced hepatotoxicity is a common cause of acute hepatitis, and the recognition of the responsible drug may be difficult. We describe a case of clopidogrel-related acute hepatitis. The diagnosis is strongly suggested by an accurate medical history and liver biopsy. Reports about cases of hepatotoxicity due to clopidogrel are increasing in the last few years, after the increased use of this drug. In conclusion, we believe that physicians should carefully consider the risk of drug-induced hepatic injury when clopidogrel is prescribed.


Assuntos
Doença Hepática Induzida por Substâncias e Drogas/etiologia , Inibidores da Agregação Plaquetária/efeitos adversos , Ticlopidina/análogos & derivados , Doença Aguda , Biópsia , Doença Hepática Induzida por Substâncias e Drogas/diagnóstico , Clopidogrel , Feminino , Humanos , Pessoa de Meia-Idade , Ticlopidina/efeitos adversos
3.
J Med Case Rep ; 7: 106, 2013 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-23594801

RESUMO

INTRODUCTION: Rifampicin is one of the most effective antibiotics for treating tuberculosis, but it has been associated with adverse reactions, such as nephrotoxicity, sometimes resulting in acute renal failure with oligoanuria, and hepatotoxicity. Although deterioration of renal function, determined by acute tubulointerstitial nephritis and/or acute tubular necrosis, typically appears in patients receiving intermittent rifampicin therapy, some authors have also reported cases occurring during continuous rifampicin therapy. CASE PRESENTATION: We describe the case of acute renal failure with polyuria occurring in a previously healthy 50-year-old Caucasian man undergoing continuous therapy with rifampicin for culture-confirmed pulmonary tuberculosis. The patient was admitted to the L. Spallanzani National Institute for Infectious Diseases, Rome, Italy, with a 1-month history of coughing, fever and weight loss. After 6 weeks of standard antituberculous treatment, progressive deterioration of his renal function was observed: creatinine levels rose from 38.9µmol/L to 318.2µmol/L and urine volume also progressively increased to reach a state of true polyuria (8 to 10L of urine per day). He was diagnosed with suspected acute rifampicin-induced renal failure. A renal biopsy showed focal segmental glomerulosclerosis associated with acute tubulointerstitial nephritis. Rifampicin was discontinued with excellent results: after 15 days his renal function began to improve and his serum creatinine values returned to normal. CONCLUSION: A high index of suspicion for rifampicin-associated acute renal failure should be maintained in patients with pulmonary tuberculosis who develop progressive deterioration of renal function during treatment with rifampicin. Early diagnosis and discontinuation of rifampicin are of fundamental importance for recovering renal function.

4.
Eur J Immunol ; 32(10): 2711-20, 2002 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-12355422

RESUMO

Kaposi's sarcoma (KS) develops upon reactivation of human herpesvirus 8 (HHV8) infection and virus dissemination to blood and tissue cells, including endothelial and KS spindle cells where the virus is mostly present in a latent form. However, this may likely require the presence of compromised host immune responses and/or the evasion of infected cells from the host immune response. In this regard, mechanisms of evasion of productively infected cells from both CTL and NK cell responses, and resistance of latently infected cells from specific CTL, have already been shown. Here we show that cells which are latently infected by HHV8 are indeed efficiently lysed by NK cells from individuals with a normal immune response. Notably, NK cell-mediated immunity was found to be significantly reduced in AIDS patients with progressing KS as compared to both HIV-negative patients with indolent classic KS or normal blood donors. However, it was restored after treatment with the highly active antiretroviral therapy (HAART) in AIDS-KS patients, that showed regression and clearance of HHV8 from PBMC. By contrast, AIDS-KS patients with a more aggressive disease and no clinical response had persistent HHV8 viremia associated with reduced NK cell cytotoxicity. These results suggest a key role for NK cells in the control of HHV8 latent infection, KS development, and in disease remission upon HAART.


Assuntos
Síndrome da Imunodeficiência Adquirida/tratamento farmacológico , Terapia Antirretroviral de Alta Atividade , Herpesvirus Humano 8/imunologia , Células Matadoras Naturais/imunologia , Sarcoma de Kaposi/imunologia , Síndrome da Imunodeficiência Adquirida/imunologia , Síndrome da Imunodeficiência Adquirida/virologia , Anticorpos Antivirais/sangue , Citotoxicidade Imunológica , DNA Viral/sangue , Herpesvirus Humano 8/isolamento & purificação , Humanos , Sarcoma de Kaposi/virologia
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