RESUMO
Data on deleterious variants in genes other than BRCA1/2 remain limited. A retrospective cohort study was performed, including primary OC cases with TruRisk® germline gene panel testing between 2011 and 2020. Patients with testing after relapse were excluded. The cohort was divided into three groups: (A) no mutations, (B) deleterious BRCA1/2 mutations, and (C) deleterious mutations in other genes. A total of 702 patients met the inclusion criteria. Of these 17.4% (n = 122) showed BRCA1/2 mutations and a further 6.0% (n = 42) in other genes. Three-year overall survival (OS) of the entire cohort was significantly longer in patients with germline mutations (85%/82.8% for cohort B/C vs. 70.2% for cohort A, p < 0.001) and 3-year progression-free survival (PFS) only for cohort B (58.1% vs. 36.9%/41.6% in cohort A/C, p = 0.002). In multivariate analysis for the subgroup of advanced-stages of high-grade serous OC, both cohorts B/C were found to be independent factors for significantly better outcome, cohort C for OS (HR 0.46; 95% CI 0.25-0.84), and cohort B for both OS and PFS (HR 0.40; 95% CI 0.27-0.61 and HR 0.49; 95% CI 0.37-0.66, respectively). Germline mutations were detected in a quarter of OC patients, and a quarter of those in genes other than BRCA1/2. Germline mutations demonstrate in our cohort a prognostic factor and predict better prognosis for OC patients.
RESUMO
STUDY OBJECTIVE: To evaluate trocar stability using a fixation device to control trocar insertion depth and in particular to provide greater stability during laparoscopic procedures, and to evaluate the effects of using a fixator to control mobility of trocars. DESIGN: Non-blinded prospective study (Canadian Task Force classification II-2). SETTING: University hospital department of gynecology, obstetrics, and gynecological oncology. PATIENTS: Forty-three patients scheduled to undergo gynecologic laparoscopic intervention with planned operative time >10 minutes. INTERVENTIONS: In all procedures, 5-mm working trocars bearing a plain (smooth) sleeve were used. The fixator device, consecutively either on the left or right side, was attached to 1 of 2 side trocars before insertion. In 18 patients, an unsutured fixator was used (FX-US subgroup). In the remaining 25 patients, the device was sutured to the skin via specially designed suturing ports (FX-S subgroup). The position of both trocars in the groups with a fixator (FX group) and without a fixator (NFX group) in the abdominal wall was evaluated at the start of the procedure and every 10 minutes intraoperatively. MEASUREMENTS AND MAIN RESULTS: In the FX group, there was significantly decreased trocar movement compared with the NFX group (mean [SD] 0.02 [0.6] cm vs 0.84 [4.4] cm). In addition, in the NFX group, the trocar tended to slip into the abdomen during the operation, whereas in the FX group, trocars tended to slip out. Of 43 ports, 11 (25.6%) had to be either reinserted or readjusted at some point during the operation. In 2 procedures, reinsertion of the trocar at exactly the same location was impossible. In the FX-US subgroup, there was 1 incidence of trocar dislocation, whereas there were no dislocations in the FX-S subgroup. The difference in the effect between the 2 study arms, fixator unsutured and fixator sutured, was expected to produce only a small benefit in the sutured fixator arm; however, the benefit was greater than anticipated. CONCLUSION: Use of a fixator significantly reduces plain (smooth) sleeve trocar movement and prohibits complete dislocation or slippage of the port, and suturing the device to the skin further minimizes trocar movement. Trocar stabilization via a fixation device may lead to shorter operative time and reduce problems associated with trocar slippage or dislocation.