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OBJECTIVE: To investigate the clinical features of Wilson's disease (WD) for the purpose of avoiding misdiagnosis and therefore improving the prognosis of this rare disease. METHODS: This study enrolled all the patients diagnosed as WD who were admitted to West China Hospital, Sichuan University from Jan 2008 to Dec 2014. Their clinical manifestations, head and abdominal images data were extracted and analyzed. RESULTS: There were a total of 126 patients of WD, male female ratio was 75 : 51, median age was 21-years old. 10.3% (13/126) of them had family history, 87.3% (109/126) patients presented with neuropsychiatric symptoms, 14.3% (18/126) patients manifested as chronic liver disease. All patients had decreased serum ceruloplasmin level < 200 mg/L, 121 (96.9%) patients had serum ceruloplasmin level < 100 mg/L. Magnetic resonance imaging and abdominal ultrasound detected structural abnormalities in 92.7% (102/110) and 88.9% (97/109) patients respectively. Kayser-Fleischer rings on slit-lamp ophthalmologic examination was found in 98.3% (115/117) patients. One patient underwent liver biopsy and the result of rhodanine stain was positive. The time from onset to diagnosis varied from 3 d to 19 years [(1.59 ± 2.66) years]. 20 (15.9%) patients were initially misdiagnosed. CONCLUSION: The patients presenting with neurological signs or unexplained liver disease should be assessed carefully for WD. Serum ceruloplasmin, 24-h urinary copper, Kayser-Fleischer rings and sometimes even liver biopsy could be helpful for the diagnosis.
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Degeneração Hepatolenticular/diagnóstico , Degeneração Hepatolenticular/patologia , Biópsia , Ceruloplasmina/análise , China , Cobre/urina , Feminino , Humanos , Hepatopatias/patologia , Imageamento por Ressonância Magnética , Masculino , Estudos Retrospectivos , Lâmpada de Fenda , Adulto JovemRESUMO
PURPOSE: To explore the value of diffusion-weighted imaging (DWI) and magnetic resonance imaging (MRI) on the follow-up of nasopharyngeal carcinoma (NPC) after radiotherapy. MATERIAL AND METHODS: Eighty-three NPC patients after radiotherapy were divided into two groups: 4 cases of residual tumor and 33 cases of non-residual within 6 months, the cases of recurrent and non-recurrent were 5 and 41 over 6 months, respectively. MRI and DWI imaging of these cases were closely analyzed, and the apparent diffusion coefficient (ADC) of the nasopharyngeal residual mass and nasopharyngeal wall thickening, skull base destruction and lateral pterygoid muscle were measured. RESULTS: The ADC of the lateral pterygoid muscle was (1.501 ± 0.069) × 10
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Imagem de Difusão por Ressonância Magnética/métodos , Neoplasias Nasofaríngeas/patologia , Neoplasias Nasofaríngeas/radioterapia , Adolescente , Adulto , Idoso , Carcinoma , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Carcinoma Nasofaríngeo , Nasofaringe/patologia , Adulto JovemRESUMO
INTRODUCTION: To assess the relation between CT attenuation value and iodine concentration in vitro, using gemstone spectral imaging (GSI) with single-source dual-energy CT and traditional polychromatic X-ray imaging (TPXI), respectively. METHODS: A polypropylene phantom with eight test tubes in which iodine concentrations of solution were 0.4, 0.7, 2, 5, 10, 20, 30 and 50 mg/mL underwent GSI and traditional polychromatic X-ray scans (80, 100, 120 and 140 kV(p)), using single-source dual-energy spectral CT (Discovery CT750HD; GE Healthcare Technologies, Milwaukee, WI, USA) at the same tube speed of 0.8 s/rotation. All spectral imaging data were analysed with GSI viewer to obtain monochromatic images (50-140 keV, interval of 10 keV). Computed tomography attenuation values of iodine solution were measured with the same size of regions of interest and at the exact same level for both monochromatic and polychromatic images. The relation between CT attenuation value and iodine concentration was examined. RESULTS: A linear correlation was found between CT attenuation value and iodine concentration for both monochromatic and polychromatic images. Moreover, the fitting coefficients for CT attenuation values and iodine concentrations were closer to one with GSI (r(2) = 0.99824-0.99996) than that with TPXI (r(2) = 0.99640-0.99736). CONCLUSIONS: Owing to the better correlation coefficients between CT attenuation value and iodine concentration, GSI may be a preferred method for quantitative measurement compared with TPXI.
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Meios de Contraste/análise , Iodo/análise , Intensificação de Imagem Radiográfica/métodos , Interpretação de Imagem Radiográfica Assistida por Computador/métodos , Tomografia Computadorizada por Raios X/métodos , Filme para Raios X , Algoritmos , Humanos , Imagens de Fantasmas , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Estatística como Assunto , Tomografia Computadorizada por Raios X/instrumentaçãoRESUMO
The aim of this study was to evaluate the impact of window settings on measurement of colon polyps with CT virtual colonoscopy with experiment. Twenty-four artificial polyps' diameter were measured and scanned 10 times with identical scan parameters using a 64-multidetector computed tomographic scanner. The diameter of each polyp was measured using lung window and abdominal soft tissue window settings and compared with the actual diameter. The lung window setting offers accurate measurement of colon polyps.
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Pólipos do Colo/diagnóstico por imagem , Colonografia Tomográfica Computadorizada/métodos , Imagens de Fantasmas , Humanos , Interpretação de Imagem Radiográfica Assistida por ComputadorRESUMO
The aim of this study was to evaluate the relative values of 2D plane view and 3D intracavity view of CT virtual colonoscopy in displaying colon excavated lesions. Cleaned porcine colon with ulcerative lesion was scanned with multidetector CT. The data were reconstructed and reviewed using 2D plane view and 3D volume-rendered images on a GE AW4.2 workstation. The 3D volume-rendered images showed superiority in displaying excavated lesions.