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Pediatr Hematol Oncol ; 40(8): 800-806, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37334681

RESUMO

Crouzon Syndrome is a genetic craniosynostosis disorder associated with a high risk of ophthalmologic sequelae secondary to structural causes. However, ophthalmologic disorders due to intrinsic nerve aberrations in Crouzon Syndrome have not been described. Optic pathway gliomas (OPGs) are low grade gliomas that are intrinsic to the visual pathway, frequently associated with Neurofibromatosis type 1 (NF-1). OPGs involving both optic nerves without affecting the optic chiasm are rarely seen outside of NF-1. We report an unusual case of bilateral optic nerve glioma without chiasmatic involvement in a 17-month-old male patient with Crouzon Syndrome without any clinical or genetic findings of NF-1. This case suggests that close ophthalmologic follow up and orbital MRIs may benefit patients with Crouzon Syndrome.


Assuntos
Disostose Craniofacial , Neurofibromatose 1 , Glioma do Nervo Óptico , Neoplasias do Nervo Óptico , Humanos , Masculino , Lactente , Glioma do Nervo Óptico/complicações , Vias Visuais , Neoplasias do Nervo Óptico/complicações , Disostose Craniofacial/complicações
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