RESUMO
CASE PRESENTATION: A 29-year-old Ukrainian woman presented to the obstetric clinic at 28 weeks' gestation with pregnancy complicated by intrauterine growth restriction. She reported progressively worsening dyspnea during her pregnancy and was found to have significant hypoxia with an oxygen saturation of 84% on room air prompting admission for further evaluation. Oxygen saturation improved to 92% on 10 L of supplemental oxygen. On further questioning, she was found to have a history significant for pleurodesis as a treatment for recurrent pneumothoraces and nephrectomy for a benign renal mass several years prior while living in Ukraine.
Assuntos
Dispneia/etiologia , Neoplasias Pulmonares/diagnóstico , Pulmão/diagnóstico por imagem , Linfangioleiomiomatose/diagnóstico , Pneumotórax/complicações , Complicações Neoplásicas na Gravidez , Adulto , Diagnóstico Diferencial , Dispneia/diagnóstico , Feminino , Humanos , Neoplasias Pulmonares/complicações , Linfangioleiomiomatose/complicações , Pneumotórax/diagnóstico , Gravidez , Radiografia Torácica , Tomografia Computadorizada por Raios XRESUMO
This manuscript describes the Ni-catalyzed coupling of azoles with aromatic nitriles. The use of BPh3 promotes these arylations with electronically diverse azoles and benzonitriles. While the nickel catalyst is necessary for the arylations of phenyl oxazoles, arylation of benzoxazoles with some nitriles affords the arylated products even in the absence of the Ni catalyst albeit in lower yield than the catalyzed process. The Ni-catalyzed process exhibits higher rates and a broader scope than the uncatalyzed transformation.