Effect of food on the pharmacokinetics and safety profiles of a new PARP inhibitor fuzuloparib capsules in healthy volunteers.

PURPOSE: This study assessed effect of food on pharmacokinetics (PK) and safety of fuzuloparib capsules. METHODS: A randomized, open-label, two-cycle, two-sequence, crossover clinical trial was conducted. 20 subjects were randomly assigned to 2 groups at a 1:1 ratio. The first group subjects were orally administered 150 mg fuzuloparib capsules under fasting condition in first dosing cycle. The same dose of fuzuloparib capsules were taken under postprandial state after a 7-day washout period. The second group was reversed. 3 ml whole blood was collected at each blood collection point until 72 h post dose. PK parameters were calculated. Furthermore, safety assessment was performed. RESULTS: The time to maximum concentration (Tmax) was prolonged to 3 h and maximum concentration (Cmax) decreased by 18.6% on high-fat diets. 90% confidence intervals (CIs) of geometric mean ratios (GMRs) for Cmax, area under the concentration-time curve from time zero to time t (AUC0-t), and area under the concentration-time curve extrapolated to infinity (AUC0-∞) after high-fat meal were 71.6-92.6%, 81.7-102.7% and 81.6-102.5%, respectively. All treatment-emergent adverse events (TEAEs) were grade 1; No serious adverse events (SAEs), serious unexpected suspected adverse reaction (SUSAR) or deaths were reported. CONCLUSION: Food decreased the absorption rate and slowed time to peak exposure of fuzuloparib capsules, without impact on absorption extent. Dosing with food was found to be safe for fuzuloparib capsules in this study. CLINICAL TRIAL REGISTRATION: This study was registered with chinadrugtrials.org.cn (identifier: CTR20221498).

Study on Oil and Gas Amphiphilic Surfactants Promoting the Miscibility of CO2 and Crude Oil.

In order to cope with the global climate crisis, carbon capture, utilization, and storage are the key technologies to achieve carbon neutrality, and it is an elegant geological utilization method for the oil and gas industry to improve the recovery rate of crude oil by using CO2. However, in practical applications, the problem of low miscibility of CO2 and crude oil, resulting in low oil displacement efficiency, cannot be avoided. Thus, finding an appropriate method to increase the utilization rate of CO2 is a worth in-depth study. In light of this, this paper carries out the study on improving the CO2 flooding efficiency by using oil and gas amphiphilic surfactants. First of all, according to the molecular structure theory and the solubility experiment of surfactants in CO2, five kinds of surfactants and two kinds of additives with good performance of oil and gas were selected. Then, three experiments were conducted to explore the mechanism of the selected surfactants. The main mechanism of promoting the miscibility of CO2-crude oil is to reduce the interfacial tension of the oil and gas phases, followed by increasing the volume expansion of crude oil and reducing the viscosity of crude oil. Finally, through the slim tube displacement experiment, the oil displacement efficiency effect of adding the compound systems of SPO5/n-pentanol was simulated. The results show that the oil displacement efficiency is significantly higher than that of pure CO2 flooding, and the pressure of miscibility reduces at the same time. The selected reagents have a good effect of promoting miscibility. Therefore, this is an effective method to improve the geological utilization of CO2.