[Diagnostic efficacy of prostate cancer using targeted biopsy with 6-core systematic biopsy for patients with PI-RADS 5].

OBJECTIVE: To investigate the diagnostic efficacy of targeted biopsy (TBx), systematic biopsy (SBx), TBx+6-core SBx in prostate cancer (PCa) / clinically significant prostate cancer (cs-PCa) for patients with prostate imaging reporting and data system (PI-RADS) score of 5, and thereby to explore an optimal sampling scheme. METHODS: The data of 585 patients who underwent multiparametric magnetic resonance imaging (mpMRI) with at least one lesion of PI-RADS score 5 at Peking University First Hospital from January 2019 to June 2022 were retrospectively analyzed. All patients underwent mpMRI / transrectal ultrasound (TRUS) cognitive guided biopsy (TBx+SBx). With the pathological results of combined biopsy as the gold standard, we compared the diagnostic efficacy of TBx only, SBx only, and TBx+6-core SBx for PCa/csPCa. The patients were grouped according to mpMRI T-stage (cT2, cT3, cT4) and the detection rates of different biopsy schemes for PCa/csPCa were compared using Cochran's Q and McNemar tests. RESULTS: Among 585 patients with a PI-RADS score of 5, 560 (95.7%) were positive and 25(4.3%) were negative via TBx+SBx. After stratified according to mpMRI T-stage, 233 patients (39.8%) were found in cT2 stage, 214 patients (36.6%) in cT3 stage, and 138 patients (23.6%) in cT4 stage. There was no statistically significant difference in the detection rate of PCa/csPCa between TBx+6-core SBx and TBx+SBx (all P>0.999). Also, there was no statistically significant difference in the detection rate of PCa/csPCa between TBx and TBx+SBx in the cT2, cT3, and cT4 subgroups (PCa: P=0.203, P=0.250, P>0.999; csPCa: P=0.700, P=0.250, P>0.999). The missed diagnosis rate of SBx for PCa and csPCa was 2.1% (12/560) and 1.8% (10/549), and that of TBx for PCa and csPCa was 1.8% (10/560) and 1.4% (8/549), respectively. However, the detection rate of TBx+6-core SBx for PCa and csPCa was 100%. Compared with TBx+SBx, TBx and TBx+6-core SBx had a fewer number of cores and a higher detection rate per core (P < 0.001). CONCLUSION: For patients with a PI-RADS score of 5, TBx and TBx+6-core SBx showed the same PCa/csPCa detection rates and a high detection rates per core as that of TBx+SBx, which can be considered as an optimal scheme for prostate biopsy.

Fluorescent Cadmium Bipillared-Layer Open Frameworks: Synthesis, Structures, Sensing of Nitro Compounds, and Capture of Volatile Iodine.

Fluorescent Cd metal-organic frameworks (MOFs), [Cd2 (dicarboxylate)2 (NI-bpy-44)2 ] (dicarboxylate=benzene-1,4-dicarboxylate (1,4-bdc, 1), 2-bromobenzene-1,4-dicarboxylate (Br-1,4-bdc, 2), 2-nitrobenzene-1,4-dicarboxylate (NO2 -1,4-bdc, 3), biphenyl-4,4'-dicarboxylate (bpdc, 4); NI-bpy-44=N-(pyridin-4-yl)-4-(pyridin-4-yl)-1,8-naphthalimide)), featuring non- and twofold interpenetrating pcu-type bipillared-layer open structures with sufficient free voids of 58.4, 51.4, 51.5, and 41.4 %, respectively, have been hydro(solvo)thermally synthesized. MOFs 1-4 emitted solid-state blue or cyan fluorescence emissions at 447±7 nm, which mainly arose from NI-bpy-44 and are dependent on the incorporated solvents. After immersing the crystalline samples in different solvents, that is, H2 O and DMSO (1 and 2) as well as nitrobenzene and phenol (1-4), they exhibited a remarkable fluorescence quenching effect, whereas o-xylene and p-xylene (4) caused significant fluorescence enhancement. The sensing ability of MOFs 1-4 toward nitro compounds carried out in the vapor phase showed that nitrobenzene and 2-nitrophenol displayed detectable fluorescence quenching with 1, 2, and 4 whereas 4-nitrotoluene was an effective fluorescence quencher for 1 and 2; this is most likely attributed to their electron-deficient properties and higher vapor pressures. Moreover, MOFs 1-4 are highly reusable for quick capture of volatile iodine, as supported by clear crystal color change and also by immense fluorescence quenching responses owing to the donor-acceptor interaction. Low-pressure CO2 adsorption isotherms indicate that activated materials 1'-4' are inefficient at taking up CO2 .

Synthesis, Structure, and Dye Adsorption Properties of a Nickel(II) Coordination Layer Built from d-Camphorate and Bispyridyl Ligands.

Reaction of NiCl2∙6H2O, d-camphoric acid (d-H2cam), and N,N'-bis(pyraz-2-yl)piperazine (bpzpip) in pure water at 150 °C afforded a novel nickel(II) coordination layer, [Ni4(d-cam)2(d-Hcam)4(bpzpip)4(H2O)2] (1), under hydro(solvo)thermal conditions. Single-crystal X-ray structure analysis reveals that 1 adopts a six-connected two-dimensional (2D) chiral layer structure with 36-hxl topology. Dye adsorption explorations indicate that 1 readily adsorbs methyl blue (MyB) from water without destruction of crystallinity. On the contrary, methyl orange (MO) is not adsorbed at all. The pseudo-second-order kinetic model could be used to interpret the adsorption kinetics for MyB. Equilibrium isotherm studies suggest complicated adsorption processes for MyB which do not have good applicability for either the two-parameter Langmuir or Freundlich isotherm model. The saturated adsorption capacity of 1 for MyB calculated by Langmuir is 185.5 mg·g-1 at room temperature.

Clinical analysis of the PADUA and the RENAL scoring systems for renal neoplasms: a retrospective study of 245 patients undergoing laparoscopic partial nephrectomy.

OBJECTIVE: To investigate the clinical significance of preoperative aspects and dimensions used for anatomic (PADUA) and radius exophytic/endophytic nearness anterior/posterior location (RENAL) scoring systems for renal neoplasms in patients undergoing laparoscopic partial nephrectomy. METHODS: A retrospective analysis was carried out on clinical data of 245 Chinese patients with renal neoplasms undergoing laparoscopic partial nephrectomy from June 2008 to June 2012. The perioperative complications and variables, as well as PADUA and RENAL score, were compared. RESULTS: The PADUA and RENAL scoring systems were significantly associated with percent change in estimated glomerular filtration rate (P = 0.032 and P = 0.026 respectively), whereas the RENAL scoring system was also significantly associated with warm ischemia time (P = 0.032). On multivariate analysis, both scores were able to predict percent change in estimated glomerular filtration rate (PADUA, P = 0.011; RENAL, P = 0.028). There were no significant associations between the two scoring systems assessed and the occurrence of complications or tumor stage. The correlation between PADUA classification and RENAL nephrometry score was significant (P < 0.0001). Fleiss' generalized kappa was 0.69-0.89 for the various components of the PADUA score and 0.67-0.89 for the RENAL nephrometry components. CONCLUSIONS: The PADUA classification and RENAL nephrometry score are comprehensive assessment tools for delineating renal tumor anatomy. The reproducibility of the PADUA and RENAL scores is substantial, but further research is required to evaluate its performance in more accurately predicting operative and patient-related outcomes.

[Clinical analysis of the application of R.E.N.A.L. nephrometry score for the nephron sparing surgery].

OBJECTIVE: To investigate the clinical significance of R.E.N.A.L. nephrometry score for renal neoplasms in patients undergoing nephron sparing surgery. METHODS: A retrospective analysis was conducted of clinical data of 110 patients with renal neoplasms undergoing nephron sparing surgery, who were admitted to Peking University First Hospital from January 2010 to January 2012. The operation approaches, perioperative variables and perioperative complications as well as R.E.N.A.L. scores were compared. RESULTS: The R.E.N.A.L. nephrometry score was significantly associated with the operation approach (P<0.001), while there was no significant association between the scoring system and the occurrence of complications (P<0.611). Meanwhile, it was associated with ischemia time (P<0.023) and percentage change in the creatinine level (P<0.025). Low complexity tumors had significantly shorter ischemia time and low percentage change in the creatinine level than high complexity tumors (P<0.008, P<0.010). Fleiss' generalized kappa was 0.52 to 0.89 for the R.E.N.A.L. nephrometry components. CONCLUSION: The R.E.N.A.L. nephrometry score is a comprehensive assessment tool for delineating renal tumor anatomy. The reproducibility of R.E.N.A.L. nephrometry scores is substantial, but further research is required to evaluate its performance in predicting operative outcomes more accurately.

Dissolution/reorganization toward the destruction/construction of porous cobalt(II)- and nickel(II)-carboxylate coordination polymers.

The alkali-metal-cation-induced structural transformation of porous coordination polymers (CPs), {A(2)[M(3)(btec)(2)(H(2)O)(4)]}(n) (1, A = K, M = Co; 2, A = K, M = Ni; 3, A = Cs, M = Co; and 4, A = Cs, M = Ni; btec = benzene-1,2,4,5-tetracarboxylate), occurred via a unique dissolution/reorganization process in the presence of an alkali chloride (LiCl, NaCl) in water. Treatment of 1 or 2 in an aqueous solution of LiCl resulted in the formation of new metal-carboxylate species [Co(2)(btec)(H(2)O)(10)] x H(2)O (5 x H(2)O) and {Li(2)[Ni(3)(btec)(2)(H(2)O)(10)] x 3.5 H(2)O}(n) (6 x 3.5 H(2)O), respectively. When NaCl was used in place of LiCl under similar reaction conditions, similar dissolution/reorganization processes were observed. The cobalt species 1 and 3 were converted into the metal-carboxylate product [Na(2)Co(btec)(H(2)O)(8)](n) (7), whereas the nickel-carboxylate frameworks 2 and 4 were transformed into {[Na(4)Ni(2)(btec)(2)(H(2)O)(18)] x 3 H(2)O}(n) (8 x 3 H(2)O). Single-crystal X-ray diffraction analysis revealed that 5 x H(2)O is a discrete molecule, which extends to a hydrogen-bonded 3D porous supramolecular network including tetrameric water aggregates. Compound 6 x 3.5 H(2)O adopts a 3D polymeric structure with a novel (2,4,4)-connected net on the basis of a 4-connecting organic node of a btec ligand, a square-planar 4-connecting metallic trans-Ni(O(2)C)(4)(H(2)O)(2) node, and a 2-connecting octahedral metallic trans-Ni(O(2)C)(2)(H(2)O)(4) hinge. Compound 7 possesses a 3D polymeric structure comprised of two types of intercrossed (4,4)-layers, a [Co(II)(btec)]-based layer and a [Na(I)(btec)]-based layer, in a nearly perpendicular orientation (ca. 87 degrees). Compound 8 x 3 H(2)O adopted a 2D sheet network by utilizing heterometallic trinuclear clusters of Na(2)Ni(O(2)C)(5)(H(2)O)(9) as secondary building units. Each sheet is hydrogen-bonded to neighboring units, giving a 3D supramolecular network. It is noteworthy that the dissolution/reorganization process demonstrates the cleavage and reformation of metal-carboxylate bonds, leading to a destruction/construction structural transformation of CPs.