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1.
Cancer Biomark ; 13(5): 307-13, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24440969

RESUMO

BACKGROUND: Vascular endothelial growth factor (VEGF) affects tumor growth and metastasis by mediating angiogenesis. Vascular endothelial growth factor overexpression is considered a predictor of poor prognosis in cancer patients. Exercise may increase the circulating levels of VEGF, which is important to angiogenesis. We examined the effects of exercise training on VEGF levels and tumor growth in male C57BL/6 mice inoculated with Lewis lung cancer cells. METHODS: Thirty-two mice were randomly assigned to either the tumor control (TC, n=16) group or the tumor exercise (TE, n=16) group. Half of the mice in TE group received aerobic interval exercise training, and the other half received aerobic continuous exercise training for 4 weeks. The animal weights and tumor volumes were assessed three times per week. Serum VEGF levels were determined at baseline, 2 and 4 weeks. The solid tumor, lung and liver were excised and evaluated at study completion. RESULTS: There was a significant increase in VEGF levels after the 4-week exercise training program in TE group, but no significant changes were observed in TC group. CONCLUSIONS: Although exercise training increased serum VEGF levels, group differences were not evident in our study. Exercise training did not alter the survival rate or tumor growth in tumor-bearing mice.


Assuntos
Carcinoma Pulmonar de Lewis/sangue , Neoplasias Hepáticas Experimentais/sangue , Fator A de Crescimento do Endotélio Vascular/sangue , Animais , Carcinoma Pulmonar de Lewis/patologia , Linhagem Celular Tumoral , Neoplasias Hepáticas Experimentais/secundário , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Transplante de Neoplasias , Condicionamento Físico Animal , Carga Tumoral
2.
BMC Health Serv Res ; 12: 255, 2012 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-22898402

RESUMO

BACKGROUND: Cancer is a major cause of global morbidity and mortality. Since a high prevalence of functional impairments has been observed among cancer patients, rehabilitation has been proposed as a strategy to restore patients' functional independence. The increasing number of cancer patients combined with a growing need for rehabilitation may result in increased utilization of rehabilitation services. This study aimed to investigate the utilization of rehabilitation services among hospitalized cancer patients in Taiwan between 2004 and 2008. METHODS: Annual admissions and total inpatient expenditures for admissions with a cancer diagnosis were calculated from the National Health Insurance Research Database (NHIRD). Rehabilitation services used by cancer and non-cancer patients, as well as the distributions of rehabilitation service type among the different hospital departments were also analyzed. RESULTS: The percentages of inpatient admissions with a cancer diagnosis increased from 14.01% to 17.1% between 2004 and 2008. During 2004, 5.25% of all inpatient admissions received rehabilitation services; this percentage increased to 5.62% by 2008. Among cancer admissions, 2.26% to 2.62% received rehabilitation services from 2004 to 2008. By comparison, 5.68% to 6.24% of non-cancer admissions received rehabilitation services during this period. Of the admissions who received rehabilitation services, only 6.44% and 7.96% had a cancer diagnosis in 2004 and 2008, respectively. Sixty-one percent of rehabilitation services were delivered in the departments of orthopedics (25.6%), neurology (14.4%), rehabilitation (11.9%), and neurosurgery (9.2%). CONCLUSIONS: In Taiwan, the utilization of rehabilitation services during hospitalization increased from 2004 to 2008. Although this trend was noted for cancer and non-cancer admissions, the utilization of rehabilitation services was generally greater by non-cancer admissions. Despite the benefits of rehabilitation, the actual rehabilitation needs of cancer patients remain unmet.


Assuntos
Tempo de Internação/economia , Programas Nacionais de Saúde , Neoplasias/reabilitação , Serviço Hospitalar de Terapia Ocupacional/estatística & dados numéricos , Admissão do Paciente/estatística & dados numéricos , Serviço Hospitalar de Fisioterapia/estatística & dados numéricos , Gastos em Saúde , Humanos , Tempo de Internação/estatística & dados numéricos , Neoplasias/economia , Serviço Hospitalar de Terapia Ocupacional/economia , Admissão do Paciente/tendências , Serviço Hospitalar de Fisioterapia/economia , Estudos Retrospectivos , Índice de Gravidade de Doença , Taiwan/epidemiologia , Cobertura Universal do Seguro de Saúde
3.
Support Care Cancer ; 20(12): 3169-77, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22526147

RESUMO

PURPOSE: Peak oxygen consumption (VO(2peak)) is an important predictive factor for long-term prognosis in patients with non-small cell lung cancer (NSCLC). The purpose of this study was to investigate whether 8 weeks of exercise training improves exercise capacity, as assessed by VO(2peak), and other related factors in patients with NSCLC receiving targeted therapy. METHODS: A total of 24 participants with adenocarcinoma were randomly assigned to either the control group (n = 11) or the exercise group (n = 13). Subjects in the exercise group participated in individualized, high-intensity aerobic interval training of exercise. The outcome measures assessed at baseline and after 8 weeks were as follows: VO(2peak) and the percentage of predicted VO(2peak) (%predVO(2peak)), muscle strength and endurance of the right quadriceps, muscle oxygenation during exercise, insulin resistance as calculated by the homeostasis model, high-sensitivity C-reactive protein, and quality of life (QoL) questionnaire inventory. RESULTS: No exercise-related adverse events were reported. After exercise training, VO(2peak) and %predVO(2peak) increased by 1.6 mL kg(-1) min(-1) and 5.3% (p < 0.005), respectively; these changes were associated with improvements in circulatory, respiratory, and muscular functions at peak exercise (all p = 0.001). The exercise group also had less dyspnea (p = 0.01) and favorably lower fatigue (p = 0.05) than baseline. CONCLUSIONS: Patients with NSCLC receiving targeted therapy have quite a low exercise capacity, even with a relatively high QoL. Exercise training appears to improve exercise capacity and alleviate some cancer-related symptoms.


Assuntos
Adenocarcinoma/reabilitação , Terapia por Exercício/métodos , Tolerância ao Exercício , Neoplasias Pulmonares/reabilitação , Consumo de Oxigênio , Adenocarcinoma/complicações , Adulto , Idoso , Proteína C-Reativa , Dispneia/etiologia , Dispneia/reabilitação , Teste de Esforço , Fadiga/etiologia , Fadiga/reabilitação , Feminino , Humanos , Resistência à Insulina , Neoplasias Pulmonares/complicações , Masculino , Pessoa de Meia-Idade , Força Muscular , Resistência Física , Prognóstico , Músculo Quadríceps , Qualidade de Vida , Inquéritos e Questionários , Resultado do Tratamento
4.
J Vasc Surg ; 54(4): 1074-80, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21784604

RESUMO

OBJECTIVE: We investigated the usefulness of infrared thermography in evaluating patients at high risk for lower extremity peripheral arterial disease (PAD), including severity, functional capacity, and quality of life. METHODS: A total of 51 patients (23 males; age 70 ± 9.8 years) were recruited. They completed three PAD-associated questionnaires, including walking impairment, vascular quality of life, and 7-day physical activity recall questionnaires before a 6-minute walking test (6MWT). Ankle-brachial index (ABI) and segmental pressure were analyzed for PAD diagnosis and stenotic level assessment. The cutaneous temperature at shin and sole were recorded by infrared thermography before and after the walk test. Detailed demographic information and medication list were obtained. RESULTS: Twenty-eight subjects had abnormal ABI (ABI <1), while PAD was diagnosed in 20. No subjects had non-compressible artery (ABI >1.3). Demographic profiles and clinical parameters in PAD and non-PAD patients were similar, except for age, smoking history, and hyperlipidemia. PAD patients walked shorter distances (356 ± 102 m vs 218 ± 92 m; P < .001). Claudication occurred in 14 patients, while seven failed in completing the 6MWT. The rest temperatures were similar in PAD and non-PAD patients. However, the post-exercise temperature dropped in the lower extremities with arterial stenosis, but was maintained or elevated slightly in the extremities with patent arteries (temperature changes at sole in PAD vs non-PAD patients: -1.25 vs -0.15°C; P < .001). The exercise-induced temperature changes at the sole were not only positively correlated with the 6MWD (Spearman correlation coefficient = 0.31, P = .03), but was also correlated with ABI (Spearman correlation coefficient = 0.48, P < .001) and 7-day physical activity recall scores (Spearman correlation coefficient = 0.30, P = .033). CONCLUSION: By detecting cutaneous temperature changes in the lower extremities, infrared thermography offers another non-invasive, contrast-free option in PAD evaluation and functional assessment.


Assuntos
Raios Infravermelhos , Extremidade Inferior/irrigação sanguínea , Doença Arterial Periférica/diagnóstico , Temperatura Cutânea , Termografia/métodos , Idoso , Índice Tornozelo-Braço , Teste de Esforço , Tolerância ao Exercício , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doença Arterial Periférica/fisiopatologia , Doença Arterial Periférica/psicologia , Valor Preditivo dos Testes , Qualidade de Vida , Fluxo Sanguíneo Regional , Índice de Gravidade de Doença , Inquéritos e Questionários , Taiwan , Vasodilatação , Caminhada
5.
Oncol Lett ; 2(6): 1143-1147, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22848279

RESUMO

Vascular endothelial growth factor-A (VEGF-A) affects tumor growth and metastasis through stimulation of angiogenesis. The purpose of this study was to describe features of Lewis lung cancer (LLC) in mice and compare the serum VEGF-A levels with those of normal control mice. Two groups of mice were compared: one was subcutaneously injected with LLC cells (n=16) and the other served as the normal control (n=6). The serum VEGF-A levels were measured by ELISA prior to inoculation, and at 7, 21 and 35 days post-inoculation. The tumor weight and the metastatic condition were evaluated on day 35. Changes in body weight and serum VEGF-A concentration over a period of time were compared between the groups using generalized estimating equations. The relationship between the primary tumor and the metastatic condition was analyzed using the Spearman's rank correlation test. The survival rate was 56.3% on day 35 post-tumor inoculation. No difference was found between the groups with regard to gastrocnemius muscle weight on day 35 post-inoculation [0.1315±0.0066 g vs. 0.1308±0.0069 g (normal control)]. In tumor-bearing mice, the weight gain at sacrifice was less (0.24±0.45 vs. 1.93±0.47 g, P=0.01), the final mean tumor volume and weight were 4264.69±1038.32 mm(3) and 3.70±0.83 g, the number of nodules in the lungs and livers was 6.33 (range 0-20) and 2.22 (range 0-11), respectively, and the serum VEGF-A levels were significantly higher than those of control mice. In conclusion, lower body weight gain, metastasis in the liver and lungs, and elevated VEGF-A levels are features of LLC in mice.

6.
Cardiology ; 110(3): 191-8, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18057890

RESUMO

OBJECTIVES: The aims of this study were to clarify the influence of cardiac diastolic and peripheral vascular function on the exercise capacity of patients with coronary bypass surgery (CABG) and diabetes mellitus (DM) by tissue Doppler imaging (TDI) and flow-mediated vasodilatation (FMD), and to investigate interrelations between exercise capacity and LV diastolic function, endothelial function and biochemical parameters. METHODS: We analyzed the exercise capacity, TDI at the mitral annulus and FMD in 51 uncomplicated first-time CABG survivors (23 DM) at an average interval of 21.6 +/- 12.2 months after surgery. RESULTS: Diabetics had lower E', A', VO(2)peak, (a-v)O(2) difference, and higher E/E' ratios (p < 0.05) than non-DM patients, but not FMD (p = 0.17). The A and E/E' ratios correlated negatively with VO(2)peak after age adjustment (r = -0.336, p = 0.024). In addition, HbA(1c), and triglyceride also correlated negatively with VO(2)peak (r = -0.377, -0.307, respectively, p < 0.05). CONCLUSIONS: Diabetics after CABG had more advanced diastolic dysfunction and oxygen extraction impairment than non-DM. It suggests these factors could contribute to lower exercise capacity, risk of developing heart failure despite preserved systolic function and poorer long-term survival of diabetic patients after CABG.


Assuntos
Ponte de Artéria Coronária , Doença das Coronárias/fisiopatologia , Complicações do Diabetes , Endotélio Vascular/fisiopatologia , Tolerância ao Exercício , Contração Miocárdica , Função Ventricular Esquerda , Adulto , Idoso , Velocidade do Fluxo Sanguíneo , Artéria Braquial , Doença das Coronárias/complicações , Doença das Coronárias/cirurgia , Diástole , Ecocardiografia Doppler , Teste de Esforço , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Vasodilatação
7.
J Formos Med Assoc ; 101(1): 60-7, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11911040

RESUMO

BACKGROUND AND PURPOSE: Cardiac rehabilitation (CR) programs can effectively increase exercise capacity after an acute myocardial infarction (AMI). The purpose of this study was to investigate the changes in exercise capacity at the end of a supervised CR program and to determine the factors influencing exercise capacity 6 months after the end of a supervised CR program. METHODS: One hundred and four AMI patients who completed an 8-week supervised CR program were included in the study. Those who had an increased exercise capacity at the end of the 8-week supervised CR program were followed for 6 months to determine the possible factors influencing exercise capacity. Student's-t, chi-square, and ANOVA tests were used to make comparisons between groups and among stages of the program. RESULTS: All participants had a significant increase in exercise capacity and high-density lipoprotein cholesterol (HDL-C) at the end of the 8-week supervised CR program. The anaerobic threshold increased from 0.94 +/- 0.19 to 1.11 +/- 0.19 W/kg (p < 0.05) and serum HDL-C increased from 36.0 +/- 8.7 to 41.1 +/- 10.7 mg/dL (p < 0.05). Follow-up results demonstrated that smoking cessation, decrease in body mass index, and participation in leisure time physical activities were positively associated with increased exercise capacity. CONCLUSION: This study demonstrated that a supervised CR program improves exercise capacity and serum lipid profile in patients after AMI. Status of smoking, body mass index, and leisure time physical activities affect the long-term results of exercise training.


Assuntos
Terapia por Exercício , Infarto do Miocárdio/reabilitação , Teste de Esforço , Humanos , Lipídeos/sangue , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/sangue , Infarto do Miocárdio/fisiopatologia , Consumo de Oxigênio , Resistência Física
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