1.
J Nat Prod
; 83(9): 2797-2802, 2020 09 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32880456
RESUMO
Four new tetrahydroanthracene derivatives (1, 3-5) and a known antibiotic, A-39183A (2), were discovered from the marine-sponge-derived actinomycete Streptomyces fumigatiscleroticus HDN10255. Their structures including absolute configurations were elucidated based upon MS and NMR spectroscopic data, ECD calculations, and biogenetic considerations. Compounds 2 and 4 showed considerable cytotoxicity with the best IC50 value of 1.8 µM against HeLa cells.