Assuntos
Doenças do Desenvolvimento Ósseo/etiologia , Cartilagem/anormalidades , Cartilagem/diagnóstico por imagem , Imageamento Tridimensional , Anormalidades Musculoesqueléticas/etiologia , Costelas/anormalidades , Costelas/diagnóstico por imagem , Esterno/anormalidades , Esterno/diagnóstico por imagem , Tomografia Computadorizada por Raios X , HumanosAssuntos
Endoscopia , Tórax em Funil/cirurgia , Procedimentos Ortopédicos/métodos , Feminino , Humanos , MasculinoAssuntos
Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/cirurgia , Invasividade Neoplásica/patologia , Cirurgia Torácica Vídeoassistida/métodos , Broncoscopia/métodos , Citodiagnóstico/métodos , Humanos , Estadiamento de Neoplasias , Artéria Pulmonar/patologia , Veias Pulmonares/patologia , Sensibilidade e Especificidade , Toracoscopia/métodosRESUMO
BACKGROUND: Management of neonates with congenital diaphragmatic hernia (CDH) has undergone many changes associated with increased survival of high-risk CDH. However, little is known about the long-term outcome of CDH infants. METHODS: Follow-up was performed in 85 newborn infants with CDH admitted in our neonatal intensive care unit between January 1991 and December 1998. Early (< 2 months) and late mortality (> or = 2 months), and respiratory, nutritional, musculoskeletal, and neurosensory outcome at 2 years were recorded. RESULTS: Surgical repair was performed in 59 infants (69%) at a median postnatal age of 124 (range, 38 to 246) hours. Extracorporeal membrane oxygenation was used in 26 (30%) newborn infants. Survival at 2 years was 51 of 85 (60%) (early death, 28/85 [33%]; late death, 6/85 [7%]). Late deaths occurred because of persistent pulmonary hypertension or iatrogenic complications. Twelve of 51 (24%) newborn infants were oxygen dependant at the postnatal age of 28 days, and 1 of 51 (1.9%) was still oxygen dependant at 2 years. Growth failure was noted in 9 of 51 (18%), mainly related to severe gastroesophageal reflux and oral aversion. Scoliosis was diagnosed in 2 infants. Neurologic examination at 2 years was normal in 45 of 51 (88%). Cerebral palsy and developmental delay were observed in 2 and 4 infants, respectively. Four infants (8%) experienced associated problems. Respiratory, nutritional, and musculoskeletal morbidity was higher in infants treated by extracorporeal membrane oxygenation (p < 0.05). CONCLUSIONS: CDH infants are at risk for adverse nutritional and respiratory outcome. Despite severe respiratory failure at birth, prolonged oxygen therapy above 2 years of age is uncommon. Conversely, failure to thrive related at least in part to gastroesophageal reflux and oral dysfunction remains the major problem at 2 years of age. However, both nutritional and respiratory problems tend to improve with age.
Assuntos
Hérnias Diafragmáticas Congênitas , Paralisia Cerebral/etiologia , Pré-Escolar , Deficiências do Desenvolvimento/etiologia , Oxigenação por Membrana Extracorpórea/efeitos adversos , Seguimentos , Transtornos do Crescimento/etiologia , Hérnia Diafragmática/complicações , Hérnia Diafragmática/mortalidade , Hérnia Diafragmática/cirurgia , Humanos , Lactente , Recém-Nascido , Escoliose/etiologiaRESUMO
We report the case of an infant born prematurely at 27 weeks gestational age with life-threatening pulmonary hypertension crisis as a result of left upper pulmonary vein stenosis. Surgical treatment consisted of a lobectomy, which is a safe and effective procedure. Evidence strongly suggests that the venous stenosis may have resulted from hypertonic drugs infused through an umbilical catheter facing the upper left venous-atrial junction.
Assuntos
Hipertensão Pulmonar/etiologia , Pneumopatia Veno-Oclusiva/etiologia , Feminino , Humanos , Lactente , Recém-Nascido , Doenças do Prematuro , Pneumopatia Veno-Oclusiva/complicaçõesRESUMO
BACKGROUND: The management of non-small cell carcinomas of the lung involving the superior sulcus remains controversial. The goal of this retrospective study was to evaluate the role of surgery, radiotherapy, and chemotherapy for the treatment of superior sulcus tumors, to define the best surgical approach for radical resection, and to identify factors influencing long-term survival. METHODS: Between 1983 and 1999, 139 patients underwent surgical resection of superior sulcus tumors in seven thoracic surgery centers. According to the classification of the American Joint Committee, 51.1% of cancers were stage IIB, 13.7% stage IIIA, 32.4% stage IIIB, and 2.9% stage IV. RESULTS: The resections were performed with 74.1% using the posterior approach and 25.9% using an anterior approach. A lobectomy was accomplished in 69.8% of the cases and a wedge resection in 22.3%. Resection of a segment of vertebrae or subclavian artery was performed, respectively, in 19.4% and 18% of the cases. Resection was complete in 81.3% of cancers. The overall 5-year survival rate was 35%. Preoperative radiotherapy improved 5-year survival for stages IIB-IIIA. Surgical approach, postoperative radiotherapy, or chemotherapy did not change survival. CONCLUSIONS: The optimal treatment for superior sulcus tumors is complete surgical resection. The surgical approach (anterior/posterior) did not influence the 5-year survival rate. Preoperative radiotherapy should be recommended to improve outcome of patients with a superior sulcus tumor.