1.
Nat Prod Res
; 32(22): 2670-2675, 2018 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28931326
RESUMO
Two new guaiane-type sesquiterpenes, kwangsiensis A and B (1-2) were isolated from the roots of Curcuma kwangsiensis. Their structures were elucidated by extensive spectroscopic methods, including NMR, circular dichroism (CD) and high-resolution mass-spectrometry. The anti-inflammatory activity of the two compounds was evaluated on the basis of their inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse RAW 264.7 macrophages. Compounds 1 and 2 showed moderate inhibitory activities with IC50 values of 27.4 and 35.1 µM, respectively.
Assuntos
Curcuma/química , Macrófagos/efeitos dos fármacos , Sesquiterpenos de Guaiano/farmacologia , Animais , China , Lipopolissacarídeos , Camundongos , Estrutura Molecular , Óxido Nítrico/biossíntese , Compostos Fitoquímicos/isolamento & purificação , Compostos Fitoquímicos/farmacologia , Raízes de Plantas/química , Células RAW 264.7 , Sesquiterpenos de Guaiano/isolamento & purificação
2.
Magn Reson Chem
; 55(2): 157-160, 2017 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27561092