1.
Yao Xue Xue Bao
; 51(8): 1285-9, 2016 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29906019
RESUMO
A new sesquiterpene, bakkenolide-â ¥a (1), was isolated from the rhizome of Petasites japonicas (Sieb. et Zucc.) Maxim. The structure was characterized on the basis of various NMR ((1)H, (13)C, (1)H-(1)H COSY, HMQC, HMBC and NOESY) and mass spectrometry data. Bakkenolide-â ¥a showed potent cerebral hypoxia- ischemia protective activity in mice subjected to decapitation through prolonging the survival time and gasping time. It also exhibited a protective activity against hypoxia injury in PC12 cells in anaerobic culture by inhibition of lactate dehydrogenase (LDH) release.