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2.
Arch Pharm Res ; 30(7): 816-9, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17703731

RESUMO

Two isocoumarin derivatives, stoloniferol A (1) and B (2), a known 5alpha, 8alpha-epidioxy-23-methyl-(22E, 24R)-ergosta-6, 22-dien-3beta-ol (3), and a known dihydrocitrinone (4) were isolated from the ethyl acetate extract of the sea squirt-derived fungus, Penicillium stoloniferum QY2-10, and a halophilic fungus, Penicillium notatum B-52, respectively. Their structures were elucidated by spectroscopic methods and optical rotation. The stereochemistry of 2 was determined on the basis of different NOE experiments and chemical transformation. Compound 3 showed cytotoxicity against P388 cells, with an IC50 value of 4.07 microM.


Assuntos
Antineoplásicos/isolamento & purificação , Isocumarinas/isolamento & purificação , Penicillium chrysogenum/química , Urocordados/microbiologia , Animais , Antineoplásicos/química , Antineoplásicos/farmacologia , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Cromatografia Líquida de Alta Pressão , Humanos , Concentração Inibidora 50 , Isocumarinas/química , Isocumarinas/farmacologia , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Penicillium/química , Penicillium/isolamento & purificação , Penicillium chrysogenum/isolamento & purificação , Água do Mar
3.
J Nat Prod ; 70(5): 853-5, 2007 May.
Artigo em Inglês | MEDLINE | ID: mdl-17455978

RESUMO

Three new quinazoline alkaloids, aurantiomides A (1), B (2), and C (3), along with the known metabolite anacine (4) were isolated from the sponge-derived fungus strain Penicillium aurantiogriseum SP0-19 by bioassay-guided fractionation. Their structures were elucidated by spectroscopic and chemical methods. Their absolute configurations were deduced by comparison of their Cotton effects with anacine (4) and by chemical transformations. Compounds 2 and 3 showed moderate cytotoxicities against HL-60, P388 and BEL-7402, P388 cell lines, respectively.


Assuntos
Alcaloides/isolamento & purificação , Penicillium/química , Quinazolinas/isolamento & purificação , Alcaloides/química , Animais , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Leucemia P388 , Camundongos , Estrutura Molecular , Poríferos/microbiologia , Quinazolinas/química
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