RESUMO
Due to the outbreak of coronavirus disease 2019 (COVID-19), the Chinese government implemented strict lockdown measures to control the spread of infection. The impact of the COVID-19 lockdown on eating habits and lifestyles in the general population is unclear. This cross-sectional study was conducted via an online survey to obtain an overview of the food access, food intake, and physical activity of Chinese residents during the initial stage of the COVID-19 lockdown, and to investigate the association between staying at home/working from home and changes in eating habits and lifestyles. A total of 2702 participants (70.7% women) were included. Most of the participants maintained their habitual diet, while 38.2% increased their snack intake, 54.3% reported reduced physical activity, and 45.5% had increased sleep duration. Most people (70.1%) reported no change in body weight, while 25.0% reported an increase. Always staying at home/working from home was associated with an increase in animal product, vegetable, fruit, mushroom, nut, water, and snack intake, as well as sleep duration and frequency of skipping breakfast (odds ratio (OR) 1.54, 1.62, 1.58, 1.53, 1.57, 1.52, 1.77, 2.29, and 1.76 respectively). Suggestions should be made to encourage people to reduce their snack intake, maintain the daily consumption of breakfast, and increase physical activity during future lockdown periods.
Assuntos
COVID-19/psicologia , Controle de Doenças Transmissíveis , Comportamento Alimentar , Estilo de Vida , Adolescente , Adulto , COVID-19/epidemiologia , China/epidemiologia , Controle de Doenças Transmissíveis/métodos , Controle de Doenças Transmissíveis/estatística & dados numéricos , Estudos Transversais , Dieta/psicologia , Dieta/estatística & dados numéricos , Ingestão de Alimentos/psicologia , Exercício Físico , Comportamento Alimentar/psicologia , Feminino , Abastecimento de Alimentos , Humanos , Masculino , Pessoa de Meia-Idade , Adulto JovemAssuntos
Angiomioma/patologia , Fossa Craniana Média , Neoplasias da Base do Crânio/patologia , Actinas/metabolismo , Angiomioma/metabolismo , Angiomioma/cirurgia , Diagnóstico Diferencial , Seguimentos , Humanos , Imageamento por Ressonância Magnética , Masculino , Antígenos Específicos de Melanoma/metabolismo , Pessoa de Meia-Idade , Neoplasias de Células Epitelioides Perivasculares/imunologia , Proteínas S100/metabolismo , Neoplasias da Base do Crânio/metabolismo , Neoplasias da Base do Crânio/cirurgia , Antígeno gp100 de MelanomaRESUMO
BACKGROUND: TRIM29 belongs to the tripartite motif (TRIM) protein family. It has been reported to be up-regulated or be down-regulated in many cancer types, suggesting the oncogenic function of TRIM29 may be depend on different molecular signaling pathway. It was found that ß-catenin function (a key molecule in the Wnt signaling pathway) was required for TRIM29's oncogenic effects. TRIM29 gene expression was also found to be heterogeneous in non-small-cell lung cancer (NSCLC) subtypes. In this study, the possible associations of TRIM29 expression with clinicopathological factors, prognosis, and ß-catenin in human NSCLC were analyzed. METHODS: TRIM29 and ß-catenin expression of tumor and adjacent normal tissues in 251 cases of NSCLC treated by surgery was detected by the Immunohistochemical method. The relationship between clinical pathological data, ß-catenin, and TRIM29 expression was analyzed. RESULTS: TRIM29 expression of tumor tissues was significantly higher than adjacent normal tissues. Expression of TRIM29 in squamous cell carcinoma (SC) tissues was positively correlated with abnormal expression of ß-catenin, histological grade, tumor-node-metastasis (TNM) stage, and lymph node metastasis and that was positively correlated with tumor size, histological grading, TNM stage and lymph node metastasis in adenocarcinoma (AC). TRIM29 expression in SC and AC was significantly different and the intensity of poorly differentiated SC was significantly higher than that of AC. High-expression of TRIM29, poorly differentiated grade, and high clinical stage were independent prognostic indicators. CONCLUSION: We considered that TRIM29 may play a reference role in distinguish poorly differentiated AC and SC of NSCLC, combining with CK5/6 and CK7, and it could improve postoperative assessment and have the reference value for clinical treatment. The interaction between TRIM29 and ß-catenin may participate in the development of lung SC.
Assuntos
Carcinoma Pulmonar de Células não Pequenas/patologia , Proteínas de Ligação a DNA/fisiologia , Neoplasias Pulmonares/patologia , Fatores de Transcrição/fisiologia , beta Catenina/fisiologia , Adenocarcinoma/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma Pulmonar de Células não Pequenas/etiologia , Carcinoma Pulmonar de Células não Pequenas/mortalidade , Carcinoma de Células Pequenas/etiologia , Carcinoma de Células Pequenas/patologia , Proteínas de Ligação a DNA/genética , Feminino , Humanos , Neoplasias Pulmonares/etiologia , Neoplasias Pulmonares/mortalidade , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Fatores de Transcrição/genética , beta Catenina/genéticaAssuntos
Astrocitoma/patologia , Neoplasias Encefálicas/patologia , Astrocitoma/metabolismo , Astrocitoma/cirurgia , Neoplasias Encefálicas/metabolismo , Neoplasias Encefálicas/cirurgia , Pré-Escolar , Diagnóstico Diferencial , Ependimoma/metabolismo , Ependimoma/patologia , Feminino , Seguimentos , Proteína Glial Fibrilar Ácida/metabolismo , Humanos , Recidiva Local de Neoplasia , Estadiamento de Neoplasias , Neurofibroma Plexiforme/metabolismo , Neurofibroma Plexiforme/patologia , Proteínas S100/metabolismo , Vimentina/metabolismoAssuntos
Neoplasias do Sistema Nervoso Central/patologia , Microvasos/patologia , Astrocitoma/irrigação sanguínea , Astrocitoma/patologia , Capilares/patologia , Neoplasias do Sistema Nervoso Central/irrigação sanguínea , Diagnóstico Diferencial , Ependimoma/irrigação sanguínea , Ependimoma/patologia , Glioblastoma/irrigação sanguínea , Glioblastoma/patologia , Hemangioblastoma/irrigação sanguínea , Hemangioblastoma/patologia , Humanos , Hiperplasia , Neoplasias Neuroepiteliomatosas/irrigação sanguínea , Neoplasias Neuroepiteliomatosas/patologia , Oligodendroglioma/irrigação sanguínea , Oligodendroglioma/patologia , Paraganglioma/irrigação sanguínea , Paraganglioma/patologiaAssuntos
Carcinoma Pulmonar de Células não Pequenas/patologia , Proteínas de Ligação a DNA/metabolismo , Neoplasias Pulmonares/patologia , Fatores de Transcrição/metabolismo , beta Catenina/metabolismo , Adenocarcinoma/metabolismo , Adenocarcinoma/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma Pulmonar de Células não Pequenas/metabolismo , Carcinoma de Células Escamosas/metabolismo , Carcinoma de Células Escamosas/patologia , Feminino , Humanos , Neoplasias Pulmonares/metabolismo , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Carga TumoralAssuntos
Artéria Pulmonar , Sarcoma/patologia , Neoplasias Vasculares/patologia , Actinas/metabolismo , Antígenos CD/metabolismo , Antígenos de Diferenciação Mielomonocítica/metabolismo , Diagnóstico Diferencial , Feminino , Humanos , Neoplasias Renais/patologia , Pessoa de Meia-Idade , Embolia Pulmonar/patologia , Radiografia , Sarcoma/diagnóstico por imagem , Sarcoma/metabolismo , Sarcoma/cirurgia , Neoplasias Vasculares/diagnóstico por imagem , Neoplasias Vasculares/metabolismo , Neoplasias Vasculares/cirurgia , Vimentina/metabolismoRESUMO
Here, the authors describe a case of giant-cell anaplastic carcinoma with osteoclastic giant cells of the chest cavity-which could be a distinctive form of thymic carcinoma-which expressed CD5 and CD45. To the authors' knowledge, there has been no previous report on this subject. A 62-year-old woman presented with continuous pain in the left back associated with coughing and shortness of breath for more than 2 months prior to referral to the hospital. Palliative resection of a mediastinal tumor was performed. During the operation, it was found that the mass occupied most of the chest invading the chest wall, aorta, vena cava, and lung tissue. The patient soon died from diabetic complications in spite of anti-infection treatment. The tumor was composed of large areas of necrosis and anaplastic neoplastic giant cells with high mitotic activity, and osteoclast-like cells; there was marked inflammatory cell infiltration. The anaplastic neoplastic giant cells were immunoreactive for CKpan, CD5, CD45, VIM, and p53. Approximately 50% to 60% of the tumor cells showed immunoreactivity for Ki-67. In situ hybridization for Epstein-Barr virus-encoded RNA was negative for tumor cells and nonneoplastic osteoclastic giant cells. Because this tumor is very rare, extensive clinical, radiological, and morphological examinations as well as immunohistochemical studies are essential to make the diagnosis.