1.
Chem Commun (Camb)
; 58(77): 10797-10800, 2022 Sep 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36069382
RESUMO
A photo-activated aptamer-drug conjugate, HG1-9-DNP, was developed based on an aptamer HG1-9 and a photolabile naphthalimide derivative DNP. HG1-9-DNP could be internalized into cells mediated by TfR, then photocleaved, and released a promising cytotoxic agent, DNNH, which arrested the cell cycle at the G2/M phase, resulting in high photo-induced cytotoxicity.
Assuntos
Aptâmeros de Nucleotídeos , Doxorrubicina , Aptâmeros de Nucleotídeos/metabolismo , Aptâmeros de Nucleotídeos/farmacologia , Linhagem Celular Tumoral , Citotoxinas , Doxorrubicina/farmacologia , Sistemas de Liberação de Medicamentos/métodos , Naftalimidas , Oligonucleotídeos , Preparações Farmacêuticas
2.
A 4-aminonaphthalimide-based fluorescent traceable prodrug with excellent photoinduced cytotoxicity.
Chem Commun (Camb)
; 57(53): 6558-6561, 2021 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34113937
RESUMO
A blue light activated anti-cancer prodrug, NST, was designed based on a photoactive 4-aminonaphthalimide derivative and an anticancer drug, 10-hydroxycamptothecin. NST was hard to be taken up by living cells and showed negligible dark cytotoxicity. The irradiation caused photocleavage of NST and resulted in high cytotoxicity.