In-situ formation of niobium oxide - Niobium carbide - Reduced graphene oxide ternary nanocomposite as an electrochemical sensor for sensitive detection of anticancer drug methotrexate.

Engineering the nanostructure of an electrocatalyst is crucial in developing a high-performance electrochemical sensor. This work exhibits the hydrothermal followed by annealing synthesis of niobium oxide/niobium carbide/reduced graphene oxide (NbO/NbC/rGO) ternary nanocomposite. The oval-shaped NbO/NbC nanoparticles cover the surface of rGO evenly, and the rGO nanosheets are interlinked to produce a micro-flower-like architecture. The NbO/NbC/rGO nanocomposite-modified electrode is presented here for the first time for the rapid and sensitive electrochemical detection of the anticancer drug methotrexate (MTX). Down-sized NbO/NbC nanoparticles and rGO's high surface area provide many active sites with a rapid electron transfer rate, making them ideal for MTX detection. In comparison to previously reported MTX sensors, the developed drug sensor exhibits a lower oxidation potential and a higher peak current responsiveness. The constructed sensors worked analytically well under optimal conditions, as shown by a low detection limit of 1.6 nM, a broad linear range of 0.1-850 µM, and significant recovery findings (∼98 %, (n = 3)) in real samples analysis. Thus, NbO/NbC/rGO nanocomposite material for high-performance electrochemical applications seems promising.

Hierarchical 3D Snowflake-like Iron Diselenide: A Robust Electrocatalyst for Furaltadone Detection.

An electrocatalyst with a large active site is critical for the development of a high-performance electrochemical sensor. This work demonstrates the fabrication of an iron diselenide (FeSe2)-modified screen-printed carbon electrode (SPCE) for the electrochemical determination of furaltadone (FLD). It has been prepared by the facile method and systematically characterized with various microscopic/spectroscopic approaches. Due to advantageous physiochemical properties, the FeSe2/SPCE showed a low charge-transfer resistance value of 200 Ω in 5.0 mM [Fe(CN)6]3-/4- containing 0.1 M KCl. More importantly, the FeSe2/SPCE exhibited superior catalytic performance compared to the bare SPCE for FLD sensing based on the electrochemical response in terms of a peak potential of -0.44 V (vs Ag/AgCl (sat. KCl)) and cathodic response current of -22.8 µA. Operating at optimal conditions, the FeSe2-modified electrode showed wide linearity from 0.01 to 252.2 µM with a limit of detection of 0.002 µM and sensitivity of 1.15 µA µM-1 cm-2. The analytical performance of the FeSe2-based platform is significantly higher than many previously reported FLD electrochemical sensors. Furthermore, the FeSe2/SPCE also has a promising platform for FLD detection with high sensitivity, good selectivity, excellent stability, and robust reproducibility. Thus, the finding above shows that the FeSe2/SPCE is a highly suitable candidate for the electrochemical determination of glucose levels for real-time applications such as in human urine and river water samples.

Enhancing catalytic activity through the construction of praseodymium tungstate decorated on hierarchical three-dimensional porous biocarbon for determination of furazolidone in aquatic samples.

Boosting catalytic performance as a vital role for an electrochemical sensor for monitoring various hazardous nitro drugs. Herein, an inexpensive, facile, and eco-friendly construction of praseodymium tungstate decorated on three dimensional porous biocarbon (PrW/3D-PBC) for electrochemical determination of carcinogenic residue furazolidone (FZ). The nanostructured PrW nanoparticles were prepared by solvent evaporation from peroxo-tungstic acid and 3D-PBC was prepared from biomass precursor under the carbonization method. Furthermore, the composite of PrW decorated on 3D-PBC was prepared by an ultrasonic-assisted wet chemical approach. Besides, the composite characterization of crystalline, functional group, degree of carbonization, chemical states, and morphology were utilized by theXRD, FTIR, RAMAN, XPS, and FESEM analysis. These 3D porous carbon decorated PrW nanoparticles facilitate the electrochemical anchoring sites, surface area, and ease of diffusion layers towards the detection of hazardous nitro pollutant FZ by using CV analysis. The low LOD and high sensitivity were achieved by FZ determination through using LSV and DPV techniques. The practical capability of the PrW/3D-PBC/GCE sensor was determined by using aquatic samples to achieve a good recovery result. These results instigate that the PrW/3D-PBC will be an efficient electrocatalytic material for FZ sensor in environmental aquatic samples.