1.
J Org Chem
; 87(24): 16399-16409, 2022 12 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36473230
RESUMO
A series of 2,4-di-arylated tropane derivatives was synthesized through a site-selective palladium-catalyzed ß-C(sp3)-H di-arylation process. This type of structure has been scarcely reported in literature. They nevertheless represent an interesting class of biologically relevant molecules as illustrated by the observed activity at the micromolecular level of eight derivatives toward human colorectal cancer cell line HCT116.