Assuntos
Doença de Alzheimer/metabolismo , Peptídeos beta-Amiloides/metabolismo , Fragmentos de Peptídeos/metabolismo , ATPases Vacuolares Próton-Translocadoras/metabolismo , Adenosina Trifosfatases/fisiologia , Doença de Alzheimer/genética , Doença de Alzheimer/patologia , Peptídeos beta-Amiloides/genética , Animais , Humanos , Camundongos , Camundongos Transgênicos , Fragmentos de Peptídeos/genética , ATPases Vacuolares Próton-Translocadoras/genéticaRESUMO
OBJECTIVE: To study the relationship between cystatin C and cerebral infarction and explore the role of cystatin C in the protection against cerebral infarction. METHOD: Eighty-three patients with cerebral infarction and 71 randomly selected age- and gender-matched patients in the Department of Neurology (control group) were enrolled in this study. Fasting whole blood (3 ml) was obtained from the patients in both groups and the sera were separated to determine the levels of cystatin C using particle reinforced immunoturbidimetric assay. RESULTS: The serum cystatin C level was significantly lower in the cerebral infarction group than in the control group (1.62-/+0.31 vs 2.23-/+0.22 mg/L, P<0.01). CONCLUSIONS: Cystatin C is closely related to cerebral infarction probably as a protective factor against cerebral infarction.