Transoesophageal echocardiography for prediction of postoperative atrial fibrillation after isolated aortic valve replacement: two-dimensional speckle tracking for intraoperative assessment of left ventricular longitudinal strain.

OBJECTIVES: Recent studies suggested association between impaired left ventricular long-axis function and arrhythmic events early after open heart surgery. This prospective study investigated the predictive value of a depressed intraoperative global longitudinal strain (GLS) for postoperative atrial fibrillation after isolated aortic valve replacement in patients with preserved ejection fraction. METHODS: A total of 107 patients with ejection fraction ≥50% and moderate-to-severe aortic stenosis undergoing isolated aortic valve replacement were enrolled. All patients underwent intraoperative transoesophageal echocardiography before surgical incision (T1) and after closure of the sternotomy (T2) with semiautomated measurement of GLS, and were followed for the occurrence of postoperative atrial fibrillation during the hospitalization. RESULTS: The incidence of postoperative atrial fibrillation was 37/107 (34.6%). Patients with postoperative atrial fibrillation were associated with increased length of hospitalization and a higher risk of low cardiac output syndrome and pulmonary complications. On univariate analysis, significant risk factors associated with postoperative atrial fibrillation were E/e' ratio, left atrial volume index (LAVi), GLST2 and ΔGLS%. On multivariable analysis, GLST2 (odds ratio: 1.21; 95% confidence interval (CI): 1.06-1.56, P = 0.031) and ΔGLS% (odds ratio: 3.66; 95% CI: 1.85-6.79, P = 0.001) were independent predictors of postoperative atrial fibrillation. The best cut-off values for the prediction were GLST2 >-12.75% and ΔGLS% >19.50%, the latter of which had incremental predictive value for postoperative atrial fibrillation. CONCLUSIONS: A significant reduction of intraoperative GLS provides independent information for predicting postoperative atrial fibrillation in patients undergoing aortic valve replacement, and may help to identify patients who are most likely to benefit from targeted prophylaxis.

Seventeen-millimeter St. Jude Medical Regent valve in patients with small aortic annulus: dose moderate prosthesis-patient mismatch matter?

BACKGROUND: The study was designed to evaluate the effects of moderate prosthesis-patient mismatch (defined as 0.65 cm(2)/m(2)

Bone morphogenic protein-4: a potential novel target for preventing vein graft failure in coronary revascularization.

Coronary artery bypass surgery is an effective and durable therapy in both acute coronary syndrome and chronic coronary stenotic disease refractory to pharmacological treatment. Despite rapid development in operation-specific technologies and secondary prevention measures, the benefits of surgical revascularization are largely limited by inadequate patency of one of the most commonly used conduits, namely the autologous saphenous vein. However, apart from antiplatelet and lipid-lowering drugs, no other pharmacologic agent has hitherto proven clinically effective in preventing short- and long-term vein graft failure. Aiming at a large number of known biomolecules, multiple promising strategies failed to translate their beneficial effects observed in animal models into the clinical settings. Bone morphogenic protein-4 (BMP4), originally identified as a mediator in bone formation, has been recently demonstrated to participate in the process of arterial post-injury remodeling. Existing evidence has demonstrated that BMP4 is closely involved in the pathogenesis of thrombus formation, neointimal hyperplasia and superimposed atherosclerosis, all of which significantly contribute to arterial stenotic lesions. Although the post-injury responses inherent to arterial and venous vessel are unique, they share common elements and present with similar physiologic characteristics and clinical sequelae. Therefore, with regard to the multifaceted effects of BMP4 in regulating arterial wall remodeling, we hypothesize that BMP4 may play an important role in mediating the pathological responses of the venous wall to the arterial circulation. If our hypothesis is demonstrated correct, BMP4 inhibition could presumably serve as a novel strategy for preventing vein graft failure in coronary revascularization.