Neutrophil extracellular traps in central nervous system (CNS) diseases.

Excessive induction of inflammatory and immune responses is widely considered as one of vital factors contributing to the pathogenesis and progression of central nervous system (CNS) diseases. Neutrophils are well-studied members of inflammatory and immune cell family, contributing to the innate and adaptive immunity. Neutrophil-released neutrophil extracellular traps (NETs) play an important role in the regulation of various kinds of diseases, including CNS diseases. In this review, current knowledge on the biological features of NETs will be introduced. In addition, the role of NETs in several popular and well-studied CNS diseases including cerebral stroke, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), and neurological cancers will be described and discussed through the reviewing of previous related studies.

[The development and changes of pressure of putrefactive gas in cadaveric enterocelia in spring and its forensic application].

OBJECTIVE: To study the development and changes of pressure of putrefactive gas (PPG) in cadaveric enterocelia in spring, and to explore its application in estimation of postmortem interval (EPI). METHODS: 57 goats were divided into 2 groups according to means of death, on land or in water. Celiac PPG were observed timely and systematically. RESULTS: The development of PPG in cadaveric enterocelia, which can be divided into raising phase, peak phase, and declining phase was observed, and a model to estimate postmortern interval by changes of PPG was founded. CONCLUSION: Measuring PPG in cadaveric enterocelia could be used in forensic EPI.