RESUMO
Purpose: The purpose of this report is to describe a case of bilateral Candida chorioretinitis complicated with choroidal neovascularization (CNV) and effectively treated with combined intravitreal bevacizumab and amphotericin B.Results: An 83-year-old patient was diagnosed with Candida chorioretinitis in both eyes. Optical coherence tomography and fluorescein angiography revealed CNV. Treatment using combined intravitreal bevacizumab and amphotericin B was initiated followed by a 4-weekly regimen of bevacizumab, eventually resulting in the regression of the subretinal fluid and intraretinal edema.Conclusion: Our study supports the combined use of intravitreal bevacizumab and amphotericin B in the management of CNV in Candida chorioretinitis.
Assuntos
Anfotericina B/uso terapêutico , Inibidores da Angiogênese/uso terapêutico , Antifúngicos/uso terapêutico , Candidíase/tratamento farmacológico , Coriorretinite/tratamento farmacológico , Neovascularização de Coroide/tratamento farmacológico , Infecções Oculares Fúngicas/tratamento farmacológico , Idoso de 80 Anos ou mais , Bevacizumab/uso terapêutico , Candidíase/microbiologia , Coriorretinite/microbiologia , Neovascularização de Coroide/diagnóstico por imagem , Neovascularização de Coroide/patologia , Corantes/administração & dosagem , Quimioterapia Combinada , Infecções Oculares Fúngicas/microbiologia , Angiofluoresceinografia , Humanos , Verde de Indocianina/administração & dosagem , Injeções Intravítreas , Masculino , Líquido Sub-Retiniano , Tomografia de Coerência Óptica , Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores , Acuidade Visual/fisiologiaRESUMO
We present a case of tubulointerstitial nephritis and uveitis (TINU) with nodular anterior scleritis and large-vessel arteritis. A 67-year-old patient was admitted to the hospital with high fever, thoracic pain, and weakness. Bilateral anterior uveitis was seen at that time. Laboratory examination showed acute renal failure. A renal biopsy was performed and showed pathognomonic signs of tubulointerstitial nephritis (TIN). Six months later, she developed ocular inflammation suggestive of nodular scleritis. One year after hospital admission, she presented with large-vessel arteritis. We describe a case of TINU with co-occurrence of scleritis and large-vessel arteritis.